Strengthening Data Science Capacity for Biomedical Research Advancement at Hawaii

加强夏威夷生物医学研究进展的数据科学能力

• 批准号: 10872087
• 负责人: Joseph Keawe'aimoku Kaholokula
• 金额: $ 39.13万
• 依托单位: UNIVERSITY OF HAWAII AT MANOA
• 依托单位国家: 美国
• 财政年份: 2021
• 资助国家: 美国
• 起止时间: 2021-09-01 至 2026-07-31
• 项目状态: 未结题
• 来源: https://reporter.nih.gov/project-details/10872087
• 关键词: Acceleration; Address; Adoption; Affect; Asian population; Biomedical Research; Biometry; Budgets; COVID-19 pandemic; Clinical Investigator; Clinical Research; Communication; Communities; Community Outreach; Data; Data Science; Death Rate; Development; Dissemination and Implementation; Doctor of Philosophy; Economics; Ensure; Environment; Epidemiology; Ethnic Population; Evaluation; Face; Filipino; Fostering; Funding; Hawaii; Hawaiian; Health; Health Personnel; Health Promotion; Homelessness; Human; Indigenous; Institution; Institutionalization; Intervention; Investments; Knowledge; Lead; Left; Life; Longevity; Mental Health; Mentors; Native Hawaiian or Other Pacific Islander; Participant; Personal Satisfaction; Persons; Pilot Projects; Policies; Population; Poverty; Reduce health disparities; Registries; Research; Research Activity; Research Design; Research Infrastructure; Research Personnel; Resources; Rural; Science; Sexual and Gender Minorities; Translational Research; Trust; Underinsured; Underserved Population; Unemployment; Uninsured; United States; United States National Institutes of Health; Universities; Vulnerable Populations; career; clinical development; community engagement; community organizations; disorder prevention; efficacy study; evidence base; health care availability; health disparity; health disparity populations; implementation strategy; improved; innovation; marginalized community; medically underserved population; operation; physical conditioning; programs; racial population; research study; rural area; social health determinants; socioeconomics; success; symposium; underserved community; unhealthy lifestyle; user-friendly

The Center for Pacific Innovations, Knowledge, and Opportunities (PIKO) will build a statewide clinical and translational research (CTR) infrastructure to improve the health of Indigenous Pacific People (IPP) – defined as Native Hawaiians, Other Pacific Islanders, and Filipinos. IPP comprise 40% of Hawaii’s population and have disproportionately high rates of physical and mental health conditions compared to Whites and Asians. They also make up a majority of Hawaii’s other medically underserved and vulnerable populations. PIKO represents a partnership between the University of Hawaii (lead), Hawaii Pacific University, Chaminade University of Honolulu, and a statewide network of practice-based organizations (PBO) and community-based organizations (CBO). PIKO emphasizes the T3 (efficacy studies) to T5 (adoption and institutionalization) domains of CTR where the social determinants of health are strongly operative. PIKO takes a team-science approach to transform current CTR paradigms and to accelerate CTR advances to improve IPP health. PIKO comprises seven Cores: Administrative; Professional Development; Pilot Projects Program; Biostatistics, Epidemiology, and Research Design; Community Engagement and Outreach; Clinical Research and Regulatory Support; and Tracking and Evaluation. The University of Hawaii committed $2 million over 5 years to PIKO. The Overall Specific Aims are: Specific Aim 1: Build a robust CTR infrastructure by establishing and implementing CTR activities within and across PIKO partnering institutions; by leveraging resources and expertise of other research infrastructure programs; by creating CTR registries of academic mentors, community leaders, junior investigators, and study participants; and by implementing efficient and effective administrative operations and communication strategies. Specific Aim 2: Strengthen and diversify the CTR workforce by identifying IPP and non-IPP investigators for CTR careers; by enhancing the mentoring and professional development of CTR investigators and community leaders; by supporting culturally responsive and scientifically meritorious CTR pilot projects; and by engaging PBO/CBO to actively participate on all aspects of CTR. Specific Aim 3: Disseminate and implement CTR findings by providing strategic investments in PBO/CBO to strengthen trust-based relationships; by strengthening a statewide network of PBO/CBO to serve as dissemination and implementation partners; by convening an annual conference that brings together CTR investigators and PBO/CBO stakeholders to share best practices, discoveries, and dissemination and implementation strategies; and by leveraging data science strategies to disseminate data and findings that are user-friendly, easy to understand, and accessible. By the end of this 5-year project, PIKO will have promoted high-impact transformative CTR to improve the health of IPP and other marginalized communities in Hawaii.

太平洋创新，知识和机会中心（Piko）将建立一个全州临床， 转化研究（CTR）基础设施以改善土著太平洋人（IPP）的健康状况 - 定义为 夏威夷原住民，其他太平洋岛民和菲律宾人。 IPP占夏威夷人口的40％，拥有 与白人和亚洲人相比，身心健康状况的比例不成比例。他们 还构成了夏威夷其他医疗贫困和脆弱的人群的大部分。 Piko代表 夏威夷大学，夏威夷太平洋大学的夏威夷大学，夏威夷大学的合作伙伴关系 檀香山，以及全州基于实践组织（PBO）和社区组织的网络 （CBO）。 Piko强调CTR的T3（功效研究）（采用和制度化）领域 健康的社会决定者强烈运作。皮科采用团队科学方法来转变 当前的CTR范式并加速CTR的进步以改善IPP健康。 Piko包括七个核心： 行政;专业发展；试点项目计划；生物统计学，流行病学和研究 设计;社区参与和宣传；临床研究和监管支持；和跟踪和 评估。夏威夷大学在5年内向皮科承诺了200万美元。总体具体目的是： 特定目标1：通过在内部建立和实施CTR活动来建立强大的CTR基础架构 以及整个Piko合作机构；通过利用其他研究基础设施的资源和专业知识 程序；通过创建学术导师，社区领导者，初级调查人员的CTR注册机构，并研究 参与者；并通过实施高效有效的行政操作和沟通策略。 特定目的2：通过识别IPP和非ipp调查人员来增强和多样化CTR劳动力 对于CTR职业；通过增强CTR调查人员和社区的心理和专业发展 领导者；通过支持文化响应迅速且科学上的CTR试点项目；并通过参与 PBO/CBO积极参与CTR的各个方面。 特定目的3：通过提供战略投资来传播和实施CTR调查结果 PBO/CBO加强基于信任的关系；通过加强全州PBO/CBO网络以服务 作为传播和实施伙伴；通过召集年度会议，将CTR汇集在一起 调查人员和PBO/CBO利益相关者分享最佳实践，发现和传播以及 实施策略；并利用数据科学策略来传播数据和发现 用户友好，易于理解和访问。 到这个5年的项目结束时，Piko将促进高影响力的变革性CTR来改善 IPP和夏威夷边缘化社区的健康状况。

项目成果

Living Well With Kidney Disease and Effective Symptom Management: Consensus Conference Proceedings.

• DOI: 10.1016/j.ekir.2022.06.015
• 发表时间: 2022-09
• 期刊: KIDNEY INTERNATIONAL REPORTS
• 影响因子: 6
• 作者: Rhee, Connie M.;Edwards, Dawn;Ahdoot, Rebecca S.;Burton, James O.;Conway, Paul T.;Fishbane, Steven;Gallego, Daniel;Gallieni, Maurizio;Gedney, Nieltje;Hayashida, Glen;Ingelfinger, Julie;Kataoka-Yahiro, Merle;Knight, Richard;Kopple, Joel D.;Kumarsawami, Latha;Lockwood, Mark B.;Murea, Mariana;Page, Victoria;Sanchez, J. Emilio;Szepietowski, Jacek C.;Lui, Siu-Fai;Kalantar-Zadeh, Kamyar
• 通讯作者: Kalantar-Zadeh, Kamyar

Wellbeing for all: Indigenizing theories and measures of wellbeing for equitable sustainability.

• DOI: 10.3389/fpsyg.2022.979109
• 发表时间: 2022
• 期刊: FRONTIERS IN PSYCHOLOGY
• 影响因子: 3.8
• 作者: Qina'au, Joanne;Antonio, Mapuana C. K.
• 通讯作者: Antonio, Mapuana C. K.

Identification and Implications of HIV-1 CRF01_AE Subtype in Hawai'i.

• 发表时间: 2022-08
• 期刊: Hawai'i journal of health & social welfare
• 作者: Logan S. Dean;I. SahBandar;C. Shikuma

Cost Effectiveness of a Cultural Physical Activity Intervention to Reduce Blood Pressure Among Native Hawaiians with Hypertension.

• DOI: 10.1007/s41669-021-00291-6
• 发表时间: 2022-01
• 期刊: PharmacoEconomics - open
• 作者: Railey AF;Muller C;Noonan C;Schmitter-Edgecombe M;Sinclair K;Kim C;Look M;Kaholokula JK
• 通讯作者: Kaholokula JK

Scoping Review of Interventional Studies in Chronic Disease for Native Hawaiian, Pacific Islander, and Filipino Populations in the United States.

美国夏威夷原住民、太平洋岛民和菲律宾人群慢性病干预研究范围审查。

• 发表时间: 2023
• 期刊: Hawai'i journal of health & social welfare
• 作者: Taafaki,MunirihR;Taira,Deborah;Braun,KathrynL
• 通讯作者: Braun,KathrynL