University of Utah Genetics Training Program

犹他大学遗传学培训计划

• 批准号: 10654719
• 负责人: KENT G GOLIC
• 金额: $ 58.88万
• 依托单位: UNIVERSITY OF UTAH
• 依托单位国家: 美国
• 财政年份: 2021
• 资助国家: 美国
• 起止时间: 2021-07-01 至 2026-06-30
• 项目状态: 未结题
• 来源: https://reporter.nih.gov/project-details/10654719
• 关键词: Genetic; Training Programs; Universities; Utah

PROJECT SUMMARY/ABSTRACT The proposed Genetics Training Program (UGTP) at the University of Utah (UofU) will provide in-depth training in Genetics for a diverse group of 12 predoctoral students, arming them with scientific and professional knowledge and skills needed to conduct independent and rigorous research and become leaders within the biomedical research workforce. The U of U has a well-established, successful graduate training effort in genetics research, including a long-running Genetics T32 (45 years). The proposed new UGTP is an intensive two-year program of training in quantitative analysis, rigorous and transparent experimental practices, professional skills, the ethical practice of science, mentorship, and equity/inclusivity. These foundational objectives support the development of future multi-dimensional leaders and mentors in genetics research. The UGTP engages trainees at a formative stage of their career, in their 2nd and 3rd years of graduate school. Benefits of the program extend both before and after the intensive two-year training period. Completion of a pre-requisite first year graduate curriculum covering basic transmission genetics, ethical practices in research, critical thinking, hypothesis development, and understanding of rigor and reproducibility is required for the UGTP. Students who successfully pass a Capstone Exam administered at the end of Year 1, assessing trainee potential for independent research and rigor in scientific analysis and experimental thinking, are eligible for the UGTP. Each year about 12% of the approximately 50 TGE students are selected to become trainees. Trainees convene year-round in a suite of enriching activities. The central feature of the Training Program is a seminar course led by the PDs, limited to trainees, in which the students i) present research, critically evaluate progress, and discuss scientific best practices; undertake continued training in ii) RCR and iii) rigor, transparency, and reproducibility; participate in workshops on iv) professional development, v) mentoring; and vi) recognizing and responding to biased behaviors. Trainees present their research progress annually before the entire UofU Genetics community and select and host visiting genetics speakers throughout the year. Three advanced courses in quantitative and genetics analyses provide a breadth of training in the field of Genetics. The UGTP provides continuous mentorship in research and professional development: trainees develop IDPs with the Program Directors, adopt an extra mentor from the UGTP Steering Committee who provides guidance and communication with the UGTP, and participate in events aimed at career development and building an inclusive community. Following two years of UGTP-supported research with one of 61 UGTP faculty, trainees remain engaged through a novel initiative of near-peer mentorship, a program feature that supports the scientific and cultural development and mentoring skills of our trainees. The UGTP engages the entire UofU genetics community year-round through external speakers, Concepts in Genetics Seminars, and an Annual Retreat featuring trainee talks, plenary speakers, and poster presentations from the UofU genetics community.

项目概要/摘要 犹他大学 (UofU) 拟议的遗传学培训计划 (UGTP) 将提供深入培训 为 12 名博士前学生提供遗传学博士学位，为他们提供科学和专业的知识 进行独立和严格的研究并成为该领域的领导者所需的知识和技能 生物医学研究人员。犹大大学在以下领域开展了完善、成功的研究生培训工作： 遗传学研究，包括长期运行的 Genetics T32（45 年）。拟议的新 UGTP 是一项密集的 为期两年的定量分析培训计划，严格和透明的实验实践， 专业技能、科学道德实践、指导和公平/包容性。这些基础性的 目标支持遗传学研究领域未来多维领导者和导师的发展。 UGTP 招收处于职业生涯形成阶段（研究生院第二年和第三年）的学员。 该计划的好处在两年强化培训期之前和之后都有效。完成一个 第一年研究生必修课程，涵盖基础传播遗传学、研究中的伦理实践、 批判性思维、假设发展以及对严谨性和可重复性的理解是 UGTP。成功通过第一年末举行的顶点考试的学生，评估实习生 独立研究的潜力以及科学分析和实验思维的严谨性，有资格获得 UGTP。每年约 50 名 TGE 学生中约有 12% 被选为实习生。 学员全年都会参加一系列丰富的活动。培训计划的核心特点是 由 PD 主持的研讨会课程，仅限学员参加，其中学生 i) 展示研究成果，批判性地评估 进展并讨论科学的最佳实践；接受 ii) RCR 和 iii) 严格性的持续培训， 透明度和可重复性；参加有关 iv) 专业发展、v) 指导的研讨会；和 vi) 识别并应对偏见行为。学员每年都会在之前展示他们的研究进展 整个 UofU 遗传学社区，并全年选择和接待客座遗传学演讲者。三 定量和遗传学分析高级课程提供遗传学领域的广泛培训。 UGTP 提供研究和专业发展方面的持续指导：学员培养 IDP 与项目主管一起，从 UGTP 指导委员会中聘请一位额外的导师来提供指导 与 UGTP 进行沟通，并参加旨在职业发展和建立良好关系的活动 包容性社区。经过两年 UGTP 支持的研究，其中 61 名 UGTP 教师、实习生之一 通过近同伴指导的新颖举措保持参与，这是一项支持 学员的科学和文化发展以及指导技能。 UGTP 吸引了整个 UofU 的参与 遗传学界全年通过外部演讲者、遗传学概念研讨会和年度会议 静修活动包括来自 UofU 遗传学界的实习生演讲、全体演讲和海报展示。

项目成果

FoxA1/2-dependent epigenomic reprogramming drives lineage switching in lung adenocarcinoma.

FoxA1/2 依赖性表观基因组重编程驱动肺腺癌谱系转换。

• 发表时间: 2023-11-02
• 作者: Gillis, Katherine;Orellana, Walter A;Wilson, Emily;Parnell, Timothy J;Fort, Gabriela;Dadzie, Headtlove Essel;Zhang, Xiaoyang;Snyder, Eric L
• 通讯作者: Snyder, Eric L

Dicentric chromosome breakage in Drosophila melanogaster is influenced by pericentric heterochromatin and occurs in nonconserved hotspots.

果蝇的双着丝粒染色体断裂受到中心周异染色质的影响，并发生在非保守热点中。

• 发表时间: 2023-05-26
• 影响因子: 3.3
• 作者: Hill, Hunter J;Bonser, Danielle;Golic, Kent G
• 通讯作者: Golic, Kent G

The desert woodrat (Neotoma lepida) induces a diversity of biotransformation genes in response to creosote bush resin.

沙漠林鼠（Neotoma lepida）响应杂酚油灌木树脂而诱导多种生物转化基因。

• 发表时间: 2024-06
• 作者: Greenhalgh, Robert;Klure, Dylan M;Orr, Teri J;Armstrong, Noah M;Shapiro, Michael D;Dearing, M Denise
• 通讯作者: Dearing, M Denise

Integrating Precision Medicine into the Standard of Care for Male Infertility: What Will it Take?

将精准医学纳入男性不育症的护理标准：需要做什么？

• DOI: 10.1016/j.eururo.2022.06.015
• 发表时间: 2022-07-01
• 期刊: European urology
• 影响因子: 23.4
• 作者: J. Kunisaki;A. Quinlan;K. Aston;Jim Hotaling
• 通讯作者: Jim Hotaling

Histone 4 lysine 5/12 acetylation enables developmental plasticity of Pristionchus mouth form.

组蛋白 4 赖氨酸 5/12 乙酰化使 Pristionchus 口腔形态具有发育可塑性。

• 发表时间: 2023-04-13
• 影响因子: 16.6
• 作者: Werner, Michael S;Loschko, Tobias;King, Thomas;Reich, Shelley;Theska, Tobias;Franz;Macek, Boris;Sommer, Ralf J
• 通讯作者: Sommer, Ralf J