EMOTION PROCESSING: RISK FOR PSYCHOPATHOLOGY

情绪处理：心理病理学风险

• 批准号: 8173154
• 负责人: SETH D POLLAK
• 金额: $ 3.1万
• 依托单位: UNIVERSITY OF WISCONSIN-MADISON
• 依托单位国家: 美国
• 财政年份: 2010
• 资助国家: 美国
• 起止时间: 2010-05-01 至 2011-04-30
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/8173154
• 关键词: Adolescence; Adult; Animals; Area; Behavior; Behavioral; Biological; Biological Assay; Brain; Brain imaging; Caring; Child; Child Abuse; Child Development; Childhood; Chronic; Clinical; Cognitive; Computer Retrieval of Information on Scientific Projects Database; Development; Emotional; Emotions; Endocrine; Environment; Funding; Genetic; Grant; Human; Institution; Intervention Trial; Knowledge; Link; Long-Term Effects; Measurement; Measures; Mental Health; Mental disorders; Methods; Neurobiology; Outcome; Phase; Physiological; Prevention; Process; Process Measure; Psychopathology; Psychophysiology; Public Health; Research; Research Personnel; Resources; Risk; Services; Shapes; Source; Specific qualifier value; Stress; Sum; System; United States National Institutes of Health; Work; base; design; emotion regulation; emotional experience; experience; maltreated children; neurodevelopment; programs; response; social stress

This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. The subproject and investigator (PI) may have received primary funding from another NIH source, and thus could be represented in other CRISP entries. The institution listed is for the Center, which is not necessarily the institution for the investigator. Objective: To understand the effects of abuse on children's brain-behavioral development This application is the first competitive renewal of a project designed to understand the effects of abuse on children's brain-behavioral development. Studies of non-human animals have shown that adverse parental care shapes the development of the neural systems that underlie risk for mental health problems. Our work during the initial project period successfully highlighted the importance of perceptual and attentional processes as mechanisms underlying the emotional difficulties of maltreated children. This next phase of research will clarify the biological basis of these links, examine risk and protective factors, and identify the factors that place children at risk for particular forms of mental illness. The proposed work is designed to motivate development of clinical intervention trials during a subsequent project period. This application proposes to harness behavioral, cognitive neuro-physiological, anatomical, genetic, and neuro-endocrine measures to clarify the developmental mechanisms linking early stress in childhood with the emergence of mental health problems in adolescence. We will: (1) Determine the stability of the link between early stress experience and emotion processing measures across children's development; (2) Identify how specific aspects of emotion processing are associated with different forms of mental illness; (3) Specify the biological mechanisms which serve as links between children's early emotional experiences, regulation of emotion in childhood, and emergence of mental illness. Measurements will employ biological approaches including cognitive psycho-physiological, brain imaging, genetic and neuro-endocrine methods. In sum, this application proposes a continuing program of research that will examine altered emotional regulatory processes associated with child abuse and that will link these measures to mental health outcomes. This project has potential to synthesize key areas necessary to advance prevention and treatment of mental health problems in children and adults. Those include understanding the neurobiology of the brain's regulation of emotion and response to chronic social stress, the sensitivity of the human brain to contextual or environmental influences, and the ways in which the environment creates long-term effects on human behavior. Each of these foci holds tremendous promise for advancement of knowledge and application to improvement of public health. This research relied on WNPRC Assay Services.

该子项目是利用该技术的众多研究子项目之一 资源由 NIH/NCRR 资助的中心拨款提供。子项目及 研究者 (PI) 可能已从 NIH 的另一个来源获得主要资金， 因此可以在其他 CRISP 条目中表示。列出的机构是 对于中心来说，它不一定是研究者的机构。 目的：了解虐待对儿童大脑行为发育的影响 该应用程序是旨在了解虐待对儿童大脑行为发育的影响的项目的第一个竞争性更新。对非人类动物的研究表明，不良的父母照顾会影响神经系统的发育，从而导致心理健康问题的风险。我们在项目初期的工作成功地强调了知觉和注意力过程作为受虐待儿童情绪困难的机制的重要性。下一阶段的研究将阐明这些联系的生物学基础，检查风险和保护因素，并确定使儿童面临特定形式精神疾病风险的因素。拟议的工作旨在促进后续项目期间临床干预试验的发展。该应用提出利用行为、认知神经生理学、解剖学、遗传和神经内分泌测量来阐明儿童早期压力与青春期心理健康问题的出现之间联系的发展机制。我们将：（1）确定早期压力体验与儿童发展过程中情绪处理措施之间联系的稳定性； (2) 确定情绪处理的具体方面如何与不同形式的精神疾病相关； (3)明确儿童早期情绪体验、儿童期情绪调节与精神疾病发生之间联系的生物学机制。测量将采用生物学方法，包括认知心理生理学、脑成像、遗传和神经内分泌方法。总之，本申请提出了一项持续的研究计划，该计划将检查与虐待儿童相关的情绪调节过程的改变，并将这些措施与心理健康结果联系起来。该项目有潜力综合推进儿童和成人心理健康问题预防和治疗所需的关键领域。这些包括了解大脑调节情绪和对慢性社会压力反应的神经生物学、人脑对情境或环境影响的敏感性，以及环境对人类行为产生长期影响的方式。这些焦点中的每一个都对知识的进步和应用以改善公共卫生有着巨大的希望。 这项研究依赖于 WNPRC 检测服务。