Technology Core

技术核心

• 批准号: 10715742
• 负责人: Rebecca R. Richards-Kortum
• 金额: $ 67.65万
• 依托单位: RICE UNIVERSITY
• 依托单位国家: 美国
• 财政年份: 2023
• 资助国家: 美国
• 起止时间: 2023-09-13 至 2028-07-31
• 项目状态: 未结题
• 来源: https://reporter.nih.gov/project-details/10715742
• 关键词: Acceleration; Address; Adoption; Artificial Intelligence; Biological Assay; Biomedical Engineering; Brazil; COVID testing; COVID-19 test; Caring; Clinical; Collaborations; Collection; Computers; Consensus; Decentralization; Development; Diagnostic; Disease; Early Diagnosis; Engineering; Equity; Evaluation; Funding; Generations; Goals; Growth; Health Technology; Health trends; Healthcare; Image; Image Analysis; Imaging Device; Imaging technology; Infrastructure; Instruction; Intervention; Link; Machine Learning; Marketing; Mediation; Medical center; Mentorship; Mission; Molecular; Monitor; Performance; Point of Care Technology; Publishing; RADx; Research Personnel; Resource-limited setting; Resources; Rice; Screening for cancer; Services; Shapes; Specific qualifier value; System; Technology; Test Result; Testing; Texas; Translating; Translations; Underserved Population; Universities; Validation; Work; algorithm development; cancer care; cancer health disparity; clinically relevant; commercial prototype; commercialization; design; diagnostic technologies; experience; fabrication; global health; home test; improved; innovation; laboratory equipment; low and middle-income countries; manufacturability; manufacture; mobile computing; molecular diagnostics; pandemic disease; point of care; point of care testing; point-of-care diagnostics; prototype; recruit; research clinical testing; response; rural setting; screening; self testing; sensor; success; technology platform; underserved community; usability

Abstract: The global market for point‐of‐care (POC) tests is projected to grow 12% annually, exceeding US$90B by 2030. Drivers of market growth include emerging disease threats, increasing demand for self‐testing, successful market shaping interventions, increasing demand for essential diagnostics in low‐ and middle‐income countries (LMICs), and a trend for health‐care decentralization. More than a billion COVID‐19 tests are now performed annually at the POC, and the pandemic testing response demonstrated that: a new generation of high performance, affordable molecular tests can be manufactured, distributed, and rapidly adapted for new targets; a broad segment of users can accurately perform home testing; and test results can enable rapid treatment when needed. The POCTRN network contributed significantly to these successes. Despite the success of RADx and the rapid scale of POC testing for COVID, a number of significant barriers still remain to achieve the potential of POC testing, especially for the early detection of cancer. The mission of The Technology Core of The Center for Innovation and Translation of Point‐of‐Care Technologies for Equitable Cancer Care (CITEC) is to join POCTRN in supporting and accelerating the development and translation of high priority POC technologies specifically designed for cancer screening and early detection for under‐served populations. The first aim of the Technology Core (TC) is to identify and support new meritorious projects to develop POC technologies for cancer screening or early cancer detection from prototype through early clinical testing. In collaboration with the Dissemination Core, the TC will conduct assessments to identify high priority unmet clinical needs for cancer screening and early detection, and, subsequently, publish consensus POC Technology Needs Statements. CITEC will issue targeted solicitations offering funding to address these needs. The TC will support technology projects specifically designed for underserved communities, including those designed to address challenges and barriers associated with cancer health disparities and low‐resource settings (e.g., rural settings, settings with limited infrastructure). The second aim of the TC is to assist supported POC technology developers to refine their clinical needs statement, including target test specifications, and refine and assess technical performance, usability, and manufacturability of their technology, with the objective of accelerating the path to translation and clinical adoption. The TC will create a CITEC Core Technology Laboratory with unique and comprehensive technical resources to support the design, fabrication and rapid optimization of POC imaging technologies, POC molecular sensors, and machine learning based image analysis strategies appropriate for mobile platforms. The third aim of the TC is to help translate promising prototypes to clinical validation and commercialization. The TC will work closely with the Clinical Core to identify technologies ready for clinical evaluation and to support the transition to evaluation in relevant clinical settings. The TC will work with POC test developers to accelerate efforts to develop commercial prototypes and to develop successful commercialization strategies, leveraging resources in the Texas Medical Center and in Brazil. Through these aims, the TC will work with other CITEC cores to build and support a robust pipeline of POC technologies for equitable cancer screening and early detection.

抽象的： 全球护理点（POC）测试的市场预计每年增长12％，到2030年超过90B美元。 市场增长包括新兴疾病威胁，增加自我测试的需求，成功的市场塑造 干预措施，低收入国家（LMIC）对基本诊断的需求增加，以及一种趋势 健康方面的权力下放。现在，每年在POC上进行超过十亿的共同19测试，并且 大流行测试反应表明：新一代高性能，负担得起的分子测试可以是 制造，分布和快速适应新目标；大量的用户可以准确地执行家园 测试；并且测试结果可以在需要时快速治疗。 Poctrn网络对这些网络做出了重大贡献 成功。尽管RADX取得了成功和COVID的POC测试的快速规模，但仍有许多重要的障碍 保持POC测试的潜力，尤其是为了早期检测到癌症的潜力。技术的使命 公平癌症护理（CETEC）的创新和翻译中心的核心是 加入POCTRN，以支持和加速高优先级POC技术的开发和翻译 专为癌症筛查和时间不足的人群的早期检测而设计。技术核心的第一个目的（TC） 是识别和支持新的有功项目，以开发用于癌症筛查或早期癌症的POC技术 从原型检测到早期临床测试。与传播核心合作，TC将进行 评估以确定高优先级未满足癌症筛查和早期检测的临床需求，随后， 发布共识POC技术需要声明。 CETEC将发出针对性的招标，提供资金来解决 这些需求。 TC将支持专门为服务不足的社区设计的技术项目，包括 旨在应对与癌症健康分布和低资源环境相关的挑战和障碍（例如 设置，基础架构有限的设置）。 TC的第二个目的是协助支持的POC技术开发人员 为了完善其临床需求声明，包括目标测试规格，并完善和评估技术绩效， 其技术的可用性和制造，目的是加速翻译和临床的道路 采用。 TC将创建一个具有独特而全面的技术资源的Citec Core Technology实验室 支持POC成像技术，POC分子传感器和机器的设计，制造和快速优化 基于学习的图像分析策略适合移动平台。 TC的第三个目标是帮助翻译 有希望的临床验证和商业化原型。 TC将与临床核心紧密合作以识别 准备临床评估并支持相关临床环境中评估的技术。 TC 将与POC测试开发人员合作，以加速开发商业原型并开发成功的努力 商业化策略，利用德克萨斯州医疗中心和巴西的资源。通过这些目标，TC 将与其他Citec核心合作，建造和支持强大的POC技术管道，以进行公平的癌症筛查 和早期检测。