Extensible open-source zero-footprint web viewer for oncologic imaging research

用于肿瘤成像研究的可扩展开源零足迹 Web 查看器

• 批准号: 9324177
• 负责人: GORDON J HARRIS
• 金额: $ 65.52万
• 依托单位: MASSACHUSETTS GENERAL HOSPITAL
• 依托单位国家: 美国
• 财政年份: 2015
• 资助国家: 美国
• 起止时间: 2015-09-15 至 2020-08-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/9324177
• 关键词: Address; Adoption; Architecture; Award; Cancer Center; Cancer Center Support Grant; Cancer Research Project; Client; Clinical Oncology; Clinical Trials; Code; Communities; Community Clinical Oncology Program; Complex; Computer software; Computers; Consultations; Databases; Development; Electronic Mail; Environment; Funding; Goals; Grant; Health Insurance Portability and Accountability Act; Hospitals; Image; Image Analysis; Industry; Informatics; Institutes; Internet; Knowledge; Link; Location; Maintenance; Malignant Neoplasms; Measurement; Medical; Medical Imaging; Modernization; Oncologist; Online Systems; Patients; Plug-in; Positioning Attribute; Principal Investigator; Protocols documentation; Radiology Specialty; Reporting; Research; Research Personnel; Research Project Grants; Resource Sharing; Resources; Security; Services; Side; Software Design; Software Framework; Source Code; System; Technology; Time; Update; Utah; Vendor; Work; anticancer research; base; cancer care; cancer imaging; cost; design; digital imaging; experience; flexibility; handheld mobile device; imaging software; imaging system; interest; oncology; open source; preference; programs; public health relevance; radiologist; software development; technology development; tool; tool development; tumor; web app; web site

 DESCRIPTION (provided by principal investigator): Managing the increasingly complex workflow and imaging analyses for oncology clinical trials to provide timely, protocol-compliant assessments requires sophisticated informatics tools. To address these issues, over the past 10 years the Tumor Imaging Metrics Core (TIMC), a CCSG Shared-Resource of the Dana-Farber/Harvard Cancer Center (DF/HCC), has developed a software informatics system for managing the workflow and image measurements for oncology clinical trials. This system currently is in use across the 5 DF/HCC Harvard hospitals to manage over 600 active clinical trials, with 800 users, and has been licensed and implemented at several other Cancer Centers, including Yale, Utah/Huntsman Cancer Institute, and UW/Seattle Cancer Care Alliance. The workflow management informatics system includes a web-application/database for protocol registration, order entry, work list management, reporting, and billing/administrative functions. However, the integrated, open-source image analysis platform is workstation-based and needs to be installed and updated on each computer where imaging measurements will be performed. Thus, the open- source imaging system is a limiting factor in deployment, requiring added IT desktop support and maintenance at each location where imaging assessments will be performed. The widespread adoption of this system across NCI Cancer Centers will be aided and facilitated by adapting the image analysis functionality into a web-based open-source platform. The current proposal is to 1) create a vendor-neutral, open-source, extensible, zero-footprint web-viewer and supporting server for display and analysis of DICOM images, and 2) create a plug-in architecture to allow us to replace our current open-source image workstation with this zero-footprint web-viewer for our TIMC clinical trials management system. In order to make the system broadly available to the oncology research community, in addition to developing an interface to our TIMC web-application, we will also implement an AIM (Annotation and Image Markup) interface so that caBIG investigators and other AIM framework research projects can integrate easily with our web-viewer. The viewer will meet all of the basic requirements for radiology tumor measurements specific to the needs of oncology clinical trials, yet also be flexible enough to be configured for user preferences and extended via plug-ins to support varied research workflows as a shared research resource. To achieve these design goals, the viewer and all of its functionality will be delivered to client machines exclusively through the web browser with nothing to install on client computers or mobile devices, which greatly simplifies and reduces the cost and support requirements of software deployments, and increases accessibility. The proposed viewer will enable researchers, imaging software developers, clinicians, and patients to access oncology clinical trials images in a freely availabl and openly extensible environment. This will facilitate remote image viewing and collaborative image consultations among a wide-range of imaging professionals. The web-DICOM viewer will be fully integrated with the TIMC clinical trials informatics management system so that both systems can be deployed across NCI Cancer Centers in a completely web-based implementation without desktop IT support. An AIM interface will also be provided so that the web-viewer can be integrated broadly across the caBIG/AIM cancer research community.

 描述（由首席研究员提供）：管理肿瘤学临床试验日益复杂的工作流程和成像分析，以提供及时、符合方案的评估，需要复杂的信息学工具来解决这些问题，在过去的 10 年里，肿瘤成像指标核心（TIMC）。 ）是丹娜—法伯癌症中心 (DF/HCC) 的 CCSG 共享资源，开发了一个软件信息学系统，用于管理肿瘤临床工作流程和图像测量该系统目前在哈佛大学的 5 家 DF/HCC 医院中使用，管理 600 多项活跃的临床试验，共有 800 名用户，并已在其他几个癌症中心获得许可并实施，包括耶鲁大学、犹他州/亨斯曼癌症研究所和华盛顿大学/西雅图癌症护理联盟。工作流程管理信息系统包括用于协议注册、订单输入、工作列表管理、报告和计费/管理功能的网络应用程序/数据库。开源图像分析平台是基于工作站的，需要在每台进行成像测量的计算机上安装和更新，因此，开源成像系统是部署的限制因素，需要增加IT桌面支持和维护。通过将图像分析功能调整到基于网络的开源平台，将有助于和促进该系统在每个进行成像的地点的应用。中立、开源、可扩展、零占用空间的 Web 查看器和用于显示和分析 DICOM 图像的支持服务器，以及 2) 创建一个插件架构，使我们能够用这个零占用空间的 Web 查看器替换当前的开源图像工作站。 TIMC 临床试验管理系统为了使该系统广泛适用于肿瘤学研究界，除了开发 TIMC Web 应用程序的接口之外，我们还将实现 AIM（注释和图像标记）接口，以便caBIG 研究人员和其他 AIM 框架研究项目可以轻松地与我们的网络查看器集成，该查看器将满足特定于肿瘤学临床试验需求的放射学肿瘤测量的所有基本要求，同时也足够灵活，可以为用户进行配置。首选项并通过插件进行扩展，以支持各种研究工作流程作为共享研究资源。为了实现这些设计目标，查看器及其所有功能将仅通过 Web 浏览器交付到客户端计算机，而无需在客户端计算机上安装任何内容。移动设备，这大大简化了并降低了软件部署的成本和支持要求，并提高了可访问性，使研究人员、成像软件开发人员、负责人和患者能够在免费且可公开扩展的环境中访问肿瘤临床试验图像。网络 DICOM 查看器将与 TIMC 临床试验信息学管理系统完全集成，以便在完全基于网络的情况下在 NCI 癌症中心进行部署。桌面IT还将提供 AIM 界面，以便网络查看器可以广泛集成到 caBIG/AIM 癌症研究社区。