Core A: Administrative Core

核心A：行政核心

• 批准号: 10555893
• 负责人: PHILIP L DE JAGER
• 金额: $ 67.09万
• 依托单位: COLUMBIA UNIVERSITY HEALTH SCIENCES
• 依托单位国家: 美国
• 财政年份: 2023
• 资助国家: 美国
• 起止时间: 2023-09-30 至 2028-08-31
• 项目状态: 未结题
• 来源: https://reporter.nih.gov/project-details/10555893
• 关键词: 3-Dimensional; Accounting; Achievement; Address; Aging; Alzheimer' s Disease; Alzheimer' s disease brain; Alzheimer' s disease pathology; Amyloid; Atlases; Autopsy; Awareness; Brain; Cells; Cerebral Amyloid Angiopathy; Charge; Collaborations; Committee Members; Communication; Communities; Complement; Computer Analysis; Data; Documentation; Education; Ensure; Environment; Event; Financial Activity; Freezing; Generations; Goals; Immunohistochemistry; Impaired cognition; Individual; Knowledge; Knowledge Portal; Laboratories; Leadership; Lewy Bodies; Management Information Systems; Measurement; Methodology; Methods; Molecular; National Institute on Aging; Neocortex; Participant; Pathology; Process; Production; Program Evaluation; Proteomics; Protocols documentation; Research; Research Project Grants; Resolution; Resource Sharing; Resources; Specimen; Structure; System; Techniques; Time; Tissues; United States National Institutes of Health; Visualization; Work; age effect; aging brain; brain tissue; cost; data hub; data integration; data quality; data reduction; data resource; design; experience; improved; insight; interest; meetings; molecular modeling; molecular phenotype; multidimensional data; multimodal data; multiple omics; neocortical; neuropathology; operation; program dissemination; programs; protein TDP-43; repository; research data dissemination; symposium; synergism; tau Proteins; transcriptomics; web site

ADMINISTRATIVE CORE: PROJECT SUMMARY/ABSTRACT The overall theme of the “3-D Aging & Alzheimer Brain Program” is to is to define the effect of multiple pathologies on the aged brain in three dimensions by combining single cell-based approaches with spatially-resolved transcriptomic and proteomic measurements. To accomplish this goal, the Program has been organized into four cores and four research projects, each with their own individual goals whose complexity and ultimate interconnection requires careful coordination and oversight. Central to this effort is the Administrative Core (Admin Core), which will serve as the organizational hub for our Program, providing an umbrella of scientific oversight, coordination, and support for the Program activities. The Admin Core will be led by the Program Director, Dr. Philip De Jager, who will be responsible for overseeing the day-to-day operations with support from a project coordinator and an administrative assistant. Together, they will provide support for administrative and financial activities, as well as manage all internal and external communications, including those with the National Institute on Aging (NIA). To ensure scientific oversight of the Program, the Director will chair the Steering Committee, which will be composed of Core and Project Co-Leads, as well as relevant NIH staff. The experience of the Steering Committee members will be leveraged to establish a Charter and to set attainable deliverables at the onset of the Program. Additionally, the Steering Committee will meet monthly to coordinate and ensure that the overall goals of the Program are being achieved. The Steering Committee will work closely with the NIA to assemble an External Advisory Board (EAB), which will annually evaluate the Program and provide external oversight. The Admin Core will develop and implement a state-of-the art Laboratory Information Management System (LIMS) to ensure appropriate tracking of specimens and data between the Program components. The Admin Core will also be responsible for ensuring compliance with the Program’s resource sharing plan in order to maximize access to the resources generated by the Program. This will be facilitated via a collaboration with Sage Bionetworks in order to oversee distribution of all Program data and resources via the NIA-sponsored repository, AD Knowledge Portal. The Admin Core will organize a quarterly educational meeting focused on the techniques and best practices implemented via this Program. To help promote awareness of Program resources and scientific activities, the Program will participate in and host an annual research symposium and establish an outward-facing website. The Admin Core is designed to provide research and logistical oversight and facilitate communication among all Program components to enhance efficiency, reduce cost, and maintain the timely achievement of milestones. The proper dissemination of Program-generated resources to the scientific community will fill the large gap in knowledge regarding the 3-dimensional modeling of molecular events in the aging brain and the impact of neuropathological features.

行政核心：项目摘要/摘要 “ 3-D老化和阿尔茨海默氏症脑计划”的总体主题是定义多种病理的影响 通过将单细胞的方法与空间分辨的，在三个维度的老化大脑上 转录组和蛋白质组学测量。为了实现这一目标，该计划已组织成四个 核心和四个研究项目，每个项目都有自己的个人目标，其复杂性和最终 互连需要仔细的协调和监督。这项工作的核心是行政核心 （Admin Core）将作为我们计划的组织中心，提供科学的伞 对计划活动的监督，协调和支持。管理员核心将由程序领导 董事，菲利普·德·贾格（Philip de Jager）博士，他将在下来负责监督日常运营的情况下 项目协调员和行政助理。他们将共同为行政和 财务活动以及管理所有内部和外部沟通，包括国家 老化研究所（NIA）。为了确保对该计划的科学监督，主任将主持转向 委员会将由核心和项目共同领导者以及相关的NIH工作人员组成。经验 指导委员会成员将被利用以建立宪章并设置可实现的交付 在程序开始时。此外，指导委员会将每月开会以协调并确保 该计划的总体目标正在实现。指导委员会将与NIA紧密合作 组装外部咨询委员会（EAB），该委员会每年都会评估该计划并提供外部 监督。管理员核心将开发和实施最先进的实验室信息管理 系统（LIMS），以确保适当跟踪程序组件之间的标本和数据。这 管理员核心还将负责确保遵守该计划的资源共享计划 为了最大程度地访问程序生成的资源。这将通过与 Sage Bionetworks是为了通过NIA赞助的所有程序数据和资源的海外分发 存储库，广告知识门户。管理员核心将组织一次季度教育会议，重点是 通过此程序实施的技术和最佳实践。帮助提高对计划资源的认识 和科学活动，该计划将参加并举办年度研究研讨会，并建立一个 面向外向网站。管理员核心旨在提供研究和后勤监督和准备 所有程序组件之间的沟通以提高效率，降低成本并保持及时 实现里程碑。将程序生成的资源的适当传播给科学 社区将填补有关分子事件三维建模的知识的巨大差距 大脑衰老和神经病理学特征的影响。