BIOLOGICAL IMPRINT OF CHILDHOOD NEGLECT

童年被忽视的生物学印记

• 批准号: 7349474
• 负责人: SETH D POLLAK
• 金额: $ 2.72万
• 依托单位: UNIVERSITY OF WISCONSIN-MADISON
• 依托单位国家: 美国
• 财政年份: 2006
• 资助国家: 美国
• 起止时间: 2006-05-01 至 2007-04-30
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/7349474
• 关键词: BIOLOGICAL; IMPRINT; CHILDHOOD; NEGLECT

This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. The subproject and investigator (PI) may have received primary funding from another NIH source, and thus could be represented in other CRISP entries. The institution listed is for the Center, which is not necessarily the institution for the investigator. To determine whether hormones critical in the establishment of social bonds and regulation of emotional behaviors in children are affected by their early social experiences. The formation of social attachments is a critical component of human relationships. Infants begin to bond to their caregivers from the moment of birth, and these social bonds continue to provide regulatory emotional functions throughout adulthood. It is difficult to examine the interactions between social experience and the biological origins of these complex behaviors because children undergo both brain development and accumulate social experience at the same time. We had a rare opportunity to examine children who were reared in extremely aberrant social environments where they were deprived of the kind of care-giving typical for our species. The present experiment in nature provides insight into the role of early experience on the brain systems underlying the development of emotional behavior. These data indicate that the vasopressin and oxytocin neuropeptide systems, which are critical in the establishment of social bonds and the regulation of emotional behaviors, are affected by early social experience. The results of this experiment suggest a potential mechanism whose atypical function may explain the pervasive social and emotional difficulties observed in many children who have experienced aberrant care-giving. The present findings are consistent with the view that there is a critical role for early experience in the development of the brain systems underlying basic aspects of human social behavior. This research used techniques developed by WNPRC Assay Services.

该子项目是利用NIH/NCRR资助的中心赠款提供的资源的许多研究子项目之一。子弹和调查员（PI）可能已经从其他NIH来源获得了主要资金，因此可以在其他清晰的条目中代表。列出的机构适用于该中心，这不一定是调查员的机构。确定激素在建立社会纽带和儿童情绪行为的调节中是否受到其早期社会经历的影响。 社会依恋的形成是人际关系的关键组成部分。从出生时期开始，婴儿就开始与他们的照顾者建立联系，这些社会纽带在整个成年期继续提供监管情感功能。很难检查社会经验与这些复杂行为的生物学起源之间的相互作用，因为孩子同时经历了大脑发展和积累社会经验。我们有一个难得的机会检查在极为异常的社会环境中抚养的孩子，在这些社会环境中，他们被剥夺了我们物种的典型护理。本质上的本实验提供了对早期经验在情感行为发展的脑系统中的作用的见解。这些数据表明，加压素和催产素神经肽系统对建立社会纽带至关重要，并受到情绪行为的调节，受到早期社会经验的影响。该实验的结果表明了一种潜在的机制，其非典型功能可以解释许多经历过异常护理的儿童中观察到的普遍社会和情感困难。目前的发现与以下观点一致：早期经验在人类社会行为基本方面的大脑系统的发展中起着至关重要的作用。这项研究使用了WNPRC分析服务开发的技术。