Monoclonal antibodies against surface epitopes of Treponema pallidum outer membrane proteins

抗梅毒螺旋体外膜蛋白表面表位的单克隆抗体

基本信息

批准号：
10618194
负责人：
Michael Anthony Moody
金额：
$ 57.37万
依托单位：
UNIVERSITY OF CONNECTICUT SCH OF MED/DNT
依托单位国家：
美国
项目类别：
财政年份：
2019
资助国家：
美国
起止时间：
2019-05-01 至 2025-04-30
项目状态：
未结题

来源：
https://reporter.nih.gov/project-details/10618194
关键词：
Affect Algorithms Animal Model Animals Antibodies Antigens B-Lymphocytes Bacteriophages Binding Cell Lineage Clinical Clinical Trials Collaborations Collection Data Diagnostic tests Disease Economically Deprived Population Epitopes Extracellular Protein Genetic Genomics Goals HIV-1 vaccine Human Immune Immune Tolerance Immunologic Factors Immunology In Vitro Infection Knowledge Latent Syphilis Libraries Macrophage Mediating Membrane Proteins Modeling Monoclonal Antibodies Mus Natural History Order Spirochaetales Oryctolagus cuniculus Outcome Patients Peripheral Blood Mononuclear Cell Persons Phage Display Public Health Reagent Research Technics Sampling Sexually Transmitted Diseases Specificity Speed Surface Syphilis Techniques Testing Treponema pallidum Treponema pallidum subspecies pallidum Vaccine Design Variant Work design effective therapy expectation extracellular human monoclonal antibodies immunogenicity longitudinal human study low socioeconomic status men who have sex with men novel novel vaccines passive antibodies pressure programs syphilis vaccine vaccine candidate vaccine development vaccine strategy vaccinology

项目摘要

ABSTRACT-Project 3: Immunology Syphilis is a sexually transmitted infection caused by Treponema pallidum that remains a significant public health threat. Despite effective testing and treatment algorithms, the rate of syphilis infections is increasing in the US, especially among economically disadvantaged persons. Development of a vaccine will speed elimination of this disease and reduce the burden of syphilis complications including congenital disease. This overall goal of this program is to develop syphilis vaccine candidates, and this project is designed to characterize the immunological factors associated with protection. This project will isolate, characterize, and test monoclonal antibodies against syphilis derived from clinical samples obtained by our collaborators as well as antibodies that are developed in vitro using phage display techniques. The outcome of this work will be a new set of vaccine candidates that can be advanced to clinical trials.

抽象项目3：免疫学梅毒是由treponema Pallidum引起的性传播感染，仍然是一个重要的公众健康威胁。尽管进行了有效的测试和治疗算法，但梅毒感染的发生率正在增加美国，尤其是在经济不利的人中。疫苗的开发将加快消除这种疾病并减轻包括先天性疾病在内的梅毒并发症的负担。这该计划的总体目标是开发梅毒疫苗候选者，该项目旨在表征与保护相关的免疫因素。该项目将隔离，特征，并且测试来自我们合作者获得的临床样本衍生的梅毒的单克隆抗体作为使用噬菌体显示技术在体外开发的抗体。这项工作的结果将是可以将新的疫苗候选物提升到临床试验。