Special Mouse Strains Resource

特殊小鼠品系资源

• 批准号: 10645429
• 负责人: Cathleen M Lutz
• 金额: $ 41.01万
• 依托单位: JACKSON LABORATORY
• 依托单位国家: 美国
• 财政年份: 2022
• 资助国家: 美国
• 起止时间: 2022-07-01 至 2026-01-31
• 项目状态: 未结题
• 来源: https://reporter.nih.gov/project-details/10645429
• 关键词: Address; Animals; Archives; Biological; Biomedical Research; Breeding; Caring; Cells; Collaborations; Collection; Communities; Complex; Consomic Strain; DNA sequencing; Data; Derivation procedure; Development; Disease; Dissection; Ensure; Environmental Risk Factor; Epigenetic Process; Epistatic Gene; Faculty; Foundations; Funding; Future; Genes; Genetic; Genetic Drift; Genetic Engineering; Genetic Epistasis; Genetic Heterogeneity; Genetic Research; Genetic Variation; Genetic study; Genome; Genotype; Geography; Goals; Health; Health Status; Heritability; Human; Human Biology; Human Genetics; Inbred Strain; Inbreeding; Infrastructure; Institution; Investments; Laboratory mice; Leadership; Legal; Medical Records; Modeling; Mouse Strains; Mus; Phenotype; Physiological; Play; Population; Production; Quantitative Trait Loci; Quarantine; Recombinants; Reproducibility; Request for Proposals; Research; Research Personnel; Resources; Role; Sample Size; Ships; Source; Standardization; System; Technology; The Jackson Laboratory; Tissues; United States National Institutes of Health; Variant; Vendor; Work; biobank; cost; design; embryo cryopreservation; gene environment interaction; gene network; genetic manipulation; genetic resource; human disease; member; model design; outreach; personalized medicine; preservation; repository; sperm cell; tool; trait

PROJECT SUMMARY/ABSTRACT – Overall Component Many aspects of human health and disease are genetically complex; that is, they arise from multiple interactions between genetic, developmental, and environmental factors. Understanding this complexity is the basis of personalized medicine. Unfortunately, human genetic studies are still limited in a number of ways including inadequate, retrospective medical records, formidable sample size requirements, insufficient statistical power to study genetic interactions, and insufficient mechanistic information about many genes. These obstacles are easily addressed using non-human, mammalian models, such as mice, that are designed for fine scale dissection of genetic complexity, i.e. systems genetics. The biomedical research community has made a significant investment in the genetically diverse inbred strains and genetic reference populations of mice as tools for systems genetics research. This proposal requests ongoing support for The Special Mouse Strain Resource (SMSR) at The Jackson Laboratory. The SMSR serves as the biorepository for these unique sets of strains, ensuring permanent and open access from high health status, quality-controlled, state-of-the-art facilities. The resource currently consists of more than 300 strains, including the widely used BXD and Collaborative Cross strain panels, but importantly, the strains available in the SMSR are changed and developed as dictated by the needs of research community. The major activities of the SMSR are to: i) archive, maintain, and distribute these strains to qualified biomedical researchers, ii) provide complete, accurate and accessible information related to the mouse resources, iii) confer with an external advisory board of thought leaders from the complex trait community to define current and future resources, iv) provide leadership in best practices for research and reproducibility using SMSR resources. The SMSR also provides infrastructure, outreach and collaborative opportunities for the development of new tools for complex trait analysis, as well as access to existing strains and populations for large-scale multicenter projects; and conducts research to expand tools for genetic engineering of specialized mapping strains.

项目摘要/摘要 - 整体组件 人类健康和疾病的许多方面在遗传上很复杂。也就是说，它们来自多个 遗传，发育和环境因素之间的相互作用。了解这种复杂性是 个性化医学的基础。不幸的是，人类遗传研究仍然受到多种方式的限制 包括不足，回顾性病历，强大的样本量要求，不足 研究遗传相互作用的统计能力以及有关许多基因的机械信息不足。 这些障碍是使用设计的非人类哺乳动物模型（例如小鼠）轻松解决的。 对于遗传复杂性的精细规模解剖，即系统遗传学。生物医学研究界有 对遗传多样的近交菌株和遗传参考人群进行了大量投资 小鼠作为系统遗传学研究的工具。 该提案要求在杰克逊的特殊鼠标应变资源（SMSR）持续支持 实验室。 SMSR充当这些独特菌株集的生物库，确保永久性和 从高健康状况，质量控制，最先进的设施的开放访问。当前的资源 由300多种菌株组成，包括广泛使用的BXD和协作交叉应变板，但 重要的是，SMSR中可用的菌株按照需求而更改和开发 研究社区。 SMSR的主要活动是：i）存档，维护和分配这些菌株 研究人员，ii）提供与鼠标资源有关的完整，准确且可访问的信息，iii） 与复杂特质社区的外部思想领袖咨询委员会会议，以定义当前 和未来的资源，iv）使用SMSR提供研究和可重复性的最佳实践领导 资源。 SMSR还为开发新的基础架构，外展和协作机会 用于复杂性状分析的工具，以及访问大型多中心的现有菌株和人群 项目；并进行研究以扩大专门映射菌株基因工程的工具。