Northern California Cooperative Family Registry for Breast Cancer
北加州乳腺癌合作家庭登记处
基本信息
- 批准号:7925993
- 负责人:
- 金额:$ 50.18万
- 依托单位:
- 依托单位国家:美国
- 项目类别:
- 财政年份:2009
- 资助国家:美国
- 起止时间:2009-09-01 至 2011-08-31
- 项目状态:已结题
- 来源:
- 关键词:AccountingAddressAffectAfrican AmericanAreaAustraliaBRCA1 geneBRCA2 MutationBehavioralBlood specimenBreastCaliforniaCanadaCancer FamilyCell LineClassificationClinicClinicalClinical PathologyCollaborationsCollectionCommunity OutreachCooperative Family RegistryDNADataData CollectionData QualityDietary intakeDocumentationEnrollmentEnsureFamilyFamily Cancer HistoryFamily history ofFamily memberFemaleFundingFutureGenesGeneticGenomicsGoalsGrantHereditary Breast CarcinomaHispanic AmericansHispanicsIndividualInformaticsInstitutionInterdisciplinary StudyInternationalInvestigationLeadershipMalignant NeoplasmsMalignant neoplasm of ovaryMedical RecordsMedical ResearchMethodsMinorityMinority GroupsMissense MutationModelingMolecularNational Cancer InstituteNew York CityOntarioOther GeneticsParticipantPathologyPhiladelphiaPopulationPopulation-Based RegistryPreparationPreventiveProceduresProcessProtocols documentationPublicationsQuestionnairesRecruitment ActivityRegistriesRelative (related person)ResearchResearch InfrastructureResearch PersonnelResource DevelopmentResourcesRetrievalRisk FactorsSamplingSiteStructureTestingTherapeutic InterventionTimeTissue MicroarrayUpdateUtahWorkbreast cancer familybreast cancer family registrycancer riskcohortearly onsetexperiencefollow-upgene environment interactiongenetic epidemiologyinstrumentinterestmalemalignant breast neoplasmmutation carrierneoplasm registrypopulation basedprobandprognosticpsychosocialrepositoryresponsesurvivorshiptooltranslational studytumor
项目摘要
DESCRIPTION (provided by applicant): Since the establishment in 1995, the Breast Cancer Family Registry (Breast CFR), an international consortium of six collaborating sites, has enrolled over 13,000 families across a wide range of breast cancer risk. The Northern California Family Registry for Breast Cancer (NC-FRBC) has contributed significantly to the resource and collected high-quality data on family history, epidemiologic risk factors and dietary intake, as well as biospecimens for over 2,600 families, including 1,900 minority families, which account for 70 percent of all enrolled minority families. The NC-FRBC brings many strengths to the Breast CFR, such as experienced leadership and collaborative partners, population-based sampling, targeted recruitment of minorities, new analytic methods, and successful data utilization. The objectives of this 5-year renewal grant are to: 1) establish and maintain a hypothesis-driven research infrastructure to expedite and implement collaborative, multi-disciplinary and multi-institutional research in genetic epidemiology of breast cancer; 2) re-structure the current infrastructure into nine Core Platforms and maintain and further enhance the existing resources; and 3) recruit an additional 830 population-based minority families (470 Hispanics, 360 African Americans). Core activities associated with each Platform include: a) conduct a systematic follow-up of probands and relatives enrolled from 1995-2005, and continue annual follow-up of all probands enrolled from 1995-2009; b) expand data and biospecimen collection in families of special interest (i.e., multiple case early-onset and BRCA1 and SRC/42 mutation carriers); c) expand clinical and prognostic data collection on probands and affected relatives; d) expand tumor block collection to construct tissue microarrays, e) enhance existing biospecimen resources and establish a duplicate repository; f) expand BRCA1 and BRCA2 mutation testing; g) maintain and enhance local informatics capabilities; h) contribute to resources to facilitate behavioral and psychosocial research; and i) coordinate internal registry functions and collaborations with Breast CFR and external investigators. This enhanced and expanded resource will facilitate a broad spectrum of research, ranging from identification of genetic factors related to breast cancer risk and their interactions with environmental and other genetic modifiers, to translational studies addressing clinical, behavioral and preventive aspects of breast cancer.
描述(由申请人提供):自 1995 年成立以来,乳腺癌家族登记处 (Breast CFR) 作为一个由六个合作机构组成的国际联盟,已登记了 13,000 多个家庭,涵盖各种乳腺癌风险。北加州乳腺癌家庭登记处 (NC-FRBC) 对该资源做出了重大贡献,收集了有关家族史、流行病学危险因素和饮食摄入量的高质量数据,以及 2,600 多个家庭(其中包括 1,900 个少数族裔家庭)的生物样本,占全部入学少数民族家庭的70%。 NC-FRBC 为乳腺 CFR 带来了许多优势,例如经验丰富的领导和合作伙伴、基于人群的抽样、有针对性地招募少数群体、新的分析方法以及成功的数据利用。这项为期 5 年的续期赠款的目标是:1)建立和维护假设驱动的研究基础设施,以加快和实施乳腺癌遗传流行病学领域的协作、多学科和多机构研究; 2)将现有基础设施重组为九个核心平台,并维护并进一步增强现有资源; 3) 招募另外 830 个以人口为基础的少数族裔家庭(470 个西班牙裔,360 个非裔美国人)。与每个平台相关的核心活动包括: a) 对 1995-2005 年登记的先证者和亲属进行系统随访,并继续对 1995-2009 年登记的所有先证者进行年度随访; b) 扩大特别关注的家庭(即多病例早发型以及 BRCA1 和 SRC/42 突变携带者)的数据和生物样本收集; c) 扩大先证者和受影响亲属的临床和预后数据收集; d) 扩大肿瘤块收集以构建组织微阵列,e) 增强现有生物样本资源并建立重复存储库; f) 扩大BRCA1和BRCA2突变检测; g) 维持和增强本地信息学能力; h) 贡献资源以促进行为和心理社会研究; i) 协调内部登记职能以及与乳腺 CFR 和外部调查人员的合作。这种增强和扩展的资源将促进广泛的研究,从识别与乳腺癌风险相关的遗传因素及其与环境和其他遗传修饰物的相互作用,到解决乳腺癌临床、行为和预防方面的转化研究。
项目成果
期刊论文数量(0)
专著数量(0)
科研奖励数量(0)
会议论文数量(0)
专利数量(0)
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{{ truncateString('ESTHER M. JOHN', 18)}}的其他基金
Risk factors for breast cancer subtypes in racial/ethnic minorities
少数种族/族裔乳腺癌亚型的危险因素
- 批准号:
9107409 - 财政年份:2015
- 资助金额:
$ 50.18万 - 项目类别:
LEGACY: A Cohort of Youth in Families from the Breast Cancer Family Registry
遗产:来自乳腺癌家庭登记处的一群年轻人
- 批准号:
8408766 - 财政年份:2011
- 资助金额:
$ 50.18万 - 项目类别:
LEGACY: A Cohort of Youth in Families from the Breast Cancer Family Registry
遗产:来自乳腺癌家庭登记处的一群年轻人
- 批准号:
8213458 - 财政年份:2011
- 资助金额:
$ 50.18万 - 项目类别:
LEGACY: A Cohort of Youth in Families from the Breast Cancer Family Registry
遗产:来自乳腺癌家庭登记处的一群年轻人
- 批准号:
8601052 - 财政年份:2011
- 资助金额:
$ 50.18万 - 项目类别:
LEGACY: A Cohort of Youth in Families from the Breast Cancer Family Registry
遗产:来自乳腺癌家庭登记处的一群年轻人
- 批准号:
8041463 - 财政年份:2011
- 资助金额:
$ 50.18万 - 项目类别:
LEGACY: A Cohort of Youth in Families from the Breast Cancer Family Registry
遗产:来自乳腺癌家庭登记处的一群年轻人
- 批准号:
8787082 - 财政年份:2011
- 资助金额:
$ 50.18万 - 项目类别:
LEGACY: A Pilot Study to Establish a Youth Cohort in the Breast CFR
遗产:建立乳腺 CFR 青年队列的试点研究
- 批准号:
7741009 - 财政年份:2009
- 资助金额:
$ 50.18万 - 项目类别:
LEGACY: A Pilot Study to Establish a Youth Cohort in the Breast CFR
遗产:建立乳腺 CFR 青年队列的试点研究
- 批准号:
7894755 - 财政年份:2009
- 资助金额:
$ 50.18万 - 项目类别:
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