Malaria Drug Resistance and Disease Virulence

疟疾耐药性和疾病毒力

• 批准号: 10692023
• 负责人: Thomas E Wellems
• 金额: $ 153.36万
• 依托单位: NATIONAL INSTITUTE OF ALLERGY AND INFECTIOUS DISEASES
• 依托单位国家: 美国
• 资助国家: 美国
• 起止时间: 至
• 项目状态: 未结题
• 来源: https://reporter.nih.gov/project-details/10692023
• 关键词: Animal Model; Antimalarials; Area; Development; Diagnostic; Diagnostic Procedure; Disease; Drug resistance; Evaluation; Genes; Human; Infection; Investigation; Knowledge; Laboratories; Malaria; Modeling; Parasites; Primates; Process; Research; Research Activity; Research Project Grants; Vaccines; Virulence; chemotherapy; drug testing; field study; human model; improved; malaria infection; multidisciplinary; nonhuman primate; novel diagnostics; novel therapeutic intervention; novel therapeutics; programs; response; treatment response; vaccine candidate

Our research project focuses on human malaria infections, therapeutic responses to antimalarial drugs, and why different strains of malaria parasites vary in their infectivities to humans and other primates. In these areas of research, we seek advances that can improve the knowledge of disease processes in malaria and thereby support the discovery and evaluation new antimalarial chemotherapies, diagnostic methods, and vaccines. The research activities in our program are multidisciplinary and include field studies in malaria-endemic regions as well as programs of basic laboratory investigation.

我们的研究项目重点关注人类疟疾感染、抗疟药物的治疗反应，以及为什么不同菌株的疟原虫对人类和其他灵长类动物的感染性不同。在这些研究领域，我们寻求能够提高对疟疾疾病过程的了解的进展，从而支持新的抗疟化疗、诊断方法和疫苗的发现和评估。我们项目的研究活动是多学科的，包括疟疾流行地区的实地研究以及基础实验室调查项目。