National Trends in Brain Health: a Follow-Up Study of CIND and Dementia in the US

脑健康的全国趋势：美国 CIND 和痴呆症的后续研究

• 批准号: 7942947
• 负责人: DAVID R. WEIR
• 金额: $ 47.46万
• 依托单位: UNIVERSITY OF MICHIGAN AT ANN ARBOR
• 依托单位国家: 美国
• 财政年份: 2009
• 资助国家: 美国
• 起止时间: 2009-09-30 至 2012-04-30
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/7942947
• 关键词: Age; Alzheimer' s Disease; Behavior; Behavioral; Biological; Biological Markers; Blood Pressure; Brain; C-reactive protein; Cessation of life; Child; Cholesterol; Chronic Disease; Clinical assessments; Cognition; Cognitive; Communities; Consensus; Data; Data Set; Decision Making; Dementia; Demographic Aging; Diagnosis; Economics; Elderly; Family; Family health status; Follow-Up Studies; Funding; Future; Genetic; Glycosylated hemoglobin A; Gold; Growth; Health; Health Care Costs; Healthcare Systems; Home environment; Impaired cognition; Individual; Interview; Lead; Learning; Link; Marketing; Measures; Medical; Medical Economics; Medicare; Medicare/Medicaid; Memory; Methodology; Modeling; Outcome; Parents; Performance; Physical Function; Population; Prevalence; Prevalence Study; Public Health; Public Policy; Recording of previous events; Research; Research Infrastructure; Resources; Respondent; Retirement; Risk; Risk Factors; Role; Sampling; Severities; Social Security; Societies; Speed; Spouses; Statistical Models; Surveys; Vascular Dementia; Walking; Work; base; caregiving; clinical Diagnosis; cost; disability; economic outcome; indexing; policy implication; programs; public health relevance; rapid growth; social; trend; waist circumference

DESCRIPTION (provided by applicant): We propose to study US trends in the prevalence of cognitive impairment and dementia by performing a new Aging, Demographics, and Memory Study (ADAMS 2010) that uses a similar methodology to that employed for the original NIA-funded study performed in 2001-2003. This new study will leverage the original ADAMS research team, the established national fieldwork infrastructure of the ADAMS and its parent Health and Retirement Study (HRS), and the lessons learned from the past 8 years of ADAMS work to create a unique publicly-available data resource that can be used by multi-disciplinary research teams to study the prevalence, causes, and consequences of cognitive impairment and dementia, and changes in them over the first decade of the 21st century. The specific aims of the project are to: 1) Conduct in-home clinical assessments of cognition in a sub-sample of 1000 HRS respondents age > 70, and establish a consensus diagnosis of normal, cognitive impairment without dementia (CIND), or dementia; 2) Provide to the research community a data set on the ADAMS 2010 sub-sample that contains information from the in- home assessments which can be linked to all prior and future waves of the HRS, including HRS biomarker data, HRS physical measures, Medicare administrative data, the HRS decedent interview, and the National Death Index; and 3) Use ADAMS 2010 data to derive a statistical model for assessing CIND and dementia for all HRS respondents age > 70, utilizing the cross- walk between the "gold-standard" clinical diagnoses of CIND and dementia in the ADAMS and the core HRS survey measures of cognition and physical function. This model can then be used with future HRS waves to cost-effectively track population cognitive health in the US. The proposed ADAMS 2010, in conjunction with the original ADAMS and the on-going HRS, will provide the first nationally representative data to assess the prevalence and trends of CIND and dementia in the US. Given the wide-ranging impact of CIND and dementia on individuals, families, and society, and the projected large growth in the number of older adults with dementia in the coming decades, the proposed project to create an unprecedented set of nationally-representative data that can support multi-disciplinary research on key questions regarding dementia prevalence, risk factors and outcomes is truly a "Grand Opportunity." PUBLIC HEALTH RELEVANCE: Cognitive impairment and dementia are extremely common among older adults and result in disability that generates significant costs and burdens for families, the health care system, and public programs such as Medicare, Medicaid, and Social Security. The proposed research will collect data that will lead to a better understanding of trends in the prevalence, causes, and outcomes of dementia in the US and will, therefore, have major public health and public policy implications as we now enter the period of the most rapid growth of the elderly population in our history.

描述（由申请人提供）：我们建议通过进行新的衰老，人口统计学和记忆研究（Adams 2010）来研究美国认知障碍和痴呆症患病率的趋势（Adams 2010），该方法使用了类似的方法，该方法与2001 - 2003年在2001 - 2003年进行的原始NIA资助的研究相似。 This new study will leverage the original ADAMS research team, the established national fieldwork infrastructure of the ADAMS and its parent Health and Retirement Study (HRS), and the lessons learned from the past 8 years of ADAMS work to create a unique publicly-available data resource that can be used by multi-disciplinary research teams to study the prevalence, causes, and consequences of cognitive impairment and dementia, and changes in them over the first 21世纪的十年。该项目的具体目的是：1）在1000小时受访者年龄> 70岁的子样本中对认知的家庭临床评估，并建立对正常的，认知障碍（CIND）或痴呆症的共识诊断； 2）向研究社区提供有关ADAMS 2010子样本的数据集，其中包含来自家庭评估的信息，这些信息可以与HRS的所有先前和未来浪潮有关，包括HRS Biomarker数据，HRS身体措施，医疗保险行政数据，HRS管理数据，HRS死亡访谈和国民死亡指数； 3）使用ADAMS 2010数据来得出一个统计模型，以评估所有HRS受访者> 70岁的CIND和痴呆症，并利用ADAMS中CIND和痴呆症的“金标准”临床诊断与核心HRS调查认知和物理功能的“金标准”临床诊断之间的交叉步行。然后，该模型可以与未来的HRS波一起使用，以成本效益跟踪美国的人口认知健康。拟议的Adams 2010与原始Adams和正在进行的HRS结合使用，将提供首个全国代表性数据，以评估美国CIND和痴呆症的患病率和趋势。鉴于Cind和痴呆症对个人，家庭和社会的影响很大，并且预计在未来几十年中的老年人人数会大大增长，因此拟议的项目旨在创建一套空前的国家陈述性数据，这些数据可以支持有关痴呆症患者的关键问题的多学科研究，这是一个真正的风险，风险因素和Outcomes是一个真正的机会。 公共卫生相关性：认知障碍和痴呆症在老年人中极为普遍，导致残疾，为家庭，医疗保健系统以及Medicare，Medicaid和Medicaid和社会保障等公共计划带来巨大的成本和负担。拟议的研究将收集数据，从而更好地理解美国痴呆症的患病率，原因和结果的趋势，因此，随着我们现在进入历史上老年人口最快增长的时期，将对公共卫生和公共政策产生重大影响。