Harmonizing Cognitive Assessments in Irish, English, and American Longitudinal Studies: Supporting Cross-National Research on the Epidemiology of Dementia

协调爱尔兰、英国和美国纵向研究中的认知评估：支持痴呆症流行病学的跨国研究

• 批准号: 10213633
• 负责人: DAVID R. WEIR
• 金额: $ 60.69万
• 依托单位: UNIVERSITY OF MICHIGAN AT ANN ARBOR
• 依托单位国家: 美国
• 财政年份: 2019
• 资助国家: 美国
• 起止时间: 2019-09-01 至 2023-04-30
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/10213633
• 关键词: Affect; Aging; Algorithms; Alzheimer' s Disease; Alzheimer' s disease related dementia; American; Biological Markers; Blood; Cardiovascular Physiology; Cardiovascular system; Caring; Cerebrum; China; Clinic; Clinical; Cognitive; Cognitive aging; Cohort Studies; Collaborations; Collection; Communities; Complement; Conflict (Psychology); Copyright; Country; DNA Methylation; Data; Dementia; Diagnosis; Dimensions; Disease; Elderly; England; Environmental Risk Factor; Epidemiology; Epigenetic Process; Exposure to; Family; Family Study; Family health status; Foundations; Future; Genetic; Government; Great Britain; Health; Health and Retirement Study; Hearing; Home; Hour; Impaired cognition; Impairment; Incidence; India; Institutionalization; International; Interview; Ireland; Longitudinal Studies; Longitudinal cohort study; Measurement; Measures; Memory; Methylation; Mexico; Michigan; Microvascular Dysfunction; Monitor; Near-Infrared Spectroscopy; Northern Ireland; Nutrition Assessment; Older Population; Outcome; Parents; Participant; Pathway interactions; Pattern; Photography; Physiological; Politics; Population; Prevalence; Primary Prevention; Protocols documentation; Recording of previous events; Research; Research Support; Resources; Retina; Risk Factors; Sampling; Secondary Prevention; Sensory; South Africa; Stress; Structure; Surveys; Technology; Testing; Training; Trust; Universities; Validation; Vascular Dementia; Violence; Vision; Weight; base; cardiovascular health; clinical Diagnosis; clinical care; cognitive function; cognitive testing; cohort; comparative; data harmonization; data quality; data resource; data sharing; epidemiology study; experience; falls; family burden; follow-up; genomic data; health assessment; human old age (65+); improved; informant; instrument; mild cognitive impairment; modifiable risk; multidisciplinary; multisensory; neuroimaging; nutrition; patient home care; patient subsets; resilience; retinal imaging; risk variant; social; traumatic stress; trend; Affect; Aging; Algorithms; Alzheimer' s Disease; Alzheimer' s disease related dementia; American; Biological Markers; Blood; Cardiovascular Physiology; Cardiovascular system; Caring; Cerebrum; China; Clinic; Clinical; Cognitive; Cognitive aging; Cohort Studies; Collaborations; Collection; Communities; Complement; Conflict (Psychology); Copyright; Country; DNA Methylation; Data; Dementia; Diagnosis; Dimensions; Disease; Elderly; England; Environmental Risk Factor; Epidemiology; Epigenetic Process; Exposure to; Family; Family Study; Family health status; Foundations; Future; Genetic; Government; Great Britain; Health; Health and Retirement Study; Hearing; Home; Hour; Impaired cognition; Impairment; Incidence; India; Institutionalization; International; Interview; Ireland; Longitudinal Studies; Longitudinal cohort study; Measurement; Measures; Memory; Methylation; Mexico; Michigan; Microvascular Dysfunction; Monitor; Near-Infrared Spectroscopy; Northern Ireland; Nutrition Assessment; Older Population; Outcome; Parents; Participant; Pathway interactions; Pattern; Photography; Physiological; Politics; Population; Prevalence; Primary Prevention; Protocols documentation; Recording of previous events; Research; Research Support; Resources; Retina; Risk Factors; Sampling; Secondary Prevention; Sensory; South Africa; Stress; Structure; Surveys; Technology; Testing; Training; Trust; Universities; Validation; Vascular Dementia; Violence; Vision; Weight; base; cardiovascular health; clinical Diagnosis; clinical care; cognitive function; cognitive testing; cohort; comparative; data harmonization; data quality; data resource; data sharing; epidemiology study; experience; falls; family burden; follow-up; genomic data; health assessment; human old age (65+); improved; informant; instrument; mild cognitive impairment; modifiable risk; multidisciplinary; multisensory; neuroimaging; nutrition; patient home care; patient subsets; resilience; retinal imaging; risk variant; social; traumatic stress; trend

PROJECT SUMMARY This project aims to expand the resources available for cross-national research on the epidemiology of Alzheimer's disease and Alzheimer's disease related dementias (AD/ADRD). While cognitive impairment and dementia impose enormous burdens on families and governments around the world, and research is ongoing in many places, there are relatively few well-harmonized studies that allow good comparative or integrative analysis to exploit cross-national differences in determinants and outcomes of dementia. The Health and Retirement Study (HRS) family of international longitudinal studies of aging are closely harmonized on many dimensions of measurement and committed to public sharing of data to encourage research. The Harmonized Cognitive Assessment Protocol (HCAP) was developed to provide a common strong foundation to achieve more comparable assessments of impairment and dementia within this network and better harmonization to studies outside it. The HCAP has already been conducted with over 3,400 US participants in the HRS and with over 1,200 participants in the English Longitudinal Study of Ageing (ELSA). This project will add an additional 1,400 participants from the Irish Longitudinal Study of Ageing (TILDA) in the Republic of Ireland and 1,000 participants from the Northern Ireland Cohort Longitudinal Study of Ageing (NICOLA). All four studies have genomic data available to support research. As stand-alone cohorts these studies will support estimates of the prevalence of dementia and cognitive impairment in each nation and create the opportunity for future longitudinal follow-up to measure incidence rates. In conjunction with the larger samples of the parent studies they can be used to create harmonized measures of cognitive status on an even larger scale to support epidemiologic research on the full samples. Northern Ireland and the Republic share many genetic and environmental factors but the North experienced unique stress due to political violence. We will study its impact on DNA methylation and on rates of cognitive impairment and dementia. With their close association to clinical care, the Irish studies will undertake a valuable validation of the HCAP protocol against clinical diagnoses. The Irish studies bring uniquely valuable measures of cardiovascular health that can be studied for its association with dementia, including neurocardiovascular instability that is a key risk factor for falls. They also have retinal imaging that can detect cerebral microvascular disease, and detailed nutritional assessments not generally available in population-representative studies in the US.

项目摘要 该项目旨在扩大有关跨国研究的资源 阿尔茨海默氏病和阿尔茨海默氏病有关的痴呆症（AD/ADRD）。而认知障碍和 痴呆症对世界各地的家庭和政府施加了巨大的负担，研究正在进行 在许多地方，较少的良好的锻造研究允许良好的比较或综合性 分析以利用痴呆症决定因素和结果的跨国差异。健康和 国际衰老纵向研究的退休研究（HRS）对许多 测量的维度并致力于公开共享数据以鼓励研究。协调 开发认知评估方案（HCAP）是为了实现共同的强大基础 对该网络中的损害和痴呆症的更可比评估，并更好地协调 研究之外的研究。 HCAP已经与HRS的3400多名美国参与者一起进行，有1,200多个参与者 英国衰老纵向研究（ELSA）的参与者。该项目将增加1,400 来自爱尔兰共和国的爱尔兰纵向研究（TILDA）的参与者和1000 来自北爱尔兰队列的衰老纵向研究（NICOLA）的参与者。这四个研究都有 可用于支持研究的基因组数据。作为独立人群，这些研究将支持对 每个国家的痴呆症和认知障碍的患病率，并为未来创造机会 纵向随访，以测量发病率。与较大的家长研究样本结合 它们可用于在更大范围内创建认知状况的统一度量以支持 关于完整样本的流行病学研究。 北爱尔兰和共和国具有许多遗传和环境因素，但北部 由于政治暴力而造成了独特的压力。我们将研究其对DNA甲基化和速率的影响 认知障碍和痴呆症。随着他们与临床护理的紧密联系，爱尔兰研究将 根据临床诊断对HCAP方案进行有价值的验证。爱尔兰研究带来 具有独特宝贵的心血管健康措施，可以研究其与痴呆症的关联， 包括神经心血管不稳定性，这是跌倒的关键危险因素。他们还具有视网膜成像 可以检测脑微血管疾病，以及通常在 美国人口代表性研究。