Baylor College of Medicine Site Consortium - Adolescent Medicine Trials Network for HIV/AIDS Interventions (ATN) Operations and Collaborations Center (UM2 Clinical Trial Optional)

贝勒医学院站点联盟 - HIV/艾滋病干预青少年医学试验网络 (ATN) 运营和合作中心（UM2 临床试验可选）

• 批准号: 10599557
• 负责人: MARY E PAUL
• 金额: $ 30.84万
• 依托单位: WESTAT, INC.
• 依托单位国家: 美国
• 财政年份: 2022
• 资助国家: 美国
• 起止时间: 2022-09-22 至 2029-06-30
• 项目状态: 未结题
• 来源: https://reporter.nih.gov/project-details/10599557
• 关键词: AIDS/HIV problem; Acquired Immunodeficiency Syndrome; Address; Adherence; Adolescent Medicine Trials Network; Adolescent and Young Adult; Advisory Committees; Advocate; Affect; African American population; Area; Black race; COVID-19; COVID-19 pandemic; Caring; Cities; Clinical Trials; Collaborations; Communities; Conduct Clinical Trials; County; Development; Diagnosis; Discipline of Nursing; Drug Kinetics; Epidemic; Evaluation; Failure; Feedback; Future; Goals; HIV; HIV Infections; HIV diagnosis; Health; Healthcare; Heterosexuals; Hispanic; Homeless Youth; Human Resources; Human immunodeficiency virus test; Individual; Infection; Infection prevention; Intervention; Intervention Studies; Intervention Trial; Laboratories; Latino; Latinx; Lead; Leadership; Low income; Medicaid; Medical; Medicine; Minority Groups; Modality; Modeling; Online Systems; Outcome; Pediatric Hospitals; Pharmacy facility; Prevention; Reporting; Research; Risk; Services; Site; Structure; Technology; Texas; Treatment Effectiveness; Uninsured; United States; Work; Youth; age group; base; case-based; college; community engagement; design; ethnic minority population; experience; gender minority youth; health inequalities; high risk; human old age (65+); improved; innovation; male; marginalized community; meetings; member; motivational enhancement therapy; novel strategies; operation; outreach; participant enrollment; pre-exposure prophylaxis; prevent; prevention service; programs; racial minority; recruit; research study; sexual minority; testing services; transmission process; treatment services; uptake

ABSTRACT Baylor College of Medicine Harris County, which includes the City of Houston, is among the 48 counties in the United States (U.S.) in which more than 50 percent of new HIV diagnoses occur. There is an urgent need for innovative and collaborative new approaches to HIV treatment and prevention in adolescents and young adults (AYA) in Houston. The long-term goal of this research is to move the U.S. and Houston area closer to ending the HIV epidemic by addressing the issues involved in successful prevention and treatment of HIV in AYA. These goals align with Adolescent Trials Network (ATN) research objectives and Houston Consortium partnerships will allow research to be conducted in AYA in all five priority areas of the ATN: improving HIV testing, preventing new infections, engaging youth in care, improving treatment and treatment effectiveness, and reducing adverse HIV health outcomes due to COVID-19. We plan to accomplish the following specific aims as a site for HIV care, research, and prevention in AYA. Aim 1 – Conduct the Trials of the ATN as identified by the ATN Executive Committee (EC) and Scientific Leadership Committee (SLC): Baylor College of Medicine (BCM) ATN site has a longstanding research unit with staff with years of experience working with AYA, both in a clinical trials settings and in the community, who are living with HIV (LWH) or are at risk for HIV. Aim 2 – Participate in the Development of Trials: BCM's ATN Project Lead and staff have years of experience in development and conducting of clinical trials in AYA and so will work in collaboration with the ATN Operations and Collaborations Center (OCC) to develop and conduct the trials performed in the ATN. In addition, the BCM Youth Community Advisory Board, (YCAB), which has had members who have been active in the ATN Youth Advisory Council (YAC) and National CAB, Youth Experts and Advocates for Health (ATN-YEAH), will evaluate and provide input on developing studies and provide and enhance ideas for future studies. Aim 3 – Provide Innovation Regarding Successful Recruitment and Enrollment of Participants: As an ATN Site Consortium, we have the structure, experience, and outreach to approach this aim at multiple levels with outreach in hard-to- reach AYA including racial and gender minority and homeless youth. Aim 4 – Provide Sites (Texas Children's Hospital and Harris Health Northwest and Thomas Street Health Center) as well as outreach within the Houston ATN Consortium, local laboratory capacity, and pharmacy support in order to conduct the ATN trials in collaboration with the OCC. Aim 5 – Continued evaluation and adjustment of Houston collaborative consortium leadership model for meaningful and continued community engagement as reflected in ATN research study participation of AYA at risk for or LWH. We anticipate the expected outcomes of improvements in each ATN priority area along the continuums of HIV infection and prevention. This project is high impact because it will provide the necessary consortium in impacted communities of AYA in a high-priority region of the U.S. to collaborate with the OCC to make sustainable progress in reaching the ATN goals.

摘要贝勒医学院 包括休斯顿市在内的哈里斯县（Harris County）是美国（美国）的48个县之一 超过50％的新艾滋病毒诊断发生了。迫切需要创新和 青少年和年轻人（AYA）的艾滋病毒治疗和预防艾滋病毒治疗的新方法（aya） 休斯顿。这项研究的长期目标是使美国和休斯顿地区更接近结束艾滋病毒 通过解决AYA中成功预防和治疗HIV的问题，通过解决流行病。这些目标 与青少年试验网络（ATN）研究目标保持一致，休斯顿联盟伙伴关系将 允许在ATN的所有五个优先领域在AYA进行研究：改善HIV测试，防止 新的感染，吸引青年参与护理，提高治疗和治疗效果以及降低 不良艾滋病毒的健康结果是由于19.19。我们计划实现以下特定目标作为网站 AYA中的HIV护理，研究和预防。 AIM 1 - 进行ATN确定的ATN试验 执行委员会（EC）和科学领导委员会（SLC）：贝勒医学院（BCM） ATN网站拥有一个长期的研究单位，员工拥有多年的AYA经验，都在 临床试验环境以及患有艾滋病毒（LWH）或有艾滋病毒风险的社区中。目标2 - 参加试验的开发：BCM的ATN项目负责人和员工拥有多年的经验 在AYA中开发和进行临床试验，因此将与ATN操作合作合作 和合作中心（OCC）开发和进行ATN中执行的试验。此外，BCM 青年社区顾问委员会（YCAB），有活跃于ATN青年的成员 咨询委员会（YAC）和国家出租车，青年专家和卫生倡导者（ATN-YEAH）将评估 并提供有关开发研究的意见，并为未来的研究提供和增强思想。 AIM 3 - 提供 关于成功招募和参与者入学的创新：作为ATN网站财团，我们 拥有结构，经验和宣传，以实现这一目标，以实现多个层次 到达包括种族和性别少数和无家可归的青年在内的艾雅。 AIM 4 - 提供网站（德克萨斯州儿童） 医院和Harris Health Northwest和Thomas Street Health Center）以及外展 休斯顿ATN财团，地方实验室能力和药房支持，以进行ATN试验 与OCC合作。目标5 - 休斯顿合作的持续评估和调整 ATN反映的有意义和持续社区参与的财团领导力模型 AYA有风险或LWH的研究研究参与。我们预计改进的预期结果 在每个ATN的优先区域，沿着HIV感染和预防的连续体。这个项目是高影响力 因为它将在AYA的受影响社区中提供必要的财团 美国与OCC合作，在达到ATN目标方面取得了可持续的进步。