ESTABLISHING PREDICTORS OF SIB IN RHESUS MONKEYS

建立恒河猴 SIB 的预测因子

• 批准号: 8357931
• 负责人: Melinda Ann Novak
• 金额: $ 5.4万
• 依托单位: HARVARD MEDICAL SCHOOL
• 依托单位国家: 美国
• 财政年份: 2011
• 资助国家: 美国
• 起止时间: 2011-05-01 至 2012-04-30
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/8357931
• 关键词: Animal Model; Behavior; Behavior assessment; Biological Assay; Biological Markers; Clinical; Collaborations; Development; Disease; Funding; Genetic Variation; Grant; Hair; Housing; Human; Hydrocortisone; Longitudinal Studies; Macaca; Macaca mulatta; Monkeys; National Center for Research Resources; National Institute of Child Health and Human Development; New England; Opioid; Population; Prevention strategy; Primates; Principal Investigator; Research; Research Infrastructure; Resources; Risk Factors; Saliva; Sampling; Screening procedure; Source; Syndrome; United States National Institutes of Health; base; biological adaptation to stress; cohort; cost; male; novel; stereotypy

This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. Primary support for the subproject and the subproject's principal investigator may have been provided by other sources, including other NIH sources. The Total Cost listed for the subproject likely represents the estimated amount of Center infrastructure utilized by the subproject, not direct funding provided by the NCRR grant to the subproject or subproject staff. We have previously established an animal model of naturally occurring SIB in which monkeys show a reduced stress response and lower opioid levels compared to controls. Because we study monkeys only after they have spontaneously developed SIB, we do not know whether these differences are risk factors for or consequences of developing SIB. The purpose of this project is to determine whether there are early markers for the onset of SIB and stereotypic behavior. We are currently conducting a unique, large-scale longitudinal study of a cohort of male monkeys in which we are coordinating our standard behavioral assessments of abnormal behavior, collecting hair and saliva samples for cortisol and other assays, and searching for polymorphic gene variants that are predictive of later SIB or stereotypy development. We are also examining hair cortisol profiles in macaques as a function of housing, early rearing, and species (in collaboration with Dr. Stephen Suomi, NICHD). The determination of biomarkers for these syndromes can then be used for colony screening and the development of new prevention strategies. Elucidation of novel biomarkers of SIB will also have significant implications for our understanding of this disorder in human clinical populations.

该子项目是利用资源的众多研究子项目之一 由 NIH/NCRR 资助的中心拨款提供。子项目的主要支持 并且子项目的主要研究者可能是由其他来源提供的， 包括其他 NIH 来源。 子项目可能列出的总成本 代表子项目使用的中心基础设施的估计数量， NCRR 赠款不直接向子项目或子项目工作人员提供资金。 我们之前建立了一个自然发生的 SIB 动物模型，与对照组相比，猴子表现出应激反应减少和阿片类药物水平较低。 因为我们仅在猴子自发发生 SIB 后才对它们进行研究，所以我们不知道这些差异是否是发生 SIB 的危险因素或后果。 该项目的目的是确定是否存在 SIB 和刻板行为发生的早期标志。 我们目前正在对一群雄性猴子进行一项独特的大规模纵向研究，其中我们协调对异常行为的标准行为评估，收集毛发和唾液样本进行皮质醇和其他检测，并寻找与正常行为相关的多态性基因变异。预测后来的 SIB 或刻板印象的发展。 我们还研究了猕猴毛发皮质醇分布与住房、早期饲养和物种的关系（与 NICHD 的 Stephen Suomi 博士合作）。 这些综合征的生物标志物的测定可用于菌落筛查和制定新的预防策略。 SIB 的新型生物标志物的阐明也将对我们了解人类临床人群中的这种疾病产生重大影响。