Coordination Section

协调科

• 批准号: 10469582
• 负责人: Cathleen M Lutz
• 金额: $ 20.08万
• 依托单位: JACKSON LABORATORY
• 依托单位国家: 美国
• 财政年份: 2020
• 资助国家: 美国
• 起止时间: 2020-09-01 至 2025-08-31
• 项目状态: 未结题
• 来源: https://reporter.nih.gov/project-details/10469582
• 关键词: Accounting; Achievement; Awareness; Bioinformatics; Clinical; Clinical Research; Clinical Trials Design; Communication; Communities; Consultations; Development; Disease; Disease model; Drug usage; Ensure; Evaluation; Foundations; Generations; Goals; Grant; Guidelines; Human Genetics; Human Resources; Infrastructure; Laboratories; Laboratory mice; Leadership; Letters; Marketing; Mission; Modeling; Monitor; Participant; Play; Procedures; Process; Production; Productivity; Program Reviews; Progress Reports; Publications; Recommendation; Records; Reporting; Research; Resource Development; Resources; Review Committee; Role; Schedule; Scientist; Services; Testing; The Jackson Laboratory; TimeLine; United States National Institutes of Health; Ursidae Family; Variant; base; drug testing; experience; genetic resource; genetic technology; genetic variant; innovation; meetings; member; model development; mouse model; multidisciplinary; operation; outreach; precision genetics; preclinical study; programs; recruit; synergism; tool; translational potential; web portal; web site; working group

PROJECT SUMMARY COORDINATION CORE The Jackson Laboratory (JAX) Center for Precision Genetics (JCPG) brings together a multi-disciplinary team including geneticists, genetics technology experts, quantitative and computational biologists, clinical experts and experienced resource managers. The purpose of the Coordination Core (hereafter, Core) is to ensure productive interactions among all participants and to oversee and facilitate all administrative and scientific functions of the JCPG. This function is carried out under the direction of the JCPG Director and the Program Manager in consultation with a Steering Committee (SC) and an External Advisory Board (EAB). Effective coordination of the JCPG will be achieved by accomplishing four Specific Aims: AIM 1. Optimize integration and function of JCPG activities through strong administrative and technical oversight. This includes: i) facilitating the process of nominating disease modeling projects, ii) ensuring integrated operation of the Bioinformatics core, the Disease Modeling Unit and the Pre/Co Clinical core, iii) facilitation of all internal and external JCPG communications, iv) coordination of activities of the SC and EAB and, v) coordinating production and submission of all JCPG records to meet internal and external reporting requirements. AIM 2. Promote center productivity and scientific synergy through effective communication. In this role the Core is responsible for organizing all formal meetings between and among JCPG leadership, advisors and external stakeholders. The purpose of all meetings is to track progress toward aims and milestones and will follow a regular schedule that will be supplemented with ad hoc gatherings as needed. AIM 3. Implement and refine a decision framework for evaluating and prioritizing variant nominations. A central function of the JCPG is to provide a public-facing process for nomination of human genetic variants that either have no existing mammalian research model or for which existing models are inadequate. The JCPG will establish a process that allows nominees to submit variant candidates through a JCPG web portal located on the JAX website (www.jax.org). These nominations will undergo a review process to evaluate feasibility, scientific and community need, and then prioritize the nomination for entry into the pipeline for model production. The JCPG Program Manager will communicate directly with the nominee throughout the process. AIM 4. Outreach and External Communication. The impact of the JCPG is directly related to the number of projects that are nominated and complete development. To maximize awareness for all potential entities that might need new mouse models for research and testing we will: i) leverage an existing extensive network of disease foundations and clinical partners to promote contacts with similar entities that might need mouse models and, ii) employ the extensive marketing and outreach infrastructure of JAX Mice, Clinical and Research Services (JMCRS) to bring worldwide awareness to JCPG activities, models, tools and services.

项目摘要协调核心 杰克逊实验室（JAX）精密遗传学中心（JCPG）汇集了一个多学科团队 包括遗传学家，遗传学技术专家，定量和计算生物学家，临床专家 和经验丰富的资源经理。协调核心的目的（以下为核心）是确保 所有参与者之间的生产互动，并监督和促进所有行政和科学 JCPG的功能。此功能是在JCPG主管和计划的指导下执行的 经理与指导委员会（SC）和外部顾问委员会（EAB）协商。 通过实现四个具体目标，将实现JCPG的有效协调： 目标1。通过强大的行政和 技术监督。这包括：i）促进提名疾病建模项目的过程，ii） 确保生物信息学核心，疾病建模单元和PE/CO临床的综合操作 核心，iii）促进所有内部和外部JCPG通信，iv）SC活动的协调 EAB和，V）协调所有JCPG记录的生产和提交，以满足内部和外部 报告要求。 目标2。通过有效的沟通来促进中心的生产率和科学协同作用。在这个角色中 核心负责组织JCPG领导，顾问和之间的所有正式会议 外部利益相关者。所有会议的目的是跟踪目标和里程碑的进度，并将 遵循常规时间表，该时间表将根据需要补充临时聚会。 目标3。实施并完善一个决策框架，以评估和优先考虑变体提名。 JCPG的核心功能是为提名人类遗传变异的公共面向公共过程 要么没有现有的哺乳动物研究模型，要么对现有模型不足。这 JCPG将建立一个过程，允许被提名人通过JCPG Web门户提交变体候选人 位于JAX网站（www.jax.org）上。这些提名将经历评估的审查程序 可行性，科学和社区需求，然后优先考虑进入模型管道的提名 生产。 JCPG计划经理将在整个过程中直接与提名人沟通。 目标4。外展和外部交流。 JCPG的影响与数量直接相关 被提名和完整发展的项目。最大化对所有潜在实体的认识 可能需要新的鼠标模型进行研究和测试，我们将：i）利用现有的广泛网络 疾病基础和临床伴侣，以促进与可能需要小鼠的类似实体的接触 模型和ii）采用JAX小鼠，临床和研究的广泛的营销和外展基础设施 服务（JMCR）为JCPG活动，模型，工具和服务带来全球认识。