NEURAL SUBSTRATES OF MINDFULNESS MEDITATION FOR SOCIAL ANXIETY DISORDER

正念冥想治疗社交焦虑症的神经基础

基本信息

批准号：
8169845
负责人：
PHILIPPE R GOLDIN
金额：
$ 1.85万
依托单位：
STANFORD UNIVERSITY
依托单位国家：
美国
项目类别：
财政年份：
2010
资助国家：
美国
起止时间：
2010-07-01 至 2011-03-31
项目状态：
已结题

来源：
https://reporter.nih.gov/project-details/8169845
关键词：
21 year old Address Adult Aftercare Anxiety Anxiety Disorders Applications Grants Basic Science Behavior assessment Behavioral Brain region Clinical Clinical Research Cognitive Computer Retrieval of Information on Scientific Projects Database Computers DSM-IV Data Diagnosis Diagnostic Dorsal Emotional Emotions Enrollment Equipment and supply inventories Exercise Functional Magnetic Resonance Imaging Funding Future Goals Grant Health Institution Intervention Interview Literature Mediating Mediator of activation protein Meditation Methods Participant Patient Self-Report Personal Satisfaction Population Questionnaires Randomized Regulation Research Research Design Research Personnel Resources Sample Size Scientific Evaluation Social Phobia Source Stimulus Stress Time United States National Institutes of Health active control base emotion regulation follow-up improved indexing meetings mindfulness meditation mindfulness-based stress reduction neuromechanism psychological distress relating to nervous system social treatment response

项目摘要

This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. The subproject and investigator (PI) may have received primary funding from another NIH source, and thus could be represented in other CRISP entries. The institution listed is for the Center, which is not necessarily the institution for the investigator. Introduction This study is comparing the effect of mindfulness meditation based stress reduction versus wellness/exercise based stress reduction on the neural bases of emotional reactivity and regulation in adults diagnosed with social anxiety disorder. Specific Aims The overall goal of this proposal is to identify the neural mechanisms underlying changes associated with Mindfulness-Based Stress Reduction (MBSR). Clinical research has shown that MBSR reduces psychological distress and increases well-being [12], [13], [14], but the mechanisms underlying these changes are not well described. Basic research has examined the neural bases of emotion and emotion regulation in healthy controls (HC) [15, 16], but this research has not examined changes following MBSR. To integrate clinical and basic research literatures, we use a translational framework that characterizes the impact of MBSR on emotion regulation in terms of interactions between ventral emotion-generative brain regions and dorsal emotion-regulatory brain regions. Within this framework, we propose to compare the effects of MBSR and an active control condition on emotional regulation in participants with generalized social phobia (SP). Participants will be randomly assigned either to MBSR or to an active control condition (ACC), namely a drawing class. All participants will be assessed using self-report inventories and functional magnetic resonance imaging (fMRI) before and after MBSR and ACC. Three aims will be addressed: Aim 1 investigates the effects of MBSR on general levels of anxiety and well-being. Aim 2 investigates the effects of MBSR on attentional and cognitive emotion regulation. Aim 3 investigates whether MBSR-related changes in attentional emotion regulation mediate MBSR treatment response (decreases in anxiety and increases in well-being) at post-treatment and at the 3-month follow-up. The long-term objective of this research is to contribute to the scientific evaluation of meditation interventions that hold promise for improving health and well-being in clinical and non-clinical populations. Methods and Materials We intend to enroll 60 adults (ages 21-55 years) who will meet DSM-IV [101] criteria for a principal diagnosis of generalized social phobia (SP) at Time 1 baseline. SP will be randomly assigned to MBSR or ACC. This sample size will provide sufficient power to investigate the effects of MBSR on both behavioral and neural indices of emotional reactivity and regulation, and to examine potential mediators of the effects of MBSR. As we describe in the final section (below), data from these 60 participants will serve as a firm basis for making research design and experimental stimulus decisions for our future R01 grant proposal. All participants will undergo diagnostic interviewing, behavioral assessment, a battery of questionnaires, computer task, and fMRI task to assess facets of anxiety, emotional reactivity and regulation

该子项目是利用该技术的众多研究子项目之一资源由 NIH/NCRR 资助的中心拨款提供。子项目及研究者 (PI) 可能已从 NIH 的另一个来源获得主要资金，因此可以在其他 CRISP 条目中表示。列出的机构是中心，不一定是研究者的机构。介绍这项研究正在比较基于正念冥想的减压与基于健康/运动的减压对被诊断患有社交焦虑症的成年人情绪反应和调节的神经基础的影响。具体目标该提案的总体目标是确定与基于正念的减压（MBSR）相关的变化背后的神经机制。临床研究表明，MBSR 可减少心理困扰并增加幸福感 [12]、[13]、[14]，但这些变化背后的机制尚未得到很好的描述。基础研究检查了健康对照 (HC) 中情绪和情绪调节的神经基础 [15, 16]，但本研究尚未检查 MBSR 后的变化。为了整合临床和基础研究文献，我们使用一个翻译框架，从腹侧情绪生成脑区和背侧情绪调节脑区之间的相互作用来描述 MBSR 对情绪调节的影响。在此框架内，我们建议比较MBSR和主动控制条件对广泛性社交恐惧症（SP）参与者情绪调节的影响。参与者将被随机分配到 MBSR 或主动控制条件 (ACC)，即绘画班。在 MBSR 和 ACC 之前和之后，所有参与者都将使用自我报告清单和功能磁共振成像 (fMRI) 进行评估。将实现三个目标：目标 1 研究 MBSR 对总体焦虑和幸福水平的影响。目标 2 研究 MBSR 对注意力和认知情绪调节的影响。目标 3 研究在治疗后和 3 个月的随访中与 MBSR 相关的注意力情绪调节变化是否介导 MBSR 治疗反应（焦虑减少和幸福感增加）。这项研究的长期目标是促进对冥想干预措施的科学评估，这些干预措施有望改善临床和非临床人群的健康和福祉。方法和材料我们打算招募 60 名成年人（年龄 21-55 岁），他们将符合 DSM-IV [101] 在时间 1 基线时广泛性社交恐惧症 (SP) 主要诊断的标准。 SP将被随机分配给MBSR或ACC。这个样本量将提供足够的力量来研究MBSR对情绪反应和调节的行为和神经指数的影响，并检查MBSR影响的潜在中介因素。正如我们在最后一节（下文）中所述，这 60 名参与者的数据将作为我们未来 R01 拨款提案的研究设计和实验刺激决策的坚实基础。所有参与者都将接受诊断访谈、行为评估、一系列问卷、计算机任务和功能磁共振成像任务，以评估焦虑、情绪反应和调节的各个方面