Extensible Open Source Zero-Footprint Web Viewer for Cancer Imaging Research

用于癌症成像研究的可扩展开源零足迹 Web 查看器

• 批准号: 10644112
• 负责人: GORDON J HARRIS
• 金额: $ 76.97万
• 依托单位: MASSACHUSETTS GENERAL HOSPITAL
• 依托单位国家: 美国
• 财政年份: 2023
• 资助国家: 美国
• 起止时间: 2023-05-01 至 2028-04-30
• 项目状态: 未结题
• 来源: https://reporter.nih.gov/project-details/10644112
• 关键词: Acceleration; Address; Adopted; Adoption; Awareness; Breast; Cancer Center; Cancer Research Infrastructure; Categories; Client; Clinical Trials; Cloud Computing; Collaborations; Communities; Computer software; Computers; Custom; Data; Data Set; Data Sources; Development; Development Plans; Digital Imaging and Communications in Medicine; Disease; Disease Progression; Documentation; Dose; Ensure; Environment; Feedback; Focus Groups; Fostering; Foundations; Friends; Functional Imaging; Funding; Funding Agency; Goals; Grant; Guidelines; Health; Hospitals; Image; Image Analysis; Imaging Device; Industry; Informatics; Infrastructure; Internet; Libraries; Longevity; Malignant Neoplasms; Maps; Masks; Medical Imaging; Methods; Monitor; Nature; Online Systems; Patient imaging; Positron-Emission Tomography; Privatization; Production; Radiation therapy; Research; Research Personnel; Research Project Grants; Resources; Series; Side; Site; Slide; Structure; System; Technology; TensorFlow; Training; Translating; Translations; Update; Visualization; anticancer research; base; cancer imaging; clinical practice; clinical translation; cloud based; design; experience; flexibility; hackathon; image registration; image visualization; imaging informatics; imaging modality; implementation process; improved; innovation; machine learning framework; meetings; microscopic imaging; molecular imaging; multimodality; novel; open source; outreach; prototype; symposium; tomosynthesis; tool; transmission process; treatment response; trend; usability; user-friendly; web platform; web-based tool; web-enabled; webinar

Project Summary/Abstract The Open Health Imaging Foundation (OHIF) Viewer and its underlying libraries such as Cornerstone have become the standard framework for web-based imaging informatics technologies in cancer research and beyond, supporting hundreds of open-source projects with thousands of users. Through OHIF, developers can: 1) add new innovative tools as extensions to the OHIF Viewer; 2) use specific OHIF modules or libraries to build their own custom tools; and 3) web-enable existing desktop informatics platforms. To support the transition from desktop to web-based tools, researchers need well-supported frameworks to build upon. Currently, many cancer research image viewers require software to be installed on each user's local workstation, a drawback which limits accessibility and ease of collaboration. Most web-viewers available today are either proprietary, closed systems, or open-source research applications that use legacy technologies. For cancer imaging research that requires multi-site collaboration, there is a growing need for a framework that can enable researchers to review images and collaborate with colleagues remotely. OHIF’s zero-footprint web- viewer tools provide enormous usability benefits for end users, who gain instant access to view data across computers without any software to install or update. Under a prior NCI ITCR U24 grant, we developed the OHIF Framework, which provides a professional- grade, free, open-source web-based imaging environment for cancer research with image review, annotation functionality, and a user-friendly interface. The OHIF Viewer relies on standards, which has enabled easy integration with other systems, and it can be extended to provide custom functionality without modifying the core application. Additionally, its components can be re-used to rapidly develop new applications and help enable the transition to cloud computing for cancer research tools. The core goal of this proposal is to enhance and sustain the OHIF platform and broaden the user and contributor base of this technology. The current project has three aims: 1) extend the web-viewer’s cancer imaging visualization and analysis capabilities; 2) reduce barriers to adoption by creating ready-to-use installers for on-premises and cloud-hosted deployment; and 3) expand our support infrastructure for the cancer research community. For community support, we will enhance our outreach, engagement, and support initiatives to foster collaboration with developers and end users. In order to facilitate clinical translation and share our experience with regulatory compliance, we will implement a quality management system (QMS) for core OHIF framework development and regularly release design documentation to the community. Enhancing the platform's functionality, easing installation, and enriching support will allow researchers to better collaborate to evaluate the nature of cancer disease progression and response to treatment. With the widespread adoption of the OHIF platform to date, the impact of these improvements will be far reaching.

项目概要/摘要 开放健康成像基金会 (OHIF) Viewer 及其底层库（例如 Cornerstone）具有 成为癌症研究中基于网络的成像信息学技术的标准框架 除此之外，通过 OHIF 支持数百个开源项目，开发人员可以： 1) 添加新的创新工具作为 OHIF 查看器的扩展；2) 使用特定的 OHIF 模块或库 构建自己的定制工具；3) 支持网络的现有桌面信息学平台。 从桌面工具过渡到基于网络的工具，研究人员需要良好支持的框架来构建。 目前，许多癌症研究图像查看器需要在每个用户的本地安装软件 工作站，这是限制当今大多数网络查看器的可访问性和易用性的缺点。 要么是专有的、封闭的系统，要么是使用遗留技术的开源研究应用程序。 由于癌症成像研究需要多站点协作，因此越来越需要一个能够 使研究人员能够查看图像并与同事远程协作 OHIF 的零足迹网络。 查看器工具为最终用户提供了巨大的可用性优势，他们可以即时访问以查看跨平台的数据 没有任何软件需要安装或更新的计算机。 在之前的 NCI ITCR U24 资助下，我们开发了 OHIF 框架，该框架提供了专业的 用于癌症研究的、免费的、开源的基于网络的成像环境，具有图像审查、注释功能 OHIF 查看器依赖于标准，这使得操作变得简单。 与其他系统集成，并且可以扩展以提供自定义功能，而无需修改 此外，它的组件可以重复使用以快速开发新应用程序并提供帮助。 实现癌症研究工具向云计算的过渡。 该提案的核心目标是增强和维持 OHIF 平台并扩大用户和 该技术的贡献者群体当前的项目有三个目标：1）延长网络浏览者的癌症范围。 成像可视化和分析功能；2) 通过创建即用型产品来减少采用障碍 用于本地和云托管部署的安装程序；3) 扩展我们的支持基础设施 对于癌症研究社区的支持，我们将加强我们的外展、参与和支持。 促进与开发人员和最终用户合作的举措，以促进临床翻译和 分享我们在法规遵从方面的经验，我们将实施质量管理体系（QMS） 核心 OHIF 框架开发并定期向社区发布设计文档。 增强平台的功能、简化安装并丰富支持将使研究人员能够 更好地合作评估癌症疾病进展的性质和对治疗的反应。 迄今为止，OHIF 平台已得到广泛采用，这些改进的影响将是深远的。