Creating a National Resource for Genetic Research in Behavioral & Health Sciences

为行为遗传学研究创建国家资源

• 批准号: 8141842
• 负责人: DAVID R. WEIR
• 金额: $ 64.6万
• 依托单位: UNIVERSITY OF MICHIGAN AT ANN ARBOR
• 依托单位国家: 美国
• 财政年份: 2009
• 资助国家: 美国
• 起止时间: 2009-09-30 至 2011-12-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/8141842
• 关键词: African American; Age; Aging; American; Arts; Attention; Behavior; Behavioral; Behavioral Sciences; Bioinformatics; Biological; Biological Assay; Biological Markers; Blood; Blood Pressure; Cardiovascular Diseases; Cardiovascular system; Characteristics; Cognition; Cognitive; Cohort Studies; Collaborations; Communities; Confidentiality; Country; DNA; Data; Data Set; Databases; Development; Disease; Documentation; Economics; Epidemiologist; Future; Genetic; Genetic Materials; Genetic Research; Genomics; Genotype; Goals; Health; Health Sciences; Health behavior; Hispanics; Home visitation; House Call; Individual; Inherited; Interview; Investigation; Location; Longitudinal Studies; Measurement; Mental Health; Molecular Biology; Older Population; Participant; Peer Review; Performance; Phenotype; Policies; Population; Procedures; Process; Publications; Qualifying; Research; Research Personnel; Resources; Retirement; Risk Factors; Saliva; Sampling; Scientific Advances and Accomplishments; Secure; Signal Transduction; Social Network; Spottings; Statistical Methods; Surveys; Time; United States National Institutes of Health; base; behavioral health; cardiovascular disorder risk; cost; data management; data sharing; database of Genotypes and Phenotypes; experience; falls; gene environment interaction; genetic analysis; genetic variant; genome wide association study; human disease; middle age; public health relevance; repository; social

DESCRIPTION (provided by applicant): A Grand Opportunity for scientific advance has been created by the confluence of falling costs of genotyping, the development of statistical methods for genome-wide association studies (GWAS), and the creation of a substantial repository of genetic material on 16,000 participants in a major multi-disciplinary public-use longitudinal study of aging. The Health and Retirement Study (HRS), begun in 1992, sets the standard for data-sharing and dissemination, with over 1,000 publications by over 1,000 different authors and co-authors. Its rich measurement across domains of health, psychological characteristics, social networks, and economic status and behavior creates an unparalleled body of phenotypic data observed over time that can now be paired with a rich genotypic characterization using the Illumina 1m SNP chip. Valuable as a replication sample for many established GWA studies, this resource, building on a study already widely known in behavioral aging research, will revolutionize research on behavioral science as one of the first large-scale studies to combine genetics with behavioral phenotypes, creating a platform for discovery. Specifically, this project aims to conduct genotyping through the Center for Inherited Disease Research (CIDR) on approximately 16,000 samples derived from saliva; to make the genotype data available through dbGap with a limited array of phenotypes; to create a process for sharing genotype and broader phenotype data more widely in the research community; and to conduct a limited set of association studies with established phenotypes of cardiovascular health and cognition to demonstrate the potential of the data resource and serve as examples for future studies. The data and data-sharing mechanisms will be integrated into the ongoing HRS at the conclusion of this project. PUBLIC HEALTH RELEVANCE: This project will conduct genetic analysis on 16,000 individual participants in an ongoing longitudinal study of older Americans, and create mechanisms by which qualified researchers anywhere in the country can access the data for scientific analysis of health and behavior in the older population. It will conduct demonstration studies of genetic factors in cardiovascular health and in cognition.

描述（由申请人提供）：通过基因分型成本下降的汇合，全基因组关联研究（GWAS）的统计方法的开发以及创建对16,000名参与者的16,000名参与者的遗传材料的统计方法的开发，创造了一个巨大的科学进步机会。卫生和退休研究（HRS）始于1992年，为数据共享和传播的标准设定了标准，由1,000多名不同的作者和合着者与1000多个出版物。它在健康，心理特征，社交网络以及经济状况和行为的领域之间进行了丰富的测量，从而创造了一系列无与伦比的表型数据，随着时间的流逝，它可以使用Illumina 1M SNP芯片与丰富的基因型表征配对。作为许多已建立的GWA研究的复制样本，有价值的这一资源是基于在行为衰老研究中广为人知的研究的基础上，将彻底改变对行为科学的研究，作为将遗传学与行为表型相结合的最早的大规模研究之一，创造了发现的平台。 具体而言，该项目旨在通过遗传性疾病研究中心（CIDR）对大约16,000个来自唾液的样本进行基因分型。通过有限的表型使基因型数据可通过DBGAP获得；创建一个过程，以在研究界更广泛地共享基因型和更广泛的表型数据；并通过既定的心血管健康和认知表型进行有限的关联研究，以证明数据资源的潜力并作为未来研究的例子。数据和数据共享机制将在该项目结束时集成到正在进行的HRS中。 公共卫生相关性：该项目将对正在进行的老年人纵向研究中的16,000名参与者进行遗传分析，并创建机制，通过该机制，该国任何地方的合格研究人员可以访问数据以科学分析老年人的健康和行为。它将对心血管健康和认知中的遗传因素进行示范研究。