Emerging Infectious Diseases Research Centers Coordination Center (EIDRC CC)

新发传染病研究中心协调中心 (EIDRC CC)

• 批准号: 10616668
• 负责人: Michael Anthony Moody
• 金额: $ 245.09万
• 依托单位: RESEARCH TRIANGLE INSTITUTE
• 依托单位国家: 美国
• 财政年份: 2020
• 资助国家: 美国
• 起止时间: 2020-05-18 至 2025-04-30
• 项目状态: 未结题
• 来源: https://reporter.nih.gov/project-details/10616668
• 关键词: Address; Affect; Area; Award; Benchmarking; Biological Assay; Biology; Central Africa; Central America; Childhood; Collaborations; Communicable Diseases; Communication; Consensus; Coordination and Collaboration; Country; Data; Disease; Disease Outbreaks; Doctor of Philosophy; Emerging Communicable Diseases; Ensure; Epidemic; Event; Frequencies; Funding; Geographic Locations; Goals; Health; Home; Human; Infectious Diseases Research; Information Management; Infrastructure; International; Joints; Knowledge; Laboratories; Leadership; Location; Medical; Medical Research; Mentors; Morbidity - disease rate; National Institute of Allergy and Infectious Disease; Performance; Persons; Principal Investigator; Privatization; Procedures; Process; Protocols documentation; Reagent; Research; Research Design; Research Infrastructure; Research Personnel; Resource Sharing; Resources; Scientist; Security; Site; Southeastern Asia; Specialist; Specimen; System; Testing; Training; United States; United States National Institutes of Health; Universities; Vaccines; ZIKA; career; cloud based; data acquisition; data quality; disease transmission; electronic data capture system; experience; flexibility; high risk; improved; mortality; next generation; programs; quality assurance; repository; response; social media; success; usability; web site

PROJECT SUMMARY/ABSTRACT Emerging and re-emerging infectious disease (EID) outbreaks that are occurring with increasing frequency in high-risk areas in South/Central America, West/Central Africa, and Southeast Asia are a threat to the United States. Documented gaps in research infrastructure limit the capacity to rapidly respond to these outbreaks. To address this challenge, the National Institute of Allergy and Infectious Diseases (NIAID) is establishing the Emerging Infectious Disease Research Centers Network (EIDRC-Net) to improve knowledge of EIDs; leverage existing NIAID international efforts; and develop the capacity to mount effective, flexible, and rapid outbreak research responses. RTI International and Duke University propose to establish the EIDRC Coordination Center (EIDRC CC). The RTI-Duke CC will support the EIDRC-Net, which will comprise the EIDRCs, research sites, the CC, and NIAID by realizing the following aims: (1) enhance EIDRC coordination and collaboration by providing administrative, communications, logistical, and operational support; (2) amplify NIAID's capabilities and reach by coordinating and supporting a sustainable, scalable, and adaptable research infrastructure to optimize resources and knowledge sharing during inter-outbreak periods and to respond rapidly and effectively during outbreaks; (3) ensure quality and consistency of study data by using rigorous data and specimen management systems with built-in data quality assurance; (4) ensure quality of biospecimens, assays, and reagents through harmonization of standard operating procedures across EIDRC-Net sites and ongoing audit of cross-network procedures; and (5) develop the next generation of investigators and in-country scientists by establishing a pilot research program that identifies, funds, and mentors high-quality EIDRC applicants. By successfully accomplishing our five specific aims, the RTI-Duke team will shift the outbreak research response paradigm by establishing scalable systems, processes, and resources that not only provide the necessary infrastructure to facilitate EIDRC-Net performance and carry out CC core functions during inter-outbreak periods, but also can be enhanced and expanded to bolster CC research surge response activities during outbreaks. The EIDRC CC team will be co-led by multiple Principal Investigators Donald Brambilla, PhD (RTI), a biostatistician with advanced training in biology and an experienced CC leader, and Michael Anthony (Tony) Moody, MD (Duke), a pediatric infectious disease specialist and Chief Medical Officer of the Duke Human Vaccine Institute. Together they bring extensive scientific expertise, leadership, administrative experience, and international research expertise, including in geographic locations most relevant to the study of EIDs. This partnership also leverages the operational efficiency of RTI, a large nonprofit research organization with regional and project offices in over 75 countries, with the scientific rigor of Duke University, a premier university known for its cutting-edge medical research and home to a state-of-the-art, NIAID-funded Regional Biocontainment Laboratory.

项目摘要/摘要 出现和重新出现的传染病（EID）暴发，随着频率的增加而发生 南美洲，西/中非和东南亚的高风险地区对联合 国家。研究基础设施中有记录的差距限制了快速响应这些暴发的能力。 为了应对这一挑战，美国国家过敏和传染病研究所（NIAID）正在建立 新兴的传染病研究中心网络（EIDRC-NET），以提高EID的知识； 利用现有的NIAID国际努力；并发展有效，灵活和快速的能力 爆发研究反应。 RTI International和Duke University提议建立EIDRC 协调中心（EIDRC CC）。 RTI-Duke CC将支持EIDRC-NET，该网络将包括 通过实现以下目的，EIDRC，研究站点，CC和NIAID：（1）增强EIDRC协调 通过提供行政，沟通，后勤和运营支持来协作； （2） 通过协调和支持可持续，可扩展和适应性的来扩大NIAID的能力并达到 研究基础架构，以优化爆发期间的资源和知识共享 爆发期间迅速有效地做出反应； （3）通过使用研究数据的质量和一致性 具有内置数据质量保证的严格数据和标本管理系统； （4）确保质量 通过协调跨越标准操作程定的生物测量，测定和试剂 EIDRC网站和跨网络程序的持续审核； （5）发展下一代 调查人员和国内科学家建立了一项试点研究计划，该计划识别，资金和 导师高质量的EIDRC申请人。通过成功完成我们的五个特定目标，RTI-Duke 团队将通过建立可扩展系统，流程和 不仅提供必要的基础架构来促进EIDRC-NET性能并携带的资源 在爆发期间出现CC核心功能，但也可以增强并扩展到Bolster CC 爆发期间的研究激增反应活动。 EIDRC CC团队将由多个校长共同领导 研究人员唐纳德·布拉比拉（Donald Brambilla）博士（RTI），生物学培训和生物学培训的生物统计学家 经验丰富的CC领导者和小儿传染病的Michael Anthony（Tony）Moody，医学博士（Duke） 人类疫苗研究所的专家兼首席医疗官。他们一起带来了广泛的 科学专业知识，领导力，行政经验和国际研究专业知识，包括 地理位置与开斋节的研究最相关。这种伙伴关系还利用了运营 RTI的效率，RTI是一个大型的非营利研究组织，拥有75多个区域和项目办公室 国家，杜克大学的科学严谨，一所以其尖端医学而闻名 研究和最先进的，NIAID资助的区域生物疗养实验室的所在地。