ASSESSMENT OF COGNITIVE FUNCTION AND RELATIONSHIP TO STRESS REACTIVITY

认知功能及其与应激反应关系的评估

• 批准号: 7958342
• 负责人: Melinda Ann Novak
• 金额: $ 6.49万
• 依托单位: HARVARD MEDICAL SCHOOL
• 依托单位国家: 美国
• 财政年份: 2009
• 资助国家: 美国
• 起止时间: 2009-05-01 至 2010-04-30
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/7958342
• 关键词: Cognitive; Computer Retrieval of Information on Scientific Projects Database; Face; Funding; Glucocorticoids; Grant; Human; Hydrocortisone; Institution; Memory; Modeling; Monkeys; New England; Performance; Population Study; Primates; Research; Research Personnel; Resources; Short-Term Memory; Source; Stress; Testing; United States National Institutes of Health; base; cognitive function; memory recognition; stressor

This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. The subproject and investigator (PI) may have received primary funding from another NIH source, and thus could be represented in other CRISP entries. The institution listed is for the Center, which is not necessarily the institution for the investigator. Considerable research has focused on the relationship between glucocorticoid levels and cognitive performance. In humans, high levels of cortisol produced by stressors or by administration of glucocorticoids have deleterious effects on declarative memory, face recognition memory, and working memory. However, there is little research on the impact of reduced stress reactivity on cognitive performance. Such research requires either reducing glucocorticoid levels experimentally or studying populations with lower stress reactivity. We have previously shown that monkeys with SIB have lower stress reactivity than controls. Thus, they provide an important model with which to test whether naturally-occurring lower stress responsiveness is associated with increased cognitive performance.

该子项目是利用该技术的众多研究子项目之一 资源由 NIH/NCRR 资助的中心拨款提供。子项目及 研究者 (PI) 可能已从 NIH 的另一个来源获得主要资金， 因此可以在其他 CRISP 条目中表示。列出的机构是 中心，不一定是研究者的机构。 大量研究集中在糖皮质激素水平与认知表现之间的关系。 在人类中，压力源或糖皮质激素产生的高水平皮质醇会对陈述性记忆、面部识别记忆和工作记忆产生有害影响。 然而，关于压力反应减少对认知表现的影响的研究很少。 此类研究需要通过实验降低糖皮质激素水平或研究应激反应性较低的人群。我们之前已经证明，患有 SIB 的猴子的应激反应性低于对照组。 因此，他们提供了一个重要的模型来测试自然发生的较低压力反应是否与认知能力的提高相关。