Baylor College of Medicine Adolescent Medicine Trials Unit

贝勒医学院青少年医学试验单位

基本信息

批准号：
8811024
负责人：
MARY E PAUL
金额：
$ 42.27万
依托单位：
BAYLOR COLLEGE OF MEDICINE
依托单位国家：
美国
项目类别：
财政年份：
2011
资助国家：
美国
起止时间：
2011-04-07 至 2017-02-28
项目状态：
已结题

来源：
https://reporter.nih.gov/project-details/8811024
关键词：
AIDS prevention AIDS/HIV problem Acquired Immunodeficiency Syndrome Adherence Adolescent Adolescent Medicine Adolescent Medicine Trials Network Adolescent and Young Adult Age-Years Anti-Retroviral Agents Antidepressive Agents Area Behavioral Behavioral Research Caring Cities Clinic Clinic Visits Clinical Collaborations Communities County Drug Kinetics Enrollment Event HIV HIV Infections HIV-infected adolescents Health Home environment Hypersensitivity Immunology Intervention Intervention Trial Lead Medical Medically Underserved Area Medicine Needs Assessment Online Systems Patients Pediatric Hospitals Pharmaceutical Preparations Primary Prevention Principal Investigator Public Health Publishing Regimen Request for Applications Research Research Personnel Resources Retrovirology Risk Risk Reduction Safe Sex Secondary Prevention Structure Technology Teenagers Testing Texas Therapeutic Therapeutic Trials United States Youth antiretroviral therapy base behavioral study clinical research site college community organizations design experience improved innovation interactive multimedia meetings outreach pediatric department programs psychosocial research study response sexually active skills training tertiary prevention theories therapy adherence transmission process trial design

项目摘要

DESCRIPTION (provided by applicant): Baylor College of Medicine (BCM) is applying for an Adolescent Medicine Trials Unit (ATU) in response to NIH RFA-HD-10-015 Adolescent Medicine Trials Network for HIV/AIDS Interventions. The BCM Trials Unit plans to contribute to the ATN's research agenda by providing an experienced research team to plan, enroll, analyze and publish results of research trials including behavioral research studies, community needs assessments, and therapeutic trials while meeting clinical and behavioral needs of HIV-infected youth. The BCM ATU will have three resources of patients: 1) Teen Clinics for HIV-infected youth at Texas Children's Hospital (TCH) lead by Drs Paul and Schwarzwald, Sections of Allergy and Immunology, and Retrovirology respectively, Department of Pediatrics, BCM; 2) Thomas Street Clinic (TSC) HIV-infected youth clinic lead by Dr Schwarzwald; and 3) Project Medical Home Clinics which provide adolescent care in medically underserved areas of Houston lead by Dr Desiree Evans, Department of Pediatrics, BCM. BCM will have 225 HIV-infected adolescents and over 1000 at-risk adolescents who are 12-24 years of age available to approach for enrollment into intervention trials aimed at the prevention of HIV, primary prevention In at-risk and secondary and tertiary prevention in the HIV-infected, pre-adolescents, adolescents, and young adults. BCM proposes unique studies involving innovative use of technology for secondary prevention of HIV transmission and adherence to HIV medication regimens among youth, a study of the pharmacokinetics to evaluate interactions of antidepressants when used with antiretroviral medications in HIV-infected youth, and a study that evaluates linkage to care for youth identified as HIV-infected through a large, youth oriented community testing event sponsored by the city health department and a community based AIDS organization. BCM ATU has the clinical, behavioral and research capacities and linkages to community to participate in multiple trials aimed at prevention of HIV in youth and trials aimed at improvements in management and psychosocial functioning of HIV-infected youth. RELEVANCE: Youth in Houston and surrounding counties have one of the fastest growing rates of HIV-infection in the United States. Baylor College of Medicine (BCM)'s application to become an Adolescent Medicine Trials Unit is relevant to public health in that BCM plans to implement trials designed to promote primary prevention in HIV at-risk and secondary and tertiary prevention in HIV-infected youth.

描述（由申请人提供）：贝勒医学院 (BCM) 正在申请青少年医学试验单位 (ATU)，以响应 NIH RFA-HD-10-015 HIV/AIDS 干预青少年医学试验网络。 BCM 试验部门计划通过提供经验丰富的研究团队来规划、招募、分析和发布研究试验结果（包括行为研究、社区需求评估和治疗试验），同时满足 HIV 的临床和行为需求，从而为 ATN 的研究议程做出贡献-受感染的青少年。 BCM ATU 将拥有三种患者资源： 1) 德克萨斯儿童医院 (TCH) 的青少年诊所，由 Paul 和 Schwarzwald 博士领导，分别是 BCM 儿科的过敏和免疫学科以及逆转录病毒学科； 2) Thomas Street Clinic (TSC) 艾滋病毒感染青少年诊所，由 Schwarzwald 博士领导； 3) 医疗家庭诊所项目，由 BCM 儿科 Desiree Evans 博士领导，为休斯顿医疗服务匮乏的地区提供青少年护理。 BCM 将有 225 名 HIV 感染青少年和 1000 多名 12-24 岁的高危青少年可以参加旨在预防 HIV 的干预试验、一级预防以及二级和三级预防HIV 感染者、青春期前儿童、青少年和年轻人。 BCM 提出了独特的研究，涉及创新性地使用技术来二级预防 HIV 传播和青少年遵守 HIV 药物治疗方案，一项药代动力学研究，以评估抗抑郁药与抗逆转录病毒药物在 HIV 感染青少年中使用时的相互作用，以及一项评估通过由市卫生部门和社区艾滋病组织主办的大型、面向青年的社区检测活动，与对被确定感染艾滋病毒的青年的护理联系起来。 BCM ATU 拥有临床、行为和研究能力以及与社区的联系，可以参与多项旨在预防青少年艾滋病毒的试验以及旨在改善艾滋病毒感染青少年的管理和社会心理功能的试验。相关性：休斯顿及周边县的青少年是美国艾滋病毒感染率增长最快的县之一。贝勒医学院 (BCM) 申请成为青少年医学试验单位，这与公共卫生相关，因为 BCM 计划实施旨在促进艾滋病毒高危青少年的一级预防以及艾滋病毒感染青少年的二级和三级预防的试验。