Scripps Clinical and Translational Science Hub

斯克里普斯临床和转化科学中心

• 批准号: 10621679
• 负责人: Eric Jeffrey Topol
• 金额: $ 602.98万
• 依托单位: SCRIPPS RESEARCH INSTITUTE, THE
• 依托单位国家: 美国
• 财政年份: 2023
• 资助国家: 美国
• 起止时间: 2023-05-01 至 2030-04-30
• 项目状态: 未结题
• 来源: https://reporter.nih.gov/project-details/10621679
• 关键词: 2019-nCoV; Acceleration; Address; Area; Artificial Intelligence; Awareness; Biosensor; California; Child; Clinical Research; Clinical Sciences; Clinical Trials; Collaborations; Communities; Country; County; Data; Data Aggregation; Data Set; Dedications; Democracy; Diagnostic; Dimensions; Dissemination and Implementation; Diverse Workforce; Drug Screening; Ecosystem; Education; Elements; Ethics; Ethnic Origin; Fostering; Foundations; Genomic medicine; Genomics; Geography; Goals; Health; Healthcare; Heart Rate; Human; Human Resources; Industry Collaboration; Informatics; Institute of Medicine (U.S.); Institution; Intervention; Longevity; Medical; Medical Research; Methodology; Modeling; Outcome; Patients; Physiological; Population; Post-Acute Sequelae of SARS-CoV-2 Infection; Preventive; Process; Productivity; Program Development; Public Health; Public Health Informatics; Race; Research; Research Institute; Research Project Grants; Resource Informatics; Resources; Rest; SARS-CoV-2 infection; Sampling; Science; Services; Site; Sleep Disorders; Structure; Techniques; Time; Training; Translational Research; Universities; Vision; Voice; biomedical informatics; career development; community engaged research; community engagement; computer science; computerized data processing; cost effective; data standards; digital; digital medicine; digital models; digital platform; digital twin; diversity and inclusion; drug repurposing; educational atmosphere; empowerment; equity, diversity, and inclusion; ethnic diversity; health data; health equity; health inequalities; improved; individualized medicine; innovation; interoperability; multimodal data; multimodality; pandemic disease; pregnancy disorder; programs; public health emergency; racial diversity; real time model; response; secondary analysis; sensor; socioeconomics; tool; translational approach

PROJECT SUMMARY / ABSTRACT The Scripps Research Translational Institute (SRTI) is the foundation for the Scripps hub and is dedicated to accelerating science that will improve human health. SRTI’s emphasis on genomics, digital medicine, and informatics/analytics fosters a multi-dimensional understanding of individualized human health. The Scripps hub has previously included the Scripps Research Institute (SR) and Scripps Health (SH) as principal partners, including Rady Children’s Institute of Genomic Medicine (RCIGM) for genomic medicine initiatives and California Institute for Medical Research (Calibr) for drug repurposing / discovery. In the new CTSA cycle, our partners have expanded to include San Diego State University (SDSU), enabling us to combine forces in computer science, artificial intelligence, biosensors, and diversity inclusion and equity initatives. SRTI’s expertise in genomics was highlighted during the pandemic. We became one of the country’s most productive sequencing centers for SARS-CoV-2 by rapidly forming the “SEARCH” alliance to process samples with the San Diego County Department of Health, UCSD, Sharp Health, California Department of Public Health, Helix, and our partners RCIGM and SH. Digital medicine has been one of SRTI’s core strengths, having pioneered the first remote, site-less digital clinical trial and now expanding this methodology to address many other medical conditions such as health during pregnancy and sleep disorders. Our Digital Trials Center launched the Digital Engagement & Tracking for Early Control and Treatment Scripps (DETECT) study, and in a matter of weeks our team was able to accurately predict the likelihood of Covid with SARS-CoV-2 using passively collected resting heart rate data from wristband sensors and later to identify a physiologic signature that correlates with Long Covid (Post-Acute Sequelae or SARS-CoV-2 Infection). The Scripps hub will innovate clinical and translational science to improve human health across the lifespan and diverse racial, ethnic, geographic and socioeconomic communities. The hub will provide a nurturing environment for education, training, and career development with a focus on individualized health domains of genomics, digital medicine, and biomedical informatics, to empower tomorrow’s diverse workforce.

项目概要/摘要 斯克里普斯研究转化研究所 (SRTI) 是斯克里普斯中心的基础，致力于 加速科学发展，改善人类健康。SRTI 重点关注基因组学、数字医学和 信息学/分析促进了对个体人类健康的多维理解。 此前已将斯克里普斯研究所 (SR) 和斯克里普斯健康中心 (SH) 作为主要合作伙伴， 包括拉迪儿童基因组医学研究所 (RCIGM) 的基因组医学计划和加利福尼亚州 医学研究所 (Calibr) 致力于药物再利用/发现 在新的 CTSA 周期中，我们的合作伙伴。 已扩展到包括圣地亚哥州立大学 (SDSU)，使我们能够在计算机领域联合力量 科学、人工智能、生物传感器以及多样性包容和公平倡议。 SRTI 在基因组学方面的专业知识在疫情期间得到了凸显，我们成为了全国最专业的机构之一。 通过快速组建“SEARCH”联盟来处理样本，建立高效的 SARS-CoV-2 测序中心 与圣地亚哥县卫生部、加州大学圣地亚哥分校、Sharp Health、加州公共卫生部、 Helix 以及我们的合作伙伴 RCIGM 和 SH。 数字医学一直是 SRTI 的核心优势之一，它率先推出了第一个远程、无站点数字临床 试验，现在将这种方法扩展到解决许多其他医疗状况，例如期间的健康状况 我们的数字试验中心推出了早期数字参与和跟踪。 控制和治疗斯克里普斯 (DETECT) 研究，我们的团队在几周内就能够准确地 使用从腕带被动收集的静息心率数据预测 Covid 与 SARS-CoV-2 的可能性 传感器，然后识别与长期新冠病毒相关的生理特征（急性后遗症或 SARS-CoV-2 感染）。 斯克里普斯中心将创新临床和转化科学，以改善人类整个生命周期的健康 该中心将提供一个多元化的种族、民族、地理和社会经济社区。 用于教育、培训和职业发展，重点关注基因组学、数字化的个性化健康领域 医学和生物医学信息学，为未来的多元化劳动力提供支持。