VISUAL SYSTEM ORGANIZATION AND DEVELOPMENT

视觉系统的组织和开发

• 批准号: 2391641
• 负责人: Vivien A Casagrande
• 金额: $ 27.86万
• 依托单位: VANDERBILT UNIVERSITY
• 依托单位国家: 美国
• 财政年份: 1978
• 资助国家: 美国
• 起止时间: 1978-02-01 至 1998-03-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/2391641
• 关键词: brain electrical activity; cytochromes; electrophysiology; experimental brain lesion; histology; lateral geniculate body; neural information processing; neuroanatomy; neuronal transport; single cell analysis; visual cortex; visual deprivation; visual pathways; visual perception

A revised model of visual information processing has begun to emerge from our primate studies on the structure and function of the three segregated, parallel pathways (magnocellular (M), parvocellular (P), and koniocellular (K)) from the lateral geniculate nucleus (LGN) to striate cortex. The parallel inputs are utilized by the laminar and compartmental (i.e., cytochrome oxidase (CO) blob and interblob) circuitry of striate cortex to produce new output pathways appropriate for the next steps of analysis. Just as LGN layers appear to be arranged to optimally distribute information to striate, the interactions within striate cortex may create (or re-encode) visual signals to optimally support the functional requirements of the different extrastriate visual areas. In fight of this model, our project's broad aim is to identify the key components of parallel pathways beginning at the LGN, and to understand how these pathways are transformed within the layers and compartments of primate striate cortex to produce the parallel output pathways. The specific aims are designed to test hypotheses generated by our model of parallel visual cortical organization. In Aim I, we will morphologically characterize the classes of LGN cells that project to the CO rich blob, and CO poor interblob zones of the primate striate cortex. In Aim II, we will investigate the relative contributions of LGN pathways to the physiological properties of CO blob and interblob cells. In Aim III, we will elucidate the functional significance of anatomical and physiological differences between striate cortical compartments and layers. The results of our proposed studies will contribute important new information on the fundamental understanding of how the brain processes visual information.

经过修订的视觉信息处理模型已开始从 我们关于三个的结构和功能的灵长类动物研究 隔离的平行途径（大细胞（M），副细胞（P）和 从侧向基因核（LGN）到分段的koniocelular（k）） 皮质。 平行输入由层流和 隔室（即细胞色素氧化酶（CO）BLOB和INTERBLOB） 条纹皮层的电路以产生适当的新输出途径 为了下一步分析。 正如LGN层似乎布置的一样 为了最佳分发信息以进行条纹， 条纹皮质可以创建（或重新编码）视觉信号以最佳 支持不同的外室视觉室的功能要求 区域。 在该模型的战斗中，我们项目的广泛目的是确定关键 平行途径的组件从LGN开始，并了解 这些途径如何在层和隔室中转换 灵长类动物条纹皮质产生并行输出途径。 这 具体目的旨在测试我们的模型产生的假设 平行视觉皮质组织。 在目标I中，我们将在形态上表征LGN细胞的类别 该项目向Co Rich Blob和Co的较差的Interblob区域 灵长类运动皮层。 在AIM II中，我们将调查亲戚 LGN途径对CO BLOB生理特性的贡献 和Interblob细胞。 在AIM III中，我们将阐明功能 分裂和生理差异的意义 皮质隔室和层。 我们提出的研究的结果将为重要的新作用 有关大脑如何处理的基本了解的信息 视觉信息。