OPTICAL IMAGING SYSTEM

光学成像系统

• 批准号: 2803517
• 负责人: Vivien A Casagrande
• 金额: $ 16.95万
• 依托单位: VANDERBILT UNIVERSITY
• 依托单位国家: 美国
• 财政年份: 1999
• 资助国家: 美国
• 起止时间: 1999-04-01 至 2001-09-30
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/2803517
• 关键词: bioimaging /biomedical imaging; biomedical equipment; biomedical equipment purchase; brain imaging /visualization /scanning; cerebral cortex; functional magnetic resonance imaging; neurosciences

This NCRR shared instrumentation grant application requests funds for an optical imaging system. This system is designed to directly visualize neural activity in relation to different stimulus conditions. Signals are imaged from the cortical surface of awake or lightly anesthetized animals. The method relies on the discrimination of changes in intrinsic signals which correlate with levels of neural activity. The intrinsic signals that are imaged have been proposed to arise, in part, from local changes in the ratio of oxy- to deoxyhemoglobin that are known to accompany changes in neural activity. This powerful method has been used successfully to determine not only how maps of different stimulus properties are arranged relative to one another, but also how maps develop or change over time under different manipulation conditions. This method is also compatible with a variety of other tools such as standard single unit recording and many anatomic techniques. In this proposal, a group of six investigators will share the optical imaging system. All of these investigators work well together and have funded projects that will greatly benefit from the new technology provided by optical imaging. Seven projects are described of which six are proposed as part of funded projects or are appropriate to one or more aims of this funded research. The other project represents an example of new directions that will enhance the research of several investigators and provide new opportunities for collaboration with the group. The equipment will be housed in the Department of Psychology within research space contiguous to animal quarters. Mechanisms are in place to provide administrative support to monitor and manage the day-to-day and long-term user of the optical imaging system, as well as to support others at Vanderbilt or nearby institutions interested in using this system for their research. The optical imaging initiative will provide an ideal interface between wet-lab and clinical neuroscience and the new fMRI initiatives at Vanderbilt. In summary, this shared system would greatly enhance on-going research and provide opportunities for exciting new directions for the Vanderbilt Neuroscience community.

此NCRR共享的仪器赠款应用程序要求为光学成像系统提供资金。该系统旨在直接可视化与不同刺激条件相关的神经活动。信号是从清醒或轻度麻醉动物的皮质表面成像的。该方法依赖于歧视与神经活动水平相关的内在信号变化。已经提出成像的固有信号部分是由于已知伴随神经活性变化的氧和脱氧血红蛋白比的局部变化。这种强大的方法已成功地用于确定如何相对于彼此的不同刺激属性的地图如何布置，而且还确定了在不同的操纵条件下如何随着时间的推移而变化或变化。该方法还与各种其他工具（例如标准的单个单元记录和许多解剖技术）兼容。在此提案中，六个研究人员将共享光学成像系统。所有这些研究人员合作良好，并为项目提供了资金，这些项目将从光学成像提供的新技术中受益匪浅。描述了七个项目，其中六个是作为资助项目的一部分提出的，或适合这项资助研究的一个或多个目标。另一个项目代表了新方向的一个示例，将增强几个研究人员的研究，并提供与小组合作的新机会。该设备将安置在心理学系与动物区域相邻的研究空间中。建立了机制，可以提供行政支持，以监视和管理光学成像系统的日常和长期用户，并在范德比尔特或附近的机构中为有兴趣使用该系统进行研究的机构提供支持。光学成像计划将在湿角和临床神经科学与范德比尔特的新fMRI计划之间提供理想的接口。总而言之，该共享系统将极大地增强正在进行的研究，并为范德比尔特神经科学社区的新方向提供机会。