Scripps Translational Science Institute

斯克里普斯转化科学研究所

• 批准号: 10159148
• 负责人: Eric Jeffrey Topol
• 金额: $ 18.27万
• 依托单位: SCRIPPS RESEARCH INSTITUTE, THE
• 依托单位国家: 美国
• 财政年份: 2018
• 资助国家: 美国
• 起止时间: 2018-05-01 至 2023-04-30
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/10159148
• 关键词: Autopsy; Award; Bachelor' s Degree; Big Data Methods; Bioinformatics; Biological Sciences; California; Child; Childhood; Clinical Trials; Collaborations; Communities; Complement; County; Development; Disease; Enrollment; Flowers; Future; Genomic medicine; Genomics; Goals; Grant; Growth; Health; Individual; Infrastructure; Institutes; Longevity; Medical Research; Medicine; Molecular; Parents; Participant; Pathogen detection; Pharmaceutical Preparations; Population; Precision Medicine Initiative; Quality Control; Research; Research Institute; Technology; Training; Translational Research; Underrepresented Minority; United States National Institutes of Health; clinical care; cohort; college; digital; fitbit; handheld mobile device; healthy aging; human genomics; improved; individualized medicine; industry partner; innovation; mobile application; precision medicine; programs; quality assurance; sensor; supercomputer; undergraduate student

Overall Abstract The Scripps Translational Science Institute (STSI) is the center of the Scripps Hub, formed in 2007, dedicated to accelerating individualized medicine, improving medical research and clinical care, and training the future leaders of the biomedical workforce. The Scripps hub has included The Scripps Research Institute (TSRI) and Scripps Health (SH) as its principal components, along with the San Diego Supercomputer Center for its bioinformatic initiatives. In the new CTSA cycle, our partners have expanded to now include the California Institute for Medical Research (Calibr), recently made a Scripps Research Institute, and the Rady Children's Institute of Genomic Medicine (RCIGM). These 2 new partners will markedly increase our efforts for drug repurposing/ discovery and across the lifespan to the pediatric population. Digital medicine has been one of STSI's core strengths, with innovations to digitize clinical trials from end-to-end (enrollment to dissemination). Our focus on human genomics has been critical to building infrastructure at the hub, supporting many studies throughout the San Diego region including healthy aging (Wellderly), unknown diseases, molecular autopsy and rapid pathogen detection through sequencing. We received support from the CTSA Trial Innovation Network (TIN) for 2 of these projects. Recent STSI-supported projects feature a fusion of both genomics and digital medicine for mobile app development and clinical trials. An important affirmation of STSI's progress and contributions was its selection in 2016 by the NIH to be The Participant Center for the Precision Medicine Initiative (PMI) All of Us cohort. Many other aspects of the Scripps hub are undergoing remarkable growth. Our life science industry partners, which has been an essential STSI strategy, has expanded with more than 20 new collaborations over the past CTSA cycle. A few of these have led to exclusive big data analytic programs, cumulatively, with Walgreens, Withings, and Fitbit, involving tens of millions of individuals using mobile device sensors. Community engagement research at the Scripps hub has blossomed with 3 new R01 grants that build on our track record of working with underrepresented minorities in San Diego County and expertise in digital medicine technology. Our inter-hub collaborations and active participation in the CTSA Consortium have markedly increased, as have our educational and training initiatives. We have developed new initiatives to further enhance workforce diversity and entrepreneurial training. These efforts are newly complemented by the Scripps Research Biosciences College that will begin enrolling undergraduate students for a baccalaureate degree next year.

全面的 抽象的 斯克里普斯转化科学研究所 (STSI) 是斯克里普斯中心的中心，成立于 2007 年，致力于 加速个体化医疗，改善医学研究和临床护理，培养未来 生物医学队伍的领导者。斯克里普斯中心包括斯克里普斯研究所 (TSRI) 和 斯克里普斯健康中心 (SH) 作为其主要组成部分，以及圣地亚哥超级计算机中心作为其主要组成部分 生物信息倡议。在新的 CTSA 周期中，我们的合作伙伴现已扩大到包括加州 医学研究所 (Calibr) 最近成立了斯克里普斯研究所，以及拉迪儿童医院 基因组医学研究所（RCIGM）。这两个新的合作伙伴将显着加大我们在药物方面的努力 重新利用/发现并贯穿儿科人群的生命周期。数字医学已成为其中之一 STSI 的核心优势在于通过创新实现从端到端（招募到传播）的临床试验数字化。 我们对人类基因组学的关注对于在中心建设基础设施、支持许多研究至关重要 整个圣地亚哥地区，包括健康老龄化（Wellderly）、未知疾病、分子尸检 通过测序进行快速病原体检测。我们得到了 CTSA 试验创新网络的支持 其中 2 个项目的 (TIN)。最近 STSI 支持的项目融合了基因组学和数字技术 用于移动应用程序开发和临床试验的医学。对STSI进步的重要肯定 其贡献在于 2016 年被 NIH 选为精准医学参与中心 倡议（PMI）“我们所有人”队列。 斯克里普斯中心的许多其他方面正在经历显着的增长。我们的生命科学行业合作伙伴， 这是一项重要的 STSI 战略，过去已扩大了 20 多项新合作 CTSA 循环。其中一些已经导致与沃尔格林（Walgreens）累积的独家大数据分析计划， Withings 和 Fitbit，涉及数千万使用移动设备传感器的个人。社区 斯克里普斯中心的参与研究蓬勃发展，在我们的往绩记录的基础上获得了 3 项新的 R01 资助 与圣地亚哥县代表性不足的少数族裔合作以及数字医学技术方面的专业知识。 我们的中心间合作以及对 CTSA 联盟的积极参与显着增加， 我们的教育和培训举措。我们制定了新举措以进一步增强劳动力 多样性和创业培训。斯克里普斯研究中心对这些努力进行了新的补充 生物科学学院将于明年开始招收本科生攻读学士学位。