Resource and Service Section

资源与服务科

• 批准号: 10251357
• 负责人: Cathleen M Lutz
• 金额: $ 7.55万
• 依托单位: JACKSON LABORATORY
• 依托单位国家: 美国
• 财政年份: 2020
• 资助国家: 美国
• 起止时间: 2020-09-01 至 2025-08-31
• 项目状态: 未结题
• 来源: https://reporter.nih.gov/project-details/10251357
• 关键词: Archives; Awareness; Behavioral; Bioinformatics; Biological Markers; CRISPR/Cas technology; Client; Clinical Trials; Communities; Complement; Development; Disease; Disease model; Duchenne muscular dystrophy; Environment; Faculty; Fee-for-Service Plans; Feedback; Fees; Funding; Gene Expression; Generations; Goals; Hand; Histology; Hospitals; Individual; Infrastructure; Knockout Mice; Laboratory mice; Link; Liquid substance; Maintenance; Marketing; Microscopy; Mission; Modeling; Mus; Mutant Strains Mice; Patients; Pharmacology; Phenotype; Physiology; Preclinical Testing; Process; Production; Program Development; Rare Diseases; Reagent; Recording of previous events; Reporting; Research; Research Personnel; Resource Development; Resources; Sales; Service delivery model; Services; Spinal Muscular Atrophy; Structure; Technology; The Jackson Laboratory; Therapeutic; United States National Institutes of Health; Work; base; cost; data access; experience; genome editing; improved; mouse model; operation; outreach; precision genetics; preservation; programs; public repository; quality assurance; repository; service programs; somatic cell gene editing; tool; treatment center; user-friendly; web site

PROJECT SUMMARY RESOURCE AND SERVICE CORE The overall goal of the Resource & Service Core is to publicize the mice and services developed through the JCPG to the broader scientific community. To accomplish this goal, the Core will work closely with the Bioinformatics Core in the development of the JCPG website and portal to allow public access to resources and tools. The distribution of mice will leverage the existing mouse production infrastructure at The Jackson Laboratory (JAX) as well as the existing NIH-funded Mutant Mouse Resource and Research Center (MMRRC) for a seamless transition of models from the core to the community. The Core will add new services and refine existing service to ultimately develop into a fee for service program that operates in professional service environment, with customer quotes, project execution, deliverables, finalized reports and feedback. JAX has an almost 90-year history of developing, archiving, and distributing laboratory mice, and their derivative resources and information, to the scientific community. The JCPG will complement and expand resource stewardship at JAX by leveraging the deep expertise of JAX researchers and services. JAX is seeing a predictable demand for model generation services as a result of CRISPR/Cas9 genome editing technologies and the reduction in costs for patient sequencing. This, in turn, has increased the demand for phenotyping and ancillary services, such as histology, gene expression, microscopy, etc. that can be tailored for each disease model. Another growing demand that the JCPG will help to satisfy is the need for pharmacology and efficacy-based preclinical testing in mice. Operation of the JCPG Resource and Service Core will serve to: 1) Provide new mouse models to the scientific community, following well-established processes for, rigor, quality assurance and customer service. Mice generated by the Disease Modeling Unit (DMU) will pass seamlessly through our customer service and production infrastructure to the JAX-MMRRC repository for maintenance, distribution and preservation. Each step of the process will be facilitated by tools and processes developed by the Bioinformatics section of the JCPG. 2) Refine existing and consider new key JAX services with input from our clients and make them available to the biomedical community on a fee-based mechanism with a focus on maximizing awareness and external availability using existing JAX outreach and marketing infrastructure and efforts. 3) Develop an integrated management and operational structure that weaves together core services and delivers them as efficiently as possible. Successful implementation of the Resource/Services core depends on our experienced management team to integrate individual service cores into a seamless program.

项目摘要资源和服务核心 资源和服务核心的总体目标是宣传通过 JCPG向更广泛的科学界。为了实现这一目标，核心将与 JCPG网站和门户的开发中的生物信息学核心，允许公众访问资源 和工具。小鼠的分布将利用杰克逊现有的鼠标生产基础设施 实验室（JAX）以及现有的NIH资助的突变体资源和研究中心（MMRRC） 对于从核心到社区的模型无缝过渡。核心将添加新服务并完善 现有的服务，最终发展为服务计划的费用，该计划在专业服务中运作 环境，带有客户报价，项目执行，可交付成果，最终报告和反馈。 Jax拥有近90年的发展，存档和分发实验室小鼠及其 派生资源和信息，向科学界。 JCPG将补充并扩展 通过利用JAX研究人员和服务的深厚专业知识，在JAX的资源管理。 JAX看到CRISPR/CAS9基因组的模型生成服务的可预测需求 编辑技术和患者测序成本的降低。反过来，这增加了需求 用于表型和辅助服务，例如组织学，基因表达，显微镜等 为每个疾病模型量身定制。 JCPG将有助于满足的另一个不断增长的需求是需要 小鼠的药理学和基于功效的临床前测试。 JCPG资源和服务核心的操作将用于：1）为科学提供新的鼠标模型 社区遵循良好的流程，严格，质量保证和客户服务。老鼠 由疾病建模单元（DMU）生成的 JAX-MMRRC存储库维护，分配和保存的生产基础架构。每个 该过程的步骤将由“生物信息学部分”部分开发的工具和过程促进 JCPG。 2）完善现有的现有并考虑新的关键JAX服务，并通过我们的客户输入并制作它们 生物医学界以一种基于费用的机制提供，重点是提高意识和 使用现有的JAX外展和营销基础设施和努力的外部可用性。 3）开发一个 集成管理和运营结构，将核心服务编织在一起，并将其作为 尽可能有效。资源/服务核心的成功实施取决于我们经验丰富的 管理团队将单个服务核心集成到无缝计划中。