Expanding a National Resource for Genetic Research in Behavioral & Health Science

扩大行为遗传学研究的国家资源

• 批准号: 8142281
• 负责人: DAVID R. WEIR
• 金额: $ 32.05万
• 依托单位: UNIVERSITY OF MICHIGAN AT ANN ARBOR
• 依托单位国家: 美国
• 财政年份: 2010
• 资助国家: 美国
• 起止时间: 2010-09-30 至 2013-08-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/8142281
• 关键词: Expanding; National; Resource; Genetic; Research; Expanding; National; Resource; Genetic; Research

Abstract This project will utilize high-throughput genetic technologies in a major longitudinal behavioral study and renew the biomedical research community by building scientific partnerships for the integration of behavioral and genetic science. The 7,000 individual participants to be genotyped will be added to a database of 13,000 being constructed under an earlier ARRA project. The Health and Retirement Study (HRS), begun in 1992, sets the standard for data-sharing and dissemination, with over 1,000 publications by over 1,000 different authors and co-authors. Its rich measurement across domains of health, psychological characteristics, social networks, and economic status and behavior creates an unparalleled body of phenotypic data observed over time that can now be paired with a rich genotypic characterization of a million SNPs using the Illumina Omni1-quad beadchip. Valuable as a replication sample for many established GWA studies, this resource, building on a study already widely known in behavioral aging research, will revolutionize research on behavioral science as one of the first large-scale studies to combine genetics with behavioral phenotypes, creating a platform for discovery. Specifically, this project aims to conduct genotyping through the Center for Inherited Disease Research (CIDR) on approximately 7,000 samples derived from saliva; to make the genotype data available through dbGaP with a limited array of phenotypes; to maintain a process for sharing genotype and broader phenotype data more widely in the research community; and to conduct a limited set of association studies with established phenotypes of cardiovascular health and cognition to demonstrate the potential of the data resource and serve as examples for future studies. The data and data-sharing mechanisms will be integrated into the ongoing HRS at the conclusion of this project.

抽象的 该项目将在主要的纵向行为中利用高通量遗传技术 通过建立科学合作伙伴关系来研究和更新生物医学研究界 行为和遗传科学的整合。 7,000名个人参与者是基因分型的 将添加到一个较早的ARRA项目下构建的13,000个数据库中。这 健康与退休研究（HRS）始于1992年，为数据共享和 传播，有1,000多个不同作者和合着者的出版物。它是 跨健康，心理特征，社交网络和 经济状况和行为创造了观察到的无与伦比的表型数据 现在可以使用丰富的基因型表征对100万SNP进行配对的时间 Illumina Omni1-Quad Beadchip。作为许多已建立的GWA的复制样本有价值 研究，这一资源是基于一项在行为衰老研究中广为人知的研究的基础 将彻底改变对行为科学的研究，是最早的大规模研究之一 将遗传学与行为表型相结合，创建一个发现平台。 具体而言，该项目旨在通过遗传疾病中心进行基因分型 研究（CIDR）大约有7,000个来自唾液的样本；使基因型 通过DBGAP获得的数据，具有有限的表型；维持一个过程 在研究界，共享基因型和更广泛的表型数据；然后 与既定的心血管表型进行有限的关联研究 健康和认知以证明数据资源的潜力并作为例子 用于未来的研究。数据和数据共享机制将集成到正在进行的 HRS在该项目的结论结束时。