LEGACY: A Pilot Study to Establish a Youth Cohort in the Breast CFR

遗产：建立乳腺 CFR 青年队列的试点研究

基本信息

批准号：
7741009
负责人：
ESTHER M. JOHN
金额：
$ 7.25万
依托单位：
CANCER PREVENTION INSTIT OF CALIFORNIA
依托单位国家：
美国
项目类别：
财政年份：
2009
资助国家：
美国
起止时间：
2009-07-16 至 2011-06-30
项目状态：
已结题

来源：
https://reporter.nih.gov/project-details/7741009
关键词：
Adolescence Adolescent Adult Age Age at Menarche American Anthropometry Area Biological Markers Birth Body Size Breast California Characteristics Child Collection DNA Methylation Data Daughter Development Diet Enrollment Environmental Exposure Epigenetic Process Ethnic Origin Etiology Exposure to Family Family history of Friends Funding Future Genes Genetic Genetic Variation Hormones Interview Life Life Style Link Malignant Neoplasms Mammary Gland Parenchyma Measurement Menarche Molecular Mothers Names Obesity Optics Parents Perinatal Perinatal Exposure Physical activity Pilot Projects Play Preparation Prevalence Procedures Questionnaires Race Recruitment Activity Risk Risk Factors Role Sampling San Francisco Self-Administered Sex Characteristics Site Social Environment Socioeconomic Status Somatotropin Spectrum Analysis Testing Time Youth aged breast cancer diagnosis breast cancer family breast cancer family registry cancer initiation cancer risk cohort design experience follow-up genetic epidemiology girls innovation lifestyle factors malignant breast neoplasm public health relevance sex

项目摘要

DESCRIPTION (provided by applicant): Epidemiologic evidence is accumulating that early-life factors may play an important role in the etiology of breast cancer. Children and adolescents may be particularly sensitive to exposures that are associated with breast cancer initiation or protection against breast cancer, thus presenting new windows of opportunity to potentially modify breast cancer risk at a young age. Identification of modifiable early-life risk factors is particularly important for girls from breast cancer families as they are at increased risk of developing breast cancer, given their family history. We are planning to establish a multi-center cohort of 1,600 girls aged 6-17 years and follow them prospectively in order to study early-life exposures (perinatal, lifestyle, and environmental exposures), as well as genetic and epigenetic factors and their effects on several endpoints related to pubertal development, including age at menarche, breast development, breast tissue characteristics, and sex and growth hormones. The cohort, named LEGACY (Lessons in Epidemiology and Genetics of Adult Cancer from Youth), will consist of girls and their mothers who are enrolled in the Breast Cancer Family Registry (BCFR) and, for comparison, girls and their mothers identified through friend controls. Thus, the cohort will be enriched with girls at increased breast cancer risk, given their family history. In preparation for establishing such a cohort, we propose to pilot test the baseline and 6-months follow-up procedures in order to 1) demonstrate feasibility of recruitment and retention in the cohort, and 2) obtain preliminary data on prevalence and variability of key endpoint and exposure variables. We will build upon a small pilot study and recruit an additional 50 girls and their mothers (30 BCFR girls and 20 friend control girls) from the San Francisco Bay area. The baseline assessment includes an interview and self-administered questionnaire, anthropometric measurements, collection of biospecimen samples, and a 7-day pedometry study. Data and biospecimen collection will be repeated 6 months after the baseline assessment. Experience gained from this pilot study will be essential for the planning and establishment of the full cohort. PUBLIC HEALTH RELEVANCE: We propose to conduct a pilot study with 50 girls aged 6-17 years and their mothers in order to demonstrate the feasibility of recruitment and retention. Experience gained from this pilot study will help establish a cohort of 1,600 girls that will be followed for 5 years in order to study early-life exposures and their effects on pubertal development.

描述（由申请人提供）：流行病学证据正在积累，即早期生活因素可能在乳腺癌的病因中起重要作用。儿童和青少年可能对与乳腺癌启动或保护乳腺癌有关的暴露尤其敏感，从而为可能在年轻时改变乳腺癌风险的新机会提供了新的机会。鉴于乳腺癌家庭的女孩，鉴定可改变的早期危险因素尤为重要，因为鉴于其家族史，乳腺癌的风险增加。我们计划建立1,600名6-17岁女孩的多中心队列，并前瞻性地跟随她们，以研究早期暴露（围产期，生活方式和环境暴露）以及遗传和表观遗传因素及其影响在与青春期发展有关的几个终点上，包括初潮的年龄，乳房发育，乳房组织特征以及性别和生长激素。该队列名为《遗产》（年轻人的成年癌症的流行病学和遗传学课程），将由女孩及其母亲组成，这些女孩及其母亲入学了乳腺癌家族注册表（BCFR），以及相比之下，女孩及其母亲是通过朋友控制所识别的。因此，鉴于她们的家族史，该队列将充满乳腺癌风险增加的女孩。为了建立这种队列的准备，我们建议试行测试基线和6个月的随访程序，以便1）证明招募和保留可行性，以及2）获得有关密钥的普遍性和差异的初步数据端点和曝光变量。我们将基于一项小型试点研究，并从旧金山湾区招募另外50名女孩及其母亲（30 BCFR女孩和20个朋友控制女孩）。基线评估包括访谈和自我管理的问卷，人体测量值，生物传感样本的收集以及7天的计量学研究。基线评估后6个月将重复数据和生物测量收集。从这项试点研究中获得的经验对于计划和建立完整的队列将是必不可少的。公共卫生相关性：我们建议对50名6-17岁的女孩及其母亲进行一项试点研究，以证明招募和保留的可行性。从这项试点研究中获得的经验将有助于建立1,600名女孩的队列，这些女孩将在5年内遵循，以研究早期生活的暴露及其对青春期发展的影响。