Emotion processing: Risk for psychopathology

情绪处理：精神病理学风险

• 批准号: 7871079
• 负责人: SETH D POLLAK
• 金额: $ 16.14万
• 依托单位: UNIVERSITY OF WISCONSIN-MADISON
• 依托单位国家: 美国
• 财政年份: 2009
• 资助国家: 美国
• 起止时间: 2009-07-01 至 2011-06-30
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/7871079
• 关键词: 10 year old; Address; Adolescence; Adolescent; Adult; Affective; Age; Animals; Area; Behavior; Behavioral; Biological; Brain; Brain imaging; Caring; Child; Child Abuse; Child Development; Childhood; Chronic; Clinical; Cognitive; Complex; Development; Developmental Process; Emotional; Emotions; Endocrine; Ensure; Environment; Genetic; Goals; Human; Individual Differences; Intervention Trial; Knowledge; Life Experience; Linear Models; Link; Long-Term Effects; Longitudinal Studies; Measurement; Measures; Mental Health; Mental disorders; Methods; Neurobiology; Neurosecretory Systems; Outcome; Phase; Physiological; Prevention; Process; Process Measure; Psychopathology; Psychophysiology; Public Health; Recruitment Activity; Research; Research Design; Risk; Sampling; Shapes; Specific qualifier value; Stress; Sum; System; Testing; To specify; Work; base; brain behavior; design; emotion regulation; emotional experience; experience; high risk; maltreated children; neural circuit; neurodevelopment; neurophysiology; programs; research study; response; social stress

DESCRIPTION (provided by applicant): This application is the first competitive renewal of a project designed to understand the effects of abuse on children's brain-behavioral development. Studies of non-human animals have shown that adverse parental care shapes the development of the neural systems that underlie risk for mental health problems. Our work during the initial project period successfully highlighted the importance of perceptual and attentional processes as mechanisms underlying the emotional difficulties of maltreated children. This next phase of research will clarify the biological basis of these links, examine risk and protective factors, and identify the factors that place children at risk for particular forms of mental illness. The proposed work is designed to motivate development of clinical intervention trials during a subsequent project period. This application proposes to harness behavioral, cognitive neuro-physiological, anatomical, genetic, and neuro-endocrine measures to clarify the developmental mechanisms linking early stress in childhood with the emergence of mental health problems in adolescence. We will: (1) Determine the stability of the link between early stress experience and emotion processing measures across children's development; (2) Identify how specific aspects of emotion processing are associated with different forms of mental illness; (3) Specify the biological mechanisms which serve as links between children's early emotional experiences, regulation of emotion in childhood, and emergence of mental illness. Measurements will employ biological approaches including cognitive psycho-physiological, brain imaging, genetic and neuro-endocrine methods. In sum, this application proposes a continuing program of research that will examine altered emotional regulatory processes associated with child abuse and that will link these measures to mental health outcomes. This project has potential to synthesize key areas necessary to advance prevention and treatment of mental health problems in children and adults. Those include understanding the neurobiology of the brain's regulation of emotion and response to chronic social stress, the sensitivity of the human brain to contextual or environmental influences, and the ways in which the environment creates long-term effects on human behavior. Each of these foci holds tremendous promise for advancement of knowledge and application to improvement of public health.

描述（由申请人提供）：此申请是一个旨在了解虐待对儿童大脑行为发展的影响的项目的第一个竞争续约。对非人类动物的研究表明，不利的父母护理塑造了心理健康问题风险的神经系统的发展。我们在最初的项目期间的工作成功强调了感知过程和注意力过程的重要性，因为机制是虐待儿童的情感困难的基础。下一阶段的研究将阐明这些联系的生物学基础，检查风险和保护因素，并确定使儿童处于特定形式的精神疾病风险的因素。拟议的工作旨在激励在随后的项目期间开发临床干预试验。该应用建议利用行为，认知神经生理学，解剖学，遗传和神经内分泌措施，以阐明将儿童早期压力与青春期精神健康问题的出现联系起来的发育机制。我们将：（1）确定早期压力经历与儿童成长的情绪处理措施之间联系的稳定性； （2）确定情绪处理的特定方面与不同形式的精神疾病有关； （3）指定生物学机制，这些机制是儿童早期的情感经历，童年情绪的调节和精神疾病出现之间的联系。测量将采用生物学方法，包括认知心理生理学，脑成像，遗传和神经内分泌方法。总而言之，该应用程序提出了一项持续的研究计划，该计划将检查与虐待儿童有关的情绪调节过程的改变，这将把这些措施与心理健康结果联系起来。该项目有可能综合预防和治疗儿童和成人心理健康问题所需的关键领域。其中包括了解大脑对情绪的调节和对慢性社会压力的反应的神经生物学，人脑对上下文或环境影响的敏感性以及环境对人类行为产生长期影响的方式。这些焦点中的每一个都有巨大的希望，可以提高知识和应用来改善公共卫生。