Scripps Clinical and Translational Science Hub

斯克里普斯临床和转化科学中心

• 批准号: 10621679
• 负责人: Eric Jeffrey Topol
• 金额: $ 602.98万
• 依托单位: SCRIPPS RESEARCH INSTITUTE, THE
• 依托单位国家: 美国
• 财政年份: 2023
• 资助国家: 美国
• 起止时间: 2023-05-01 至 2030-04-30
• 项目状态: 未结题
• 来源: https://reporter.nih.gov/project-details/10621679
• 关键词: 2019-nCoV; Acceleration; Address; Area; Artificial Intelligence; Awareness; Biosensor; California; Child; Clinical Research; Clinical Sciences; Clinical Trials; Collaborations; Communities; Country; County; Data; Data Aggregation; Data Set; Dedications; Democracy; Diagnostic; Dimensions; Dissemination and Implementation; Diverse Workforce; Drug Screening; Ecosystem; Education; Elements; Ethics; Ethnic Origin; Fostering; Foundations; Genomic medicine; Genomics; Geography; Goals; Health; Healthcare; Heart Rate; Human; Human Resources; Industry Collaboration; Informatics; Institute of Medicine (U.S.); Institution; Intervention; Longevity; Medical; Medical Research; Methodology; Modeling; Outcome; Patients; Physiological; Population; Post-Acute Sequelae of SARS-CoV-2 Infection; Preventive; Process; Productivity; Program Development; Public Health; Public Health Informatics; Race; Research; Research Institute; Research Project Grants; Resource Informatics; Resources; Rest; SARS-CoV-2 infection; Sampling; Science; Services; Site; Sleep Disorders; Structure; Techniques; Time; Training; Translational Research; Universities; Vision; Voice; biomedical informatics; career development; community engaged research; community engagement; computer science; computerized data processing; cost effective; data standards; digital; digital medicine; digital models; digital platform; digital twin; diversity and inclusion; drug repurposing; educational atmosphere; empowerment; equity, diversity, and inclusion; ethnic diversity; health data; health equity; health inequalities; improved; individualized medicine; innovation; interoperability; multimodal data; multimodality; pandemic disease; pregnancy disorder; programs; public health emergency; racial diversity; real time model; response; secondary analysis; sensor; socioeconomics; tool; translational approach

PROJECT SUMMARY / ABSTRACT The Scripps Research Translational Institute (SRTI) is the foundation for the Scripps hub and is dedicated to accelerating science that will improve human health. SRTI’s emphasis on genomics, digital medicine, and informatics/analytics fosters a multi-dimensional understanding of individualized human health. The Scripps hub has previously included the Scripps Research Institute (SR) and Scripps Health (SH) as principal partners, including Rady Children’s Institute of Genomic Medicine (RCIGM) for genomic medicine initiatives and California Institute for Medical Research (Calibr) for drug repurposing / discovery. In the new CTSA cycle, our partners have expanded to include San Diego State University (SDSU), enabling us to combine forces in computer science, artificial intelligence, biosensors, and diversity inclusion and equity initatives. SRTI’s expertise in genomics was highlighted during the pandemic. We became one of the country’s most productive sequencing centers for SARS-CoV-2 by rapidly forming the “SEARCH” alliance to process samples with the San Diego County Department of Health, UCSD, Sharp Health, California Department of Public Health, Helix, and our partners RCIGM and SH. Digital medicine has been one of SRTI’s core strengths, having pioneered the first remote, site-less digital clinical trial and now expanding this methodology to address many other medical conditions such as health during pregnancy and sleep disorders. Our Digital Trials Center launched the Digital Engagement & Tracking for Early Control and Treatment Scripps (DETECT) study, and in a matter of weeks our team was able to accurately predict the likelihood of Covid with SARS-CoV-2 using passively collected resting heart rate data from wristband sensors and later to identify a physiologic signature that correlates with Long Covid (Post-Acute Sequelae or SARS-CoV-2 Infection). The Scripps hub will innovate clinical and translational science to improve human health across the lifespan and diverse racial, ethnic, geographic and socioeconomic communities. The hub will provide a nurturing environment for education, training, and career development with a focus on individualized health domains of genomics, digital medicine, and biomedical informatics, to empower tomorrow’s diverse workforce.

项目摘要 /摘要 Scripps研究转化学院（SRTI）是Scripps Hub的基础，致力于 加速科学将改善人类健康。 SRTI强调基因组学，数字医学和 信息/分析促进了对个性化人类健康的多维理解。 Scripps集线器 以前曾将Scripps研究所（SR）和Scripps Health（SH）作为主要合作伙伴， 包括基因组医学计划和加利福尼亚州的Rady儿童基因组医学研究所（RCIGM） 医学研究所（校准）用于药物重新利用 /发现。在新的CTSA周期中，我们的合作伙伴 已经扩展到包括圣地亚哥州立大学（SDSU），使我们能够在计算机中结合部队 科学，人工智能，生物传感器以及多样性包容和公平的初始化。 大流行期间，SRTI在基因组学方面的专业知识得到了强调。我们成为该国最大的 通过快速形成“搜索”联盟来处理样品，用于SARS-COV-2的生产测序中心 与圣地亚哥县卫生部，UCSD，加利福尼亚州公共卫生部夏普健康部， Helix，以及我们的合作伙伴Rcigm and Sh。 数字医学一直是SRTI的核心优势之一，他开创了第一个遥远，无网站的数字临床 试验并现在扩展这种方法，以解决许多其他医疗状况，例如健康状况 怀孕和睡眠障碍。我们的数字试验中心推出了早期的数字参与和跟踪 对照和治疗scripps（检测）研究，在几周的时间内，我们的团队能够准确 使用从腕带中被动收集的静息心率数据预测与SARS-COV-2共证的可能性 传感器和后来确定与长期相关的生理特征（急性后遗症或 SARS-COV-2感染）。 Scripps Hub将创新临床和转化科学，以改善整个生命周期的人类健康和 潜水员种族，种族，地理和社会经济社区。枢纽将提供一个养育环境 用于教育，培训和职业发展，重点是基因组学的个性化健康领域 医学和生物医学信息，以增强明天的潜水员劳动力。