Drug Resistance, Antigenic Variation And Disease Severit

耐药性、抗原变异和疾病严重程度

• 批准号: 7299938
• 负责人: Thomas E Wellems
• 金额: --
• 依托单位: NATIONAL INSTITUTE OF ALLERGY AND INFECTIOUS DISEASES
• 依托单位国家: 美国
• 资助国家: 美国
• 起止时间: 至
• 项目状态: 未结题
• 来源: https://reporter.nih.gov/project-details/7299938
• 关键词: Drug; Resistance; Antigenic; Variation; Disease

Our research program focuses on four subject areas: [1] drug resistance of malaria parasites and the factors that affect clinical outcomes after antimalarial treatment; [2] the means by which malaria parasites avoid human immune defenses; [3] why strains of the most deadly malaria parasite (Plasmodium falciparum) show different infectivities to the cells of humans and other primates; and [4] the nature of protection against malaria that is conferred to children by such hemoglobin mutations and red blood cell polymorphisms as hemoglobin C, hemoglobin S, and G6PD deficiency. In each of these areas we seek research advances that can improve the knowledge of disease processes in malaria and thereby support the development of new antimalarial chemotherapies, diagnostic tools, and vaccines. The research activities in our program are multidisciplinary and include field studies in malarious regions as well as programs of basic laboratory investigation.

我们的研究项目集中在四个学科领域：[1]疟疾寄生虫的耐药性以及抗疟治疗后影响临床结果的因素； [2] 疟原虫逃避人体免疫防御的方式； [3] 为什么最致命的疟原虫（恶性疟原虫）菌株对人类和其他灵长类动物的细胞表现出不同的感染性； [4] 血红蛋白突变和红细胞多态性（如血红蛋白 C、血红蛋白 S 和 G6PD 缺乏症）赋予儿童预防疟疾的性质。在每个领域，我们都寻求研究进展，以提高对疟疾疾病过程的了解，从而支持新的抗疟化疗、诊断工具和疫苗的开发。我们项目的研究活动是多学科的，包括疟疾地区的实地研究以及基础实验室调查项目。