A Pipeline for Research, Education and Mentoring in Reproductive Aging

生殖衰老研究、教育和指导渠道

• 批准号: 10663641
• 负责人: Arjumand Ghazi
• 金额: $ 12.08万
• 依托单位: UNIVERSITY OF PITTSBURGH AT PITTSBURGH
• 依托单位国家: 美国
• 财政年份: 2023
• 资助国家: 美国
• 起止时间: 2023-05-15 至 2028-01-31
• 项目状态: 未结题
• 来源: https://reporter.nih.gov/project-details/10663641
• 关键词: Address; Aging; Animals; Area; Attention; Award; Bachelor' s Degree; Basic Science; Biology; Brothers; Cardiovascular Diseases; Career Choice; Career Mobility; Clinic; Clinical; Committee Members; Communities; Country; Coupled; Dedications; Delayed Childbearing; Deterioration; Development; Diverse Workforce; Economics; Education; Educational Curriculum; Educational workshop; Elderly; Enrollment; Epidemiology; Exhibits; Faculty; Fellowship; Female; Fertility; Foundations; Funding; Future; Geriatrics; Geroscience; Goals; Graduate Degree; Health; Health Sciences; Human; Impaired cognition; Impairment; Infrastructure; Institution; Intervention; Knowledge; Lead; Leadership; Life; Life Expectancy; Link; Longevity; Medical Students; Menopause; Mentors; Mentorship; Molecular; Neurologic; Newsletter; Osteoporosis; Outcome; Participant; Pathway interactions; Positioning Attribute; Postdoctoral Fellow; Predisposition; Pregnancy; Public Health; Reproduction; Reproductive Health; Reproductive system; Research; Research Institute; Research Personnel; Science; Students; System; Talents; Testosterone; Therapeutic; Tissues; Training; Travel; Universities; Woman; age related; aging population; anti aging; career; comorbidity; experience; female fertility; graduate student; healthspan; healthy aging; interest; men; mortality; preservation; programs; recruit; reproductive; reproductive fitness; reproductive senescence; sabbatical; sex; summer research; trend; undergraduate student; web site

A Pipeline for Research, Education and Mentoring in Reproductive Aging Decline in female fertility is one of the earliest age-related deteriorations seen in humans, often decades before signs of somatic aging appear. From a fertility perspective, women are considered geriatric by late 30s and only ~5% experience successful natural pregnancies in their 40s. Besides fertility, menopause triggers a spectrum of negative health outcomes including increased susceptibility to cognitive decline and cardiovascular disease. Increased human life expectancy coupled to global trends of delayed child-bearing means that reproductive fitness is not only important for womens’ health, life- and career- choices, but has inescapable societal, economic and public-health implications. An expanding body of evidence reveals that reproductive senescence and somatic aging are mechanistically intimately linked. In the last two decades, support from the NIA, and others, has led to innumerable discoveries in organismal aging from basic mechanisms to potential anti-aging therapeutics. However, reproductive aging remains under-studied and its public-health significance poorly acknowledged. To develop an intellectual workforce well equipped to meet the current and future challenges of an aging population, it is critical to urgently prioritize the intersection of aging and reproduction as a focus of research, education and biomedical programs. Dr. Ghazi proposes to address this need through this K07 Academic Leadership Career award, by establishing a Pipeline for Reproductive-Aging Research, Education & Mentorship (PRAM) that spans the undergraduate-to-faculty spectrum at the University of Pittsburgh (Pitt). The central goal of this application is to create a program that will help establish Pitt as a world leader in reproductive aging. The K07 leadership award will help attain this goal by facilitating the development of a ‘pipeline’ at the university for (a) Early Recruitment (Aim 1): attract students from early academic stages towards reproductive-aging research, (b) Exceptional Education (Aim 2): organize a strong educational curriculum focused on reproductive health and aging, and (c) Sustained Mentorship (Aim 3): provide personalized, long-term mentorship and community support for researchers in this area at every career stage. Dr. Ghazi is uniquely positioned to lead this initiative because of her long-standing research expertise in aging, reproduction and their intersection, her academic leadership experience and commitment to education and mentoring. Pitt is an ideal institution for this initiative because of the presence of highly-regarded centers specifically dedicated to research on aging and reproductive health, an exemplary research and funding record, and a large, diverse pool of undergraduate, graduate and medical students. Pitt-PRAM will help establish reproductive aging as a core institutional objective at Pitt and serve as a roadmap to build an exceptionally trained Reproductive Geroscience workforce of the future.

研究，教育和指导的生殖衰老的管道 女性生育能力的下降是人类中最早的与年龄相关的缺陷之一，通常是几十年来 躯体衰老外观的迹象。从生育率的角度来看，妇女在30年代末被视为老年病， 在40多岁时，只有约5％的人经历了成功的天然怀孕。除了生育能力，更年期还触发了 负面健康结果的范围，包括增加对认知能力下降的敏感性和 心血管疾病。人类预期寿命的增加与延迟育儿的全球趋势相结合 意味着生殖健身不仅对妇女的健康，生活和职业选择很重要，而且具有 不可避免的社会，经济和公共卫生的影响。广泛的证据表明， 生殖感应和躯体衰老与机械上紧密相关。在过去的二十年中， NIA和其他人的支持导致了基本的有机衰老中无数的发现 潜在抗衰老疗法的机制。但是，生殖衰老仍未研究，其 公共卫生意义的认可很差。建立一个能够满足的知识劳动力队伍 当前和未来人口的挑战，紧急优先考虑衰老的交集至关重要 并繁殖是研究，教育和生物医学计划的重点。 Ghazi博士的提议通过建立这一K07学术领导职业奖，以满足这一需求 跨越生殖研究，教育与指导（PRAM）的管道 匹兹堡大学（皮特）的本科生到教学界。此应用的核心目标是 创建一个计划，该程序将帮助建立皮特成为生殖衰老领域的世界领导者。 K07领导奖 将通过支持大学的“管道”开发（a）早期招聘，从而帮助实现这一目标 （AIM 1）：吸引从早期学术阶段的学生进入生殖研究，（b）特殊 教育（目标2）：组织一个专注于生殖健康和衰老的强大教育课程，以及（c） 持续指导（AIM 3）：提供个性化的，长期的指导和社区支持 在每个职业阶段，该领域的研究人员。 Ghazi博士的独特位置可以领导这项倡议 她在衰老，繁殖和交叉路口方面的长期研究专业知识，她的学术领导 经验和对教育和心理的承诺。皮特是该计划的理想机构 备受推崇的中心的存在专门用于研究衰老和复制健康的研究， 典范研究和资助记录，以及大型的潜水员本科，研究生和医学 学生。皮特 - 普拉姆（Pitt-Pram）将有助于建立生殖老化，成为皮特（Pitt 一个路线图，以建立一个训练有素的生殖性Geroscience劳动力。