Neuroimmunology Core

神经免疫学核心

基本信息

批准号：
10668280
负责人：
PHILIP L DE JAGER
金额：
$ 17.92万
依托单位：
COLUMBIA UNIVERSITY HEALTH SCIENCES
依托单位国家：
美国
项目类别：
财政年份：
2020
资助国家：
美国
起止时间：
2020-06-15 至 2025-04-30
项目状态：
未结题

来源：
https://reporter.nih.gov/project-details/10668280
关键词：
Acceleration Activities of Daily Living Alzheimer&apos s Disease Antibodies Antigens Area Astrocytes Biological Assay Biological Markers Biological Models Budgets Cells Cerebrospinal Fluid Clinical Cognitive Collaborations Collection Communities Cryopreservation Data Databases Development Disease Education Evaluation Family Future Genetic Genetic Transcription Genetic study Human Immune Immune response Immune system Immunotherapy Individual Infiltration Inflammation Innate Immune System Investigation Leucocytic infiltrate Measures Mediating Mendelian randomization Microglia Minor Molecular Morphology Myeloid Cells Participant Pathogenicity Pathologic Pathology Pathway interactions Patients Peripheral Peripheral Blood Mononuclear Cell Phagocytes Play Population Predisposition Process Proteins Proteome Proxy Research Research Design Research Personnel Resources Role Sampling Science Stimulus Structure Surrogate Markers Testing Universities age related biobank cell bank data exchange data resource design endophenotype glial activation immune function monocyte neuroimaging neuroimmunology novel prevent programs recruit response transcriptome transcriptome sequencing

Acceleration Activities of Daily Living Alzheimer&apos s Disease Antibodies Antigens Area Astrocytes Biological Assay Biological Markers Biological Models Budgets Cells Cerebrospinal Fluid Clinical Cognitive Collaborations Collection Communities Cryopreservation Data Databases Development Disease Education Evaluation Family Future Genetic Genetic Transcription Genetic study Human Immune Immune response Immune system Immunotherapy Individual Infiltration Inflammation Innate Immune System Investigation Leucocytic infiltrate Measures Mediating Mendelian randomization Microglia Minor Molecular Morphology Myeloid Cells Participant Pathogenicity Pathologic Pathology Pathway interactions Patients Peripheral Peripheral Blood Mononuclear Cell Phagocytes Play Population Predisposition Process Proteins Proteome Proxy Research Research Design Research Personnel Resources Role Sampling Science Stimulus Structure Surrogate Markers Testing Universities age related biobank cell bank data exchange data resource design endophenotype glial activation immune function monocyte neuroimaging neuroimmunology novel prevent programs recruit response transcriptome transcriptome sequencing

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项目摘要

NEUROIMMUNOLOGY CORE PROJECT SUMMARY/ABSTRACT The Columbia University ADRC’s Neuroimmunology (Neuroimm) Core supports the development of biosample and data resources along one of the three thematic axes of the ADRC. Characterizing immune responses is an important component of AD investigations, but these responses are not solely responsible for the disease. Thus, it is important to integrate thoughtful, informed study design, specialized resources as well as emerging experimental and analytic pipelines for systematic immune function characterization with existing biomarker, genetic, neuroimaging and other resources to assemble a comprehensive approach to AD investigations. Our understanding of the role of the immune system in AD is rapidly evolving, and innate immune cells appear to play a key role. Thus, we propose to: (1) create a new sample resource by cryopreserving CSF cells from each recruited subject, (2) create new assays that measure surrogate markers of microglia in CSF, (3) assess the systemic state of inflammation in each of the sampled subjects, and (4) estimate the functional capacity of each individual’s microglia to respond to key stimuli. Thus, we will generate novel sample, assay, and data resources with which to accelerate the characterization of the immune system in AD.

神经免疫学核心项目摘要/摘要哥伦比亚大学ADRC的神经免疫学（NEUROIMM）核心支持发展沿ADRC的三个主题轴之一的生物样本和数据资源。表征免疫响应是广告调查的重要组成部分，但这些响应并不完全负责疾病。这一点，重要的是整合周到的，知情的研究设计，专业资源以及新兴的实验和分析管道，用于系统的免疫功能表征，现有生物标志物，遗传，神经影像和其他资源，以组装全面的广告方法调查。我们对免疫系统在AD中的作用的理解正在迅速发展，先天免疫细胞似乎起着关键作用。那就是我们建议：（1）通过冷冻率CSF创建一个新的样本资源来自每个招募受试者的细胞，（2）创建新的测定法，以测量CSF中小胶质细胞的替代标记，（3）评估每个采样受试者的系统性炎症状态，（4）估计功能每个人的小胶质细胞能够应对关键刺激的能力。那我们将生成新颖的样本，分析，以及可以加速AD中免疫系统表征的数据资源。