FUNCTIONAL CORRELATES OF PREFRONTAL AND STRIATAL INFORMATION PROCESSING

前额叶和纹状体信息处理的功能关联

• 批准号: 8167257
• 负责人: MIKLOS ARGYELAN
• 金额: $ 0.85万
• 依托单位: FEINSTEIN INSTITUTE FOR MEDICAL RESEARCH
• 依托单位国家: 美国
• 财政年份: 2010
• 资助国家: 美国
• 起止时间: 2010-04-01 至 2011-03-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/8167257
• 关键词: Affect; Alzheimer' s Disease; Brain region; Cognitive; Cognitive deficits; Computer Retrieval of Information on Scientific Projects Database; Corpus striatum structure; Data; Disease; Dystonia; Functional Magnetic Resonance Imaging; Funding; Gilles de la Tourette syndrome; Grant; Huntington Disease; Impaired cognition; Impairment; Institution; Mediating; Nerve Degeneration; Neurodegenerative Disorders; Neurodevelopmental Disorder; Parkinson Disease; Pathway interactions; Physiological; Research; Research Personnel; Resources; Schizophrenia; Source; Syndrome; Thalamic structure; United States National Institutes of Health; base; frontal lobe; information processing; neuropsychological

This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. The subproject and investigator (PI) may have received primary funding from another NIH source, and thus could be represented in other CRISP entries. The institution listed is for the Center, which is not necessarily the institution for the investigator. Impairment in frontostriatally based executive tasks represents an overlapping feature in neurodegenerative and neurodevelopmental disorders affecting the cortico-striatal-pallido-thalamic loops (CSPTC) and related pathways, such as Parkinson's disease, Huntington's disease, Alzheimer's disease, minimal cognitive impairment, dystonia syndromes, Tourette's syndrome and schizophrenia spectrum disorders. However, the mechanism by which this cognitive impairment is mediated is likely to vary across diseases according to the primarily affected brain regions. Our general hypothesis, based on preliminary data, is that impaired activation of frontal and/or striatal regions is responsible for impaired prefrontal information processing in neurodegenerative diseases affecting CSTPC regions. By contrast impairment in the functional connectivity between the frontal cortex and the striatum is hypothesized to be responsible for impaired prefrontal information processing in neurodevelopmental disorders affecting CSTPC function. Using a combined neuropsychological and functional magnetic resonance imaging approach, we plan to study functional correlates of cognitive tasks involving mainly prefrontal information processing. Together, these studies will provide important information concerning the physiological mechanisms that underlie cognitive deficits in these disorders.

该子项目是利用该技术的众多研究子项目之一 资源由 NIH/NCRR 资助的中心拨款提供。子项目及 研究者 (PI) 可能已从 NIH 的另一个来源获得主要资金， 因此可以在其他 CRISP 条目中表示。列出的机构是 中心，不一定是研究者的机构。 基于额纹状体的执行任务的损伤代表了影响皮质-纹状体-苍白球-丘脑环（CSPTC）和相关通路的神经退行性和神经发育障碍的重叠特征，例如帕金森病、亨廷顿病、阿尔茨海默病、轻微认知障碍、肌张力障碍综合征、妥瑞氏综合症和精神分裂症谱系障碍。然而，根据主要受影响的大脑区域，介导这种认知障碍的机制可能因疾病而异。 基于初步数据，我们的一般假设是，额叶和/或纹状体区域的激活受损是影响 CSTPC 区域的神经退行性疾病中前额叶信息处理受损的原因。相比之下，假设额叶皮层和纹状体之间的功能连接受损是影响 CSTPC 功能的神经发育障碍中前额叶信息处理受损的原因。使用神经心理学和功能磁共振成像相结合的方法，我们计划研究主要涉及前额叶信息处理的认知任务的功能相关性。总之，这些研究将提供有关这些疾病认知缺陷的生理机制的重要信息。