Risk factors for breast cancer subtypes in racial/ethnic minorities

少数种族/族裔乳腺癌亚型的危险因素

基本信息

批准号：
9107409
负责人：
ESTHER M. JOHN
金额：
$ 7.45万
依托单位：
CANCER PREVENTION INSTIT OF CALIFORNIA
依托单位国家：
美国
项目类别：
财政年份：
2015
资助国家：
美国
起止时间：
2015-07-07 至 2018-06-30
项目状态：
已结题

来源：
https://reporter.nih.gov/project-details/9107409
关键词：
Address African African American Age Alaska Native American Indians Area Asian Americans Body Size Body mass index Breast Breast Cancer Risk Factor California Cancer Etiology Characteristics Data Data Set Databases Development Diagnosis Disease Epidermal Growth Factor Receptor Estrogen Receptors Estrogen receptor negative Estrogen receptor positive Ethnic Origin Ethnic group Family Family history of Frequencies Health Heterogeneity Hispanics Hormonal Hormone Receptor Human Incidence Interview Investigation Joints Knowledge Learning Logistic Regressions Menopausal Status Minority Minority Groups Molecular Not Hispanic or Latino Pacific Island Americans Participant Population Population Control Postmenopause Prevalence Prevention strategy Primary Prevention Progesterone Receptor Status Progesterone Receptors Race Recording of previous events Reporting Resources Risk Risk Estimate Risk Factors Sample Size San Francisco Testing Tumor Markers Woman base breast cancer family registry cancer risk cancer subtypes cost data registry ethnic difference ethnic minority population lifestyle factors malignant breast neoplasm mortality neoplasm registry parity population based racial and ethnic triple-negative invasive breast carcinoma tumor

项目摘要

DESCRIPTION (provided by applicant): Racial/ethnic differences in breast cancer incidence have been well documented, yet the reasons underlying these differences are only partially understood. Relatively few studies have been conducted in racial/ethnic minority populations and some have produced findings on risk factors that are different from those reported for non-Hispanic White women. Furthermore, most studies in minority populations have assessed risk factors for breast cancer overall, despite growing evidence that breast cancer is a heterogeneous disease, with risk factors that differ for breast cancer subtypes defined by estrogen receptor (ER), progesterone receptor (PR) and human epidermal growth factor receptor-2 (HER2) status. Most currently known breast cancer risk factors apply to hormone receptor positive (ER+ and/or PR+) or Luminal A (ER+ and/or PR+, HER2) tumors. Few studies have focused on risk factors for the less common subtypes, such as hormone receptor negative (ER- PR-), triple negative (ER-PR-HER2-), or HER2 over-expressing (ER-PR-HER2+) tumors. Reports on risk factors for the less common subtypes were, with a few exceptions, based on small case numbers and included primarily non-Hispanic white women. Given that breast cancer subtypes are not equally distributed across racial/ethnic groups, with a higher incidence of aggressive subtypes in minority populations, it is important that etiologic studies in minority populations assess risk factors in relation to specific breast cancer subtypes. To address this significant gap in knowledge, we will pool existing interview and cancer registry data for 9,000 breast cancer cases and 7,855 controls who participated in five population-based studies. Participants cover a broad age range (18-79 years) and 71% of cases and 66% of controls are racial/ethnic minorities (Hispanics, Asian Americans, African Americans, non-Hispanic whites). In Aim 1, we will evaluate risk factors for breast cancer subtypes and assess heterogeneity by age and menopausal status. Using polytomous logistic regression, we will assess associations of subtypes with a broad set of risk factors, including family history of breast cancer, hormonal factors and modifiable lifestyle factors. In Aim 2, we will assess whether risk factors for the mai subtypes differ across racial/ethnic groups. Leveraging existing data, this study will provide much needed information about risk factors for the less common breast cancer subtypes and will allow direct comparison of subtype-specific risk factors across multiple racial/ethnic groups. Such information will inform the development of preventive strategies that are directly relevant for specific racial/ethnic groups.

描述（应用程序提供）：已经有充分的证明是乳腺癌发病率的种族/种族差异，但是仅部分理解了这些差异的原因。在种族/族裔少数群体中进行的研究相对较少，有些人就与非西班牙裔白人妇女报告的危险因素有所不同。此外，大多数在少数族裔人群中的研究都评估了乳腺癌总体上的危险因素，越来越多的证据证明乳腺癌是一种异质性疾病，其危险因素因雌激素受体（ER），孕酮受体（PR）和人类表皮生长因子受体-2（HER2）状态而定义的乳腺癌亚型不同。当前已知的乳腺癌危险因素适用于Homone受体阳性（ER+和/或PR+）或Luminal A（ER+和/或PR+，HER2）肿瘤。很少有研究集中在较不常见的亚型的危险因素上，例如Horsene受体阴性（ER-PR-HER2-）或HER2过表达（ER-PR-HER2+）肿瘤。关于较不常见亚型的危险因素的报告是，除了少数例外，基于小病例数，包括原发性非西班牙裔白人妇女。鉴于乳腺癌亚型并非平均分布在种族/族裔群体之间，而在少数群体中，侵略性亚型的发生率更高，因此重要的是，少数群体的病因学研究评估与特定乳腺癌亚型有关的危险因素。为了解决这一重要差距，我们将汇集9,000例乳腺癌病例的现有访谈和癌症注册表数据，以及7,855个对照，他们参加了五项基于人群的研究。参与者的年龄范围很广（18-79岁），其中71％的病例和66％的对照是种族/族裔少数民族（西班牙裔，亚裔美国人，非裔美国人，非西班牙裔白人）。在AIM 1中，我们将评估乳腺癌亚型的危险因素，并按年龄和绝经状态评估异质性。使用多种逻辑回归，我们将评估亚型与广泛危险因素的关联，包括乳腺癌的家族史，马匹因素和可修改的生活方式因素。在AIM 2中，我们将评估MAI子类型的风险因素是否在种族/族裔群体之间有所不同。利用现有数据，本研究将为较不常见的乳腺癌亚型提供有关危险因素的急需信息，并可以直接比较多个种族/族裔群体的亚型特异性风险因素。这些信息将为与特定种族/族裔群体直接相关的预防策略的制定提供信息。