Technology to Empower Changes in Health (TECH) Network Participant Technologies Center

技术赋能健康变革 (TECH) 网络参与者技术中心

• 批准号: 10684957
• 负责人: Eric Jeffrey Topol
• 金额: $ 1560.18万
• 依托单位: SCRIPPS RESEARCH INSTITUTE, THE
• 依托单位国家: 美国
• 财政年份: 2016
• 资助国家: 美国
• 起止时间: 2016-07-06 至 2023-06-30
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/10684957
• 关键词: Accelerometer; Address; Age; American; Android; Apple; Back; Blue Cross; Blue Shield; Cellular Phone; Climacteric; Communication; Computer software; Consent; Data; Data Analyses; Data Collection; Development; Devices; Ecosystem; Enrollment; Ensure; Foundations; Future; Goals; Growth; Health; Infrastructure; Institutes; International; Internet; Knowledge; Language; Lead; Life; Longitudinal cohort; Maintenance; Medical; Methods; PMI cohort; Participant; Patients; Persons; Population Heterogeneity; Privacy; Provider; Research; Research Personnel; Resources; Safety; Secure; Security; Stream; System; Technology; Telephone; Testing; Time; Translational Research; Vendor; Vision; Work; data acquisition; data communication; data management; design; digital; empowered; experience; flexibility; health care delivery; improved; innovation; lens; mHealth; member; microphone; mobile application; patient engagement; peer; programs; sensor; support network; usability; web services; wireless

Abstract/Project Summary Remarkable advancements in our nation's digital infrastructure combined with explosive growth in pervasive wireless connectivity have created the unprecedented potential to improve both our health and the delivery of healthcare. Beyond their universal availability, smartphones and the mobile networks that support them offer an unparalleled platform for health-related data acquisition and communications. The visionary Precision Medicine Initiative Cohort Program (PMI-CP) is possible, in large part, due to the availability of this digital infrastructure. However, to convert the enormous pool of mostly disjointed information available through a million-person longitudinal cohort into meaningful, life-changing medical knowledge requires development of an innovative, member-centric, engaging, and secure digital network that is state-of-art today, and by design, sustainably so over ensuing years and decades. In order to assure that the PMI-CP achieves its goal to transform the existing culture of medical practice and research by empowering patients, researchers and providers to work together as peers requires the collaborative support of many people with diverse expertise but a singular focus on participant-centeredness. The Participant Technologies Center (PTC) is a critical component to making that happen, and to ensure that we are able to successfully meet the needs of the PMI Steering Committee, and most importantly, the PMI participants, we have formed a network or world-class partners that together have the resources, experience and capabilities necessary to expertly address the known and not-yet known challenges of an endeavor as transformational and far-sighted as the PMI-CP. The Technology to Empower Change in Health (TECH) network is led by Scripps Translational Science Institute and Sage Bionetworks, and includes PatientsLikeMe, Qualcomm, Walgreens, Verizon, Lockheed-Martin, and the Blue Cross Blue Shield Association, bringing together unprecedented experience and knowledge around participant engagement, digital security and personal technologies. Although the PTC is designed to optimize the utilization of technologies in the PMI-CP, our unwavering focus will be on the PMI participant and how to maximize the benefit of participation for them personally. We will accomplish this by laying a foundation built upon personalized engagement strategies, an resolute commitment to security and privacy, and assuring the availability of the state-of-the-art technology needed to meet all current and future data and information sharing needs. .

摘要/项目摘要 我们国家数字基础设施的显着进步与爆炸性增长相结合 在无线的无线连接中，创造了前所未有的潜力来改善我们的 健康与医疗保健的提供。除了它们的通用可用性，智能手机和 支持它们的移动网络为健康相关数据提供了无与伦比的平台 收购和通讯。有远见的精密医学倡议队列计划 （PMI-CP）在很大程度上是由于该数字基础架构的可用性。然而， 转换一百万个人可用的大部分脱节信息的巨大池 纵向人群变成有意义的，改变生活的医学知识需要发展 当今最先进的创新，以会员为中心，引人入胜且安全的数字网络， 而且，通过设计，在随后几年和几十年中可持续地如此。 为了确保PMI-CP实现了改变现有医学文化的目标 通过赋予患者，研究人员和提供者能力的实践和研究 同龄人需要许多具有多样专业知识但单数的人的协作支持 专注于以参与者为中心。参与者技术中心（PTC）是关键 实现这一目标的组成部分，并确保我们能够成功满足 PMI指导委员会的需求，最重要的是PMI参与者，我们有 组成一个网络或世界一流的合作伙伴，共同拥有资源，经验和 熟练应对已知且尚未知道的挑战所需的能力 作为变革型和远视的努力，如PMI-CP。授权的技术 健康（技术）网络的变化由Scripps转化科学学院和Sage领导 Bionetworks，包括患者，Qualcomm，Walgreens，Verizon，Lockheed-Martin， 和蓝十字蓝盾协会，汇集了前所未有的经验和 有关参与者参与，数字安全和个人技术的知识。 尽管PTC旨在优化PMI-CP中技术的利用，但我们 坚定不移的重点将放在PMI参与者上，以及如何最大化参与的好处 对他们个人。我们将通过建立在个性化的基础来实现这一目标 参与策略，坚决对安全和隐私的承诺，并确保 满足所有当前和未来数据所需的最新技术以及 信息共享需求。 。

项目成果

Racial Disparities in Barriers to Care for Patients With Diabetic Retinopathy in a Nationwide Cohort.

• DOI: 10.1167/tvst.12.3.14
• 发表时间: 2023-03-01
• 期刊: TRANSLATIONAL VISION SCIENCE & TECHNOLOGY
• 影响因子: 3
• 作者: Huang, Bonnie B.;Saseendrakumar, Bharanidharan Radha;Delavar, Arash;Baxter, Sally L.
• 通讯作者: Baxter, Sally L.

Integrating gene expression and clinical data to identify drug repurposing candidates for hyperlipidemia and hypertension.

• DOI: 10.1038/s41467-021-27751-1
• 发表时间: 2022-01-10
• 期刊: Nature communications
• 影响因子: 16.6
• 作者: Wu P;Feng Q;Kerchberger VE;Nelson SD;Chen Q;Li B;Edwards TL;Cox NJ;Phillips EJ;Stein CM;Roden DM;Denny JC;Wei WQ
• 通讯作者: Wei WQ

Implementing a universal informed consent process for the All of Us Research Program.

为“我们所有人研究计划”实施普遍知情同意流程。

• 发表时间: 2019
• 期刊: Pacific Symposium on Biocomputing. Pacific Symposium on Biocomputing
• 作者: Doerr,Megan;Grayson,Shira;Moore,Sarah;Suver,Christine;Wilbanks,John;Wagner,Jennifer
• 通讯作者: Wagner,Jennifer

Polygenic risk alters the penetrance of monogenic kidney disease.

• DOI: 10.1038/s41467-023-43878-9
• 发表时间: 2023-12-14
• 期刊: NATURE COMMUNICATIONS
• 影响因子: 16.6
• 作者: Khan, Atlas;Shang, Ning;Nestor, Jordan G.;Weng, Chunhua;Hripcsak, George;Harris, Peter C.;Gharavi, Ali G.;Kiryluk, Krzysztof
• 通讯作者: Kiryluk, Krzysztof

Evaluation of Depression and Anxiety in a Diverse Population With Thyroid Eye Disease Using the Nationwide NIH All of Us Database.

使用全国 NIH 所有人数据库对不同甲状腺眼病人群的抑郁和焦虑进行评估。

• DOI: 10.1097/iop.0000000000002318
• 发表时间: 2023
• 期刊: Ophthalmic plastic and reconstructive surgery
• 影响因子: 2
• 作者: Lee,TonyaC;Radha-Saseendrakumar,Bharanidharan;Delavar,Arash;Ye,GordonY;Ting,MichelleA;Topilow,NicoleJ;Bass,Jeremy;Korn,BobbyS;Kikkawa,DonO;Baxter,SallyL;Liu,CatherineY
• 通讯作者: Liu,CatherineY