Risk factors for breast cancer subtypes in racial/ethnic minorities

少数种族/族裔乳腺癌亚型的危险因素

基本信息

批准号：
9107409
负责人：
ESTHER M. JOHN
金额：
$ 7.45万
依托单位：
CANCER PREVENTION INSTIT OF CALIFORNIA
依托单位国家：
美国
项目类别：
财政年份：
2015
资助国家：
美国
起止时间：
2015-07-07 至 2018-06-30
项目状态：
已结题

来源：
https://reporter.nih.gov/project-details/9107409
关键词：
Address African African American Age Alaska Native American Indians Area Asian Americans Body Size Body mass index Breast Breast Cancer Risk Factor California Cancer Etiology Characteristics Data Data Set Databases Development Diagnosis Disease Epidermal Growth Factor Receptor Estrogen Receptors Estrogen receptor negative Estrogen receptor positive Ethnic Origin Ethnic group Family Family history of Frequencies Health Heterogeneity Hispanics Hormonal Hormone Receptor Human Incidence Interview Investigation Joints Knowledge Learning Logistic Regressions Menopausal Status Minority Minority Groups Molecular Not Hispanic or Latino Pacific Island Americans Participant Population Population Control Postmenopause Prevalence Prevention strategy Primary Prevention Progesterone Receptor Status Progesterone Receptors Race Recording of previous events Reporting Resources Risk Risk Estimate Risk Factors Sample Size San Francisco Testing Tumor Markers Woman base breast cancer family registry cancer risk cancer subtypes cost data registry ethnic difference ethnic minority population lifestyle factors malignant breast neoplasm mortality neoplasm registry parity population based racial and ethnic triple-negative invasive breast carcinoma tumor

项目摘要

DESCRIPTION (provided by applicant): Racial/ethnic differences in breast cancer incidence have been well documented, yet the reasons underlying these differences are only partially understood. Relatively few studies have been conducted in racial/ethnic minority populations and some have produced findings on risk factors that are different from those reported for non-Hispanic White women. Furthermore, most studies in minority populations have assessed risk factors for breast cancer overall, despite growing evidence that breast cancer is a heterogeneous disease, with risk factors that differ for breast cancer subtypes defined by estrogen receptor (ER), progesterone receptor (PR) and human epidermal growth factor receptor-2 (HER2) status. Most currently known breast cancer risk factors apply to hormone receptor positive (ER+ and/or PR+) or Luminal A (ER+ and/or PR+, HER2) tumors. Few studies have focused on risk factors for the less common subtypes, such as hormone receptor negative (ER- PR-), triple negative (ER-PR-HER2-), or HER2 over-expressing (ER-PR-HER2+) tumors. Reports on risk factors for the less common subtypes were, with a few exceptions, based on small case numbers and included primarily non-Hispanic white women. Given that breast cancer subtypes are not equally distributed across racial/ethnic groups, with a higher incidence of aggressive subtypes in minority populations, it is important that etiologic studies in minority populations assess risk factors in relation to specific breast cancer subtypes. To address this significant gap in knowledge, we will pool existing interview and cancer registry data for 9,000 breast cancer cases and 7,855 controls who participated in five population-based studies. Participants cover a broad age range (18-79 years) and 71% of cases and 66% of controls are racial/ethnic minorities (Hispanics, Asian Americans, African Americans, non-Hispanic whites). In Aim 1, we will evaluate risk factors for breast cancer subtypes and assess heterogeneity by age and menopausal status. Using polytomous logistic regression, we will assess associations of subtypes with a broad set of risk factors, including family history of breast cancer, hormonal factors and modifiable lifestyle factors. In Aim 2, we will assess whether risk factors for the mai subtypes differ across racial/ethnic groups. Leveraging existing data, this study will provide much needed information about risk factors for the less common breast cancer subtypes and will allow direct comparison of subtype-specific risk factors across multiple racial/ethnic groups. Such information will inform the development of preventive strategies that are directly relevant for specific racial/ethnic groups.

描述（由申请人提供）：乳腺癌发病率的种族/民族差异已得到充分记录，但对这些差异背后的原因仅部分了解，在少数种族/族裔人群中进行的研究相对较少，并且有些研究得出了风险发现。此外，尽管越来越多的证据表明乳腺癌是一种异质性疾病，并且乳腺癌亚型的危险因素有所不同，但大多数针对少数群体的研究都评估了乳腺癌的总体危险因素。由雌激素受体 (ER)、孕激素受体 (PR) 和人表皮生长因子受体 2 (HER2) 状态定义，目前已知的大多数乳腺癌危险因素适用于激素受体阳性（ER+ 和/或 PR+）或 Luminal A (ER+)。很少有研究关注不太常见亚型的危险因素，例如激素受体阴性 (ER-PR-)、三阴性 (ER-PR-HER2-) 或 HER2。过度表达（ER-PR-HER2+）肿瘤的危险因素的报告除少数例外外，都是基于小病例数，并且主要包括非西班牙裔白人女性。分布于各个种族/族裔群体中，少数群体中侵袭性亚型的发生率较高，因此少数群体的病因学研究评估与特定乳腺癌亚型相关的危险因素非常重要。为了解决这一重大知识差距，我们将汇集。现有的 9,000 例乳腺癌病例和 7,855 名对照者的访谈和癌症登记数据参与了五项基于人群的研究，参与者涵盖了广泛的年龄范围（18-79 岁），71% 的病例和 66% 的对照者是少数族裔/族裔。（西班牙裔、亚裔美国人、非裔美国人、非西班牙裔白人）在目标 1 中，我们将评估乳腺癌亚型的危险因素并评估年龄和绝经情况的异质性。使用多级逻辑回归，我们将评估亚型与一系列广泛的风险因素的关联，包括乳腺癌家族史、激素因素和可改变的生活方式因素。在目标 2 中，我们将评估主要亚型的风险因素是否不同。利用现有数据，这项研究将提供有关不太常见的乳腺癌亚型的危险因素的急需信息，并将允许直接比较多个种族/民族的亚型特定风险因素。这些信息将为制定与特定种族/族裔群体直接相关的预防策略提供信息。