BIODIVERSITY IN P CARINII--MOLECULAR GENETIC ANALYSIS

P Carinii 的生物多样性--分子遗传学分析

• 批准号: 2292206
• 负责人: Francis Gigliotti
• 金额: $ 2.58万
• 依托单位: UNIVERSITY OF ROCHESTER
• 依托单位国家: 美国
• 财政年份: 1995
• 资助国家: 美国
• 起止时间: 1995-09-30 至 1998-09-29
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/2292206
• 关键词: Pneumocystis carinii; microorganism genetics; microorganism population study; protozoal antigen; systematic biology

DESCRIPTION: (Adapted from Investigator's Abstract). There is increasing data to support the view that Pneumocystis carinii is not a single species but represents a diverse group of organisms related to the fungi. This collaboration has been initiated to further our understanding of the biodiversity of P. carinii. Work is in progress at the host institution (Rochester, New York, USA) to define the antigenic characteristics of P. carinii and to determine the extent of antigenic diversity among different isolates of P. carinii. Research at the foreign site (Oxford, UK) has been involved in the analysis of the genetic diversity of different isolates of P. carinii. Collaboration between the two groups will provide both antigenic and genetic data which together will provide a powerful tool for understanding of the complexity of the group of organisms encompassed by the term P. carinii. Ultimately, this will help in the understanding of the pathogenesis of P. carinii pneumonia and the prevention and treatment of the disease. The specific aims of this collaborative arrangement are to: 1. Study the genetic diversity among isolates of P. carinii from different mammalian host species. 2. Analyze genetic diversity among isolates of P. carinii from the same mammalian host. 3. Analyze genetic diversity among isolates of P. carinii within a single infected lung.

描述：（根据研究者的摘要进行了改编）。有在增加 数据支持肺炎杆菌不是一个单一的观点 物种，但代表了与该生物相关的各种生物 真菌。这项合作已开始促进我们的 了解P. carinii的生物多样性。工作正在进行 东道国机构（美国罗切斯特）定义抗原 Carinii的特征并确定抗原的程度 Carinii不同分离株之间的多样性。研究 外国遗址（英国牛津）参与了对 Carinii不同分离株的遗传多样性。合作 两组之间将提供抗原和遗传数据 共同为理解的工具提供了强大的工具 carinii一词所包含的生物体的复杂性。 最终，这将有助于理解 Carinii P. carinii肺炎以及疾病的预防和治疗。 这种协作安排的具体目的是：1。 来自不同的Carinii分离株之间的遗传多样性 哺乳动物宿主物种。 2。分析分离株之间的遗传多样性 来自同一哺乳动物宿主的P. Carinii。 3。分析遗传多样性 在单个感染的肺中，在Cari​​nii的分离株中。