Extensible Open Source Zero-Footprint Web Viewer for Cancer Imaging Research

用于癌症成像研究的可扩展开源零足迹 Web 查看器

• 批准号: 10644112
• 负责人: GORDON J HARRIS
• 金额: $ 76.97万
• 依托单位: MASSACHUSETTS GENERAL HOSPITAL
• 依托单位国家: 美国
• 财政年份: 2023
• 资助国家: 美国
• 起止时间: 2023-05-01 至 2028-04-30
• 项目状态: 未结题
• 来源: https://reporter.nih.gov/project-details/10644112
• 关键词: Acceleration; Address; Adopted; Adoption; Awareness; Breast; Cancer Center; Cancer Research Infrastructure; Categories; Client; Clinical Trials; Cloud Computing; Collaborations; Communities; Computer software; Computers; Custom; Data; Data Set; Data Sources; Development; Development Plans; Digital Imaging and Communications in Medicine; Disease; Disease Progression; Documentation; Dose; Ensure; Environment; Feedback; Focus Groups; Fostering; Foundations; Friends; Functional Imaging; Funding; Funding Agency; Goals; Grant; Guidelines; Health; Hospitals; Image; Image Analysis; Imaging Device; Industry; Informatics; Infrastructure; Internet; Libraries; Longevity; Malignant Neoplasms; Maps; Masks; Medical Imaging; Methods; Monitor; Nature; Online Systems; Patient imaging; Positron-Emission Tomography; Privatization; Production; Radiation therapy; Research; Research Personnel; Research Project Grants; Resources; Series; Side; Site; Slide; Structure; System; Technology; TensorFlow; Training; Translating; Translations; Update; Visualization; anticancer research; base; cancer imaging; clinical practice; clinical translation; cloud based; design; experience; flexibility; hackathon; image registration; image visualization; imaging informatics; imaging modality; implementation process; improved; innovation; machine learning framework; meetings; microscopic imaging; molecular imaging; multimodality; novel; open source; outreach; prototype; symposium; tomosynthesis; tool; transmission process; treatment response; trend; usability; user-friendly; web platform; web-based tool; web-enabled; webinar

Project Summary/Abstract The Open Health Imaging Foundation (OHIF) Viewer and its underlying libraries such as Cornerstone have become the standard framework for web-based imaging informatics technologies in cancer research and beyond, supporting hundreds of open-source projects with thousands of users. Through OHIF, developers can: 1) add new innovative tools as extensions to the OHIF Viewer; 2) use specific OHIF modules or libraries to build their own custom tools; and 3) web-enable existing desktop informatics platforms. To support the transition from desktop to web-based tools, researchers need well-supported frameworks to build upon. Currently, many cancer research image viewers require software to be installed on each user's local workstation, a drawback which limits accessibility and ease of collaboration. Most web-viewers available today are either proprietary, closed systems, or open-source research applications that use legacy technologies. For cancer imaging research that requires multi-site collaboration, there is a growing need for a framework that can enable researchers to review images and collaborate with colleagues remotely. OHIF’s zero-footprint web- viewer tools provide enormous usability benefits for end users, who gain instant access to view data across computers without any software to install or update. Under a prior NCI ITCR U24 grant, we developed the OHIF Framework, which provides a professional- grade, free, open-source web-based imaging environment for cancer research with image review, annotation functionality, and a user-friendly interface. The OHIF Viewer relies on standards, which has enabled easy integration with other systems, and it can be extended to provide custom functionality without modifying the core application. Additionally, its components can be re-used to rapidly develop new applications and help enable the transition to cloud computing for cancer research tools. The core goal of this proposal is to enhance and sustain the OHIF platform and broaden the user and contributor base of this technology. The current project has three aims: 1) extend the web-viewer’s cancer imaging visualization and analysis capabilities; 2) reduce barriers to adoption by creating ready-to-use installers for on-premises and cloud-hosted deployment; and 3) expand our support infrastructure for the cancer research community. For community support, we will enhance our outreach, engagement, and support initiatives to foster collaboration with developers and end users. In order to facilitate clinical translation and share our experience with regulatory compliance, we will implement a quality management system (QMS) for core OHIF framework development and regularly release design documentation to the community. Enhancing the platform's functionality, easing installation, and enriching support will allow researchers to better collaborate to evaluate the nature of cancer disease progression and response to treatment. With the widespread adoption of the OHIF platform to date, the impact of these improvements will be far reaching.

项目摘要/摘要 开放健康成像基金会（OHIF）的观众及其基础图书馆（例如Cornerstone） 成为癌症研究中基于Web的成像信息技术的标准框架和 除了支持数百个用户，还支持数百个开源项目。通过OHIF，开发人员可以： 1）将新的创新工具添加为OHIF查看器的扩展； 2）使用特定的OHIF模块或库 建立自己的自定义工具； 3）可启用Web的现有桌面信息平台。支持 从桌面到基于网络的工具的过渡，研究人员需要建立良好的支持框架。 目前，许多癌症研究图像查看器要求将软件安装在每个用户的本地 工作站，限制可访问性和易于协作的缺点。今天可用的大多数网络视角 是使用传统技术的专有，封闭系统或开源研究应用程序。为了 需要多站点协作的癌症成像研究，对一个可以越来越多的框架需要 使研究人员能够远程审查图像并与同事合作。 OHIF的零英尺web- 查看器工具为最终用户提供了巨大的可用性利益，他们可以立即访问跨越查看数据 没有任何软件安装或更新的计算机。 根据先前的NCI ITCR U24赠款，我们开发了OHIF框架，该框架提供了专业 带有图像审查的癌症研究的等级，免费的，开源的基于网络的成像环境，注释 功能和用户友好的接口。 OHIF查看器依赖于标准，该标准已启用 与其他系统集成，可以扩展以提供自定义功能，而无需修改 核心应用程序。此外，可以重新使用其组件以快速开发新的应用程序并提供帮助 使癌症研究工具的云计算过渡。 该建议的核心目标是增强和维持OHIF平台，并扩大用户和 该技术的贡献者基础。当前项目有三个目的：1）扩展网络观看者的癌症 成像可视化和分析功能； 2）通过创建现成的使用来减少采用障碍 用于本地和云托管部署的安装程序； 3）扩大我们的支持基础架构 癌症研究界。为了获得社区支持，我们将增强我们的外展，参与和支持 促进与开发人员和最终用户合作的举措。为了促进临床翻译和 分享我们在法规合规性方面的经验，我们将实施一个质量管理系统（QMS） 核心OHIF框架开发并定期向社区发布设计文档。 增强平台的功能，放松安装和丰富的支持将使研究人员允许 更好地协作以评估癌症疾病进展的性质和对治疗的反应。与 迄今为止，宽度采用了OHIF平台，这些改进的影响将达到遥远的影响。