Emerging Infectious Diseases Research Centers Coordination Center (EIDRC CC)

新发传染病研究中心协调中心 (EIDRC CC)

• 批准号: 10891936
• 负责人: Michael Anthony Moody
• 金额: $ 35.91万
• 依托单位: RESEARCH TRIANGLE INSTITUTE
• 依托单位国家: 美国
• 财政年份: 2020
• 资助国家: 美国
• 起止时间: 2020-05-18 至 2025-04-30
• 项目状态: 未结题
• 来源: https://reporter.nih.gov/project-details/10891936
• 关键词: Address; Affect; Area; Award; Benchmarking; Biological Assay; Biology; Central Africa; Central America; Childhood; Collaborations; Communicable Diseases; Communication; Consensus; Coordination and Collaboration; Country; Data; Disease; Disease Outbreaks; Doctor of Philosophy; Emerging Communicable Diseases; Ensure; Epidemic; Event; Frequencies; Funding; Geographic Locations; Goals; Health; Home; Human; Infectious Diseases Research; Information Management; Infrastructure; International; Joints; Knowledge; Laboratories; Leadership; Location; Medical; Medical Research; Mentors; Morbidity - disease rate; National Institute of Allergy and Infectious Disease; Performance; Persons; Principal Investigator; Privatization; Procedures; Process; Protocols documentation; Reagent; Research; Research Design; Research Infrastructure; Research Personnel; Resource Sharing; Resources; Scientist; Security; Site; Southeastern Asia; Specialist; Specimen; System; Testing; Training; United States; United States National Institutes of Health; Universities; Vaccines; ZIKA; career; cloud based; data acquisition; data quality; disease transmission; electronic data capture system; experience; flexibility; high risk; improved; mortality; next generation; programs; quality assurance; repository; response; social media; success; usability; web site

PROJECT SUMMARY/ABSTRACT Emerging and re-emerging infectious disease (EID) outbreaks that are occurring with increasing frequency in high-risk areas in South/Central America, West/Central Africa, and Southeast Asia are a threat to the United States. Documented gaps in research infrastructure limit the capacity to rapidly respond to these outbreaks. To address this challenge, the National Institute of Allergy and Infectious Diseases (NIAID) is establishing the Emerging Infectious Disease Research Centers Network (EIDRC-Net) to improve knowledge of EIDs; leverage existing NIAID international efforts; and develop the capacity to mount effective, flexible, and rapid outbreak research responses. RTI International and Duke University propose to establish the EIDRC Coordination Center (EIDRC CC). The RTI-Duke CC will support the EIDRC-Net, which will comprise the EIDRCs, research sites, the CC, and NIAID by realizing the following aims: (1) enhance EIDRC coordination and collaboration by providing administrative, communications, logistical, and operational support; (2) amplify NIAID's capabilities and reach by coordinating and supporting a sustainable, scalable, and adaptable research infrastructure to optimize resources and knowledge sharing during inter-outbreak periods and to respond rapidly and effectively during outbreaks; (3) ensure quality and consistency of study data by using rigorous data and specimen management systems with built-in data quality assurance; (4) ensure quality of biospecimens, assays, and reagents through harmonization of standard operating procedures across EIDRC-Net sites and ongoing audit of cross-network procedures; and (5) develop the next generation of investigators and in-country scientists by establishing a pilot research program that identifies, funds, and mentors high-quality EIDRC applicants. By successfully accomplishing our five specific aims, the RTI-Duke team will shift the outbreak research response paradigm by establishing scalable systems, processes, and resources that not only provide the necessary infrastructure to facilitate EIDRC-Net performance and carry out CC core functions during inter-outbreak periods, but also can be enhanced and expanded to bolster CC research surge response activities during outbreaks. The EIDRC CC team will be co-led by multiple Principal Investigators Donald Brambilla, PhD (RTI), a biostatistician with advanced training in biology and an experienced CC leader, and Michael Anthony (Tony) Moody, MD (Duke), a pediatric infectious disease specialist and Chief Medical Officer of the Duke Human Vaccine Institute. Together they bring extensive scientific expertise, leadership, administrative experience, and international research expertise, including in geographic locations most relevant to the study of EIDs. This partnership also leverages the operational efficiency of RTI, a large nonprofit research organization with regional and project offices in over 75 countries, with the scientific rigor of Duke University, a premier university known for its cutting-edge medical research and home to a state-of-the-art, NIAID-funded Regional Biocontainment Laboratory.

项目概要/摘要 新发和再发传染病 (EID) 的爆发频率越来越高 南美洲/中美洲、西非/中非和东南亚的高风险地区对美国构成威胁 国家。研究基础设施方面记录的差距限制了快速应对这些疫情的能力。 为了应对这一挑战，国家过敏和传染病研究所 (NIAID) 正在建立 新兴传染病研究中心网络 (EIDRC-Net)，以提高对 EID 的了解； 利用现有的 NIAID 国际努力；并培养有效、灵活、快速的安装能力 疫情研究应对措施。 RTI International 与杜克大学提议成立 EIDRC 协调中心（EIDRC CC）。 RTI-Duke CC 将支持 EIDRC-Net，其中包括 EIDRC、研究中心、CC 和 NIAID 通过实现以下目标： (1) 加强 EIDRC 协调 通过提供行政、通信、后勤和运营支持进行协作； (2) 通过协调和支持可持续、可扩展和适应性强的项目，扩大 NIAID 的能力和影响范围 研究基础设施，以优化爆发期间的资源和知识共享，并 疫情爆发期间迅速有效地做出反应； （3）通过使用保证研究数据的质量和一致性 严格的数据和样本管理系统，具有内置的数据质量保证； （四）保证质量 通过统一标准操作程序来提供生物样本、分析方法和试剂 EIDRC-Net 站点和跨网络程序的持续审计； (5) 开发下一代 通过建立试点研究计划来识别、资助和资助研究人员和国内科学家 指导高质量的 EIDRC 申请人。通过成功实现我们的五个具体目标，RTI-Duke 团队将通过建立可扩展的系统、流程和 资源不仅提供必要的基础设施来促进 EIDRC-Net 的性能并承载 可以在两次爆发期间发挥 CC 的核心功能，但也可以增强和扩展以支持 CC 研究疫情暴发期间的激增应对活动。 EIDRC CC 团队将由多位负责人共同领导 研究人员 Donald Brambilla 博士 (RTI)，一位接受过高级生物学培训的生物统计学家， 经验丰富的 CC 领导者，以及儿科传染病医学博士 Michael Anthony (Tony) Moody 杜克人类疫苗研究所专家兼首席医疗官。他们共同带来了广泛的 科学专业知识、领导力、管理经验和国际研究专业知识，包括 与 EID 研究最相关的地理位置。这种伙伴关系还利用了运营 RTI 是一家大型非营利研究组织，在超过 75 个地区设有区域和项目办事处 杜克大学是一所以其尖端医学而闻名的一流大学，具有严谨的科学性 该实验室是 NIAID 资助的最先进的区域生物防护实验室的所在地。