DTI IN WILLIAMS SYNDROME

DTI 在威廉姆斯综合征中的应用

• 批准号: 8169866
• 负责人: FUMIKO HOEFT
• 金额: $ 1.23万
• 依托单位: STANFORD UNIVERSITY
• 依托单位国家: 美国
• 财政年份: 2010
• 资助国家: 美国
• 起止时间: 2010-07-01 至 2011-03-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/8169866
• 关键词: Brain region; Cognitive; Computer Retrieval of Information on Scientific Projects Database; Control Groups; Data; Diffusion Magnetic Resonance Imaging; Dorsal; Face; Fiber; Funding; Genetic; Grant; Individual; Institution; Link; Methods; Process; Relative (related person); Research; Research Personnel; Resources; Source; Stream; United States National Institutes of Health; Visuospatial; Williams Syndrome; interest; neuroimaging; white matter

This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. The subproject and investigator (PI) may have received primary funding from another NIH source, and thus could be represented in other CRISP entries. The institution listed is for the Center, which is not necessarily the institution for the investigator. Cognitive hallmarks of Williams syndrome (WS) include severe visuospatial deficits, and relative strengths in face and object processing (Meyer-Lindenberg et al., 2006). Functional neuroimaging data has indicated anomalous functional connectivity of the dorsal stream in WS. Specific Aims: To investigate whether WS has aberrant connectivity of dorsal stream white matter tracts which may link between genetic and visuospatial abnormalities in WS. Methods: We used diffusion tensor imaging to examine white matter integrity in the dorsal and ventral streams among individuals with Williams syndrome (WS) compared to two control groups (typically developing and developmentally delayed) and using three separate analysis methods (whole brain, region of interest, and fiber tractography).

该子项目是利用该技术的众多研究子项目之一 资源由 NIH/NCRR 资助的中心拨款提供。子项目及 研究者 (PI) 可能已从 NIH 的另一个来源获得主要资金， 因此可以在其他 CRISP 条目中表示。列出的机构是 中心，不一定是研究者的机构。 威廉姆斯综合征 (WS) 的认知特征包括严重的视觉空间缺陷以及面部和物体处理的相对优势（Meyer-Lindenberg 等，2006）。功能神经影像数据表明 WS 背侧流的功能连接异常。 具体目标： 旨在研究 WS 是否具有背流白质束的异常连接，这可能与 WS 的遗传和视觉空间异常之间存在联系。 方法： 我们使用弥散张量成像来检查威廉姆斯综合征 (WS) 个体背侧和腹侧流中白质的完整性，并与两个对照组（通常发育和发育迟缓）进行比较，并使用三种独立的分析方法（全脑、感兴趣区域、和纤维束成像）。