Baylor College of Medicine Adolescent Medicine Trials Unit

贝勒医学院青少年医学试验单位

• 批准号: 8440209
• 负责人: MARY E PAUL
• 金额: $ 34.51万
• 依托单位: BAYLOR COLLEGE OF MEDICINE
• 依托单位国家: 美国
• 财政年份: 2011
• 资助国家: 美国
• 起止时间: 2011-04-07 至 2016-02-29
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/8440209
• 关键词: AIDS prevention; AIDS/HIV problem; Acquired Immunodeficiency Syndrome; Adherence; Adolescent; Adolescent Medicine; Adolescent Medicine Trials Network; Age-Years; Anti-Retroviral Agents; Antidepressive Agents; Area; Behavioral; Behavioral Research; Caring; Cities; Clinic; Clinic Visits; Clinical; Clinical Trials Design; Collaborations; Communities; County; Drug Kinetics; Enrollment; Event; HIV; HIV Infections; Health; Home environment; Hypersensitivity; Immunology; Intervention; Intervention Trial; Lead; Medical; Medically Underserved Area; Medicine; Needs Assessment; Online Systems; Patients; Pediatric Hospitals; Pharmaceutical Preparations; Primary Prevention; Principal Investigator; Public Health; Publishing; Regimen; Request for Applications; Research; Research Personnel; Resources; Retrovirology; Risk; Risk Reduction; Safe Sex; Secondary Prevention; Structure; Technology; Teenagers; Testing; Texas; Therapeutic; Therapy Clinical Trials; United States; Youth; antiretroviral therapy; base; clinical research site; college; community organizations; design; experience; improved; innovation; interactive multimedia; meetings; outreach; pediatric department; programs; psychosocial; research study; response; sexually active; skills training; tertiary prevention; theories; therapy adherence; transmission process; young adult

DESCRIPTION (provided by applicant): Baylor College of Medicine (BCM) is applying for an Adolescent Medicine Trials Unit (ATU) in response to NIH RFA-HD-10-015 Adolescent Medicine Trials Network for HIV/AIDS Interventions. The BCM Trials Unit plans to contribute to the ATN's research agenda by providing an experienced research team to plan, enroll, analyze and publish results of research trials including behavioral research studies, community needs assessments, and therapeutic trials while meeting clinical and behavioral needs of HIV-infected youth. The BCM ATU will have three resources of patients: 1) Teen Clinics for HIV-infected youth at Texas Children's Hospital (TCH) lead by Drs Paul and Schwarzwald, Sections of Allergy and Immunology, and Retrovirology respectively, Department of Pediatrics, BCM; 2) Thomas Street Clinic (TSC) HIV-infected youth clinic lead by Dr Schwarzwald; and 3) Project Medical Home Clinics which provide adolescent care in medically underserved areas of Houston lead by Dr Desiree Evans, Department of Pediatrics, BCM. BCM will have 225 HIV-infected adolescents and over 1000 at-risk adolescents who are 12-24 years of age available to approach for enrollment into intervention trials aimed at the prevention of HIV, primary prevention In at-risk and secondary and tertiary prevention in the HIV-infected, pre-adolescents, adolescents, and young adults. BCM proposes unique studies involving innovative use of technology for secondary prevention of HIV transmission and adherence to HIV medication regimens among youth, a study of the pharmacokinetics to evaluate interactions of antidepressants when used with antiretroviral medications in HIV-infected youth, and a study that evaluates linkage to care for youth identified as HIV-infected through a large, youth oriented community testing event sponsored by the city health department and a community based AIDS organization. BCM ATU has the clinical, behavioral and research capacities and linkages to community to participate in multiple trials aimed at prevention of HIV in youth and trials aimed at improvements in management and psychosocial functioning of HIV-infected youth. RELEVANCE: Youth in Houston and surrounding counties have one of the fastest growing rates of HIV-infection in the United States. Baylor College of Medicine (BCM)'s application to become an Adolescent Medicine Trials Unit is relevant to public health in that BCM plans to implement trials designed to promote primary prevention in HIV at-risk and secondary and tertiary prevention in HIV-infected youth.

描述（由申请人提供）：贝勒医学院（BCM）正在申请青少年医学试验部（ATU），以应对NIH RFA-HD-HD-10-015艾滋病毒/艾滋病干预措施的青少年医学试验网络。 BCM试验部门计划通过提供经验丰富的研究团队来计划，注册，分析和发布研究试验结果，包括行为研究，社区需求评估和治疗试验，同时满足感染HIV感染的HIV感染HIV的青年的临床和行为需求，从而为ATN的研究议程做出贡献。 BCM ATU将拥有三种患者的资源：1）由Paul和Schwarzwald博士领导的得克萨斯州儿童医院（TCH）的青少年诊所，分别是过敏和免疫学的部分，以及逆转录病毒学，分别是儿科学系； 2）托马斯街诊所（TSC）HIV感染了Schwarzwald博士的青年诊所负责人；和3）医疗诊所项目，该诊所在休斯顿的医疗服务不足的地区提供青少年护理，由BCM儿科学系Desiree Evans博士领导。 BCM将有225名HIV感染的青少年和1000多名处于危险的青少年，他们的年龄为12-24岁，可用于入学，以预防HIV，旨在预防HIV，高危和中等和第三次预防的主要预防HIV，在HIV感染的HIV，预科，预科，预科生，青少年，青少年，成年和年轻人中。 BCM提出了独特的研究，涉及技术在二次预防艾滋病毒传播和对艾滋病毒药物方案的二次预防中，对年轻人中的艾滋病毒药物方案，一项对药代动力学的研究，以评估与抗逆转录病毒药物在艾滋病毒感染的年轻人中使用抗逆转录病毒药物的相互作用，并通过对年轻人进行的互联网进行了互联网，以评估年轻人的研究，以评估较大的群体，以评估年轻人的互联网，这是一名较大的互联网，而这是一项较大的互联网，而这是一名较大的互联网，而这是一项较大的互联网，而这是一项较大的群体，而a抗体药物则是针对年轻人的互联网，而是一名抗性药物。卫生部门和社区艾滋病组织。 BCM ATU具有临床，行为和研究能力以及与社区的联系，以参与旨在预防青年和试验的多项试验，旨在改善艾滋病毒感染的青年的管理和心理社会功能。 相关性：休斯顿及周边县的青年是美国艾滋病毒感染率增长最快的速度之一。贝勒医学院（BCM）成为青少年医学试验部门的申请与公共卫生有关，BCM计划实施旨在促进HIV高风险和二级预防HIV感染的HIV感染青年的试验。