Genetics Of Drug Resistance, Antigenic Variation And Dis

耐药性、抗原变异和疾病的遗传学

• 批准号: 6669476
• 负责人: Thomas E Wellems
• 金额: --
• 依托单位: NATIONAL INSTITUTE OF ALLERGY AND INFECTIOUS DISEASES
• 依托单位国家: 美国
• 资助国家: 美国
• 起止时间: 至
• 项目状态: 未结题
• 来源: https://reporter.nih.gov/project-details/6669476
• 关键词: Aotus; Plasmodium falciparum; antimalarial agents; arthropod borne communicable disease; chloroquine; clinical research; diagnosis design /evaluation; drug resistance; electron microscopy; enzyme linked immunosorbent assay; gene expression; hemoglobin C; hemoglobin Ss; host organism interaction; human subject; immunoprecipitation; intracellular parasitism; linkage mapping; malaria; microorganism genetics; nucleic acid sequence; parasitic disease diagnosis; pharmacogenetics; polymerase chain reaction; protozoal antigen; quinine

Our research program focuses on determinants of drug resistance, immune evasion, and disease virulence in malaria. Investigations center on Plasmodium falciparum, the parasite that causes the most severe form of human malaria. Major projects include: (1) identification of the molecular mechanims by which malaria parasites resist such drugs as chloroquine and quinine; (2) genetics of Plasmodium falciparum infectivity and virulence in malaria; (3) characterization of the the genes responsible for malaria parasite antigenic variation and evasion of the human immune system; (4) studies of the protection conferred by hemoglobins C and S against the severe forms of falciparum malaria. Our projects involve basic research in the laboratory as well as field studies in malarious regions. Practical goals of the work are to provide fundamental information for the development of diagnostics and therapeutics against the malaria.

我们的研究项目侧重于疟疾耐药性、免疫逃避和疾病毒力的决定因素。调查的重点是恶性疟原虫，这种寄生虫会导致最严重的人类疟疾。主要项目包括：（1）疟原虫抵抗氯喹、奎宁等药物的分子机制的鉴定； (2) 恶性疟原​​虫在疟疾中的传染性和毒力的遗传学； (3) 负责疟疾寄生虫抗原变异和逃避人体免疫系统的基因的表征； (4) 血红蛋白 C 和 S 对严重形式的恶性疟疾的保护作用的研究。我们的项目涉及实验室的基础研究以及疟疾地区的实地研究。这项工作的实际目标是为开发疟疾诊断和治疗方法提供基础信息。