Special Mouse Strains Resource

特殊小鼠品系资源

基本信息

批准号：
10400461
负责人：
Cathleen M Lutz
金额：
$ 46.72万
依托单位：
JACKSON LABORATORY
依托单位国家：
美国
项目类别：
财政年份：
2021
资助国家：
美国
起止时间：
2021-07-01 至 2025-01-31
项目状态：
未结题

来源：
https://reporter.nih.gov/project-details/10400461
关键词：
2019-nCoV ACE2 Address Affect Animal Model Animals Autoimmune Biomedical Research Body Weight COVID-19 Communities Complex DNA sequencing Data Disease Outbreaks Drug or chemical Tissue Distribution Embryo Transfer Exposure to Feces Fertilization in Vitro Gap Junctions Genetic Genetic Variation Genetic study Genome Goals Grant Health Histologic Horizontal Disease Transmission Human Human Genetics Inbred Mouse Inbred Strain Inbreeding Infection Intervention K-18 conjugate Kidney Kinetics Knowledge Laboratory mice Lead Leadership Liver Lung Modeling Monitor Mouse Strains Mus Mutation Pathogenesis Phenotype Policies Population Predisposition Reporting Reproducibility Research Research Infrastructure Resources Reverse Transcriptase Polymerase Chain Reaction SARS-CoV-2 B.1.351 SARS-CoV-2 variant Sampling Sentinel Sexual Reproduction Source South African Spleen Standardization Surveys System Technology Testing The Jackson Laboratory Therapeutic Tissues Transgenic Animals Variant Viral Viral Load result Virus Zoonoses cohort design genetic variant human disease improved infection management insight interest male medical specialties mouse model prevent reproductive organ respiratory response sperm cell transmission process variants of concern viral genomics

项目摘要

Abstract Understanding the effects of genetic diversity on human disease is the nexus of the Specialty Mouse Strains Resource (SMSR) grants. Recent findings that SARS-CoV-2 variants of concern (VOCs) can infect common laboratory mice creates both and opportunity and a concern. The concern is that SARS-CoV-2 has become a zoonotic agent that will impact research using mice. Little is known about how these VOCs will affect laboratory mice, whether mouse-to-mouse transmission is possible, or how to survey vivaria for infection. It is critical that we understand the course of infection, pathogenesis, and transmissibility including through germplasm so that strategies can be developed to protect research that depends on the use of mice. The data generated through this proposal will address these gaps in knowledge and will be of value to those developing policies and practices to prevent or manage outbreaks, protecting the research resources and infrastructure utilizing mice Paradoxically, the infection of VOCs in inbred mice also presents an opportunity. The differential infection among inbred strains for VOCs outlined in this proposal will increase our knowledge of host genetics of infection, providing a tremendous opportunity to improve our overall strategies in the design and use of mouse models for SARS-CoV-2, towards the ultimate goal of testing interventions and therapeutics.

抽象的了解遗传多样性对人类疾病的影响是专业的联系小鼠应变资源（SMSR）赠款。最近发现的SARS-COV-2变体的发现（VOC）可以感染普通实验室小鼠会产生和机会和关注。这担心的是SARS-COV-2已成为一种人畜共患剂，它将使用小鼠影响研究。对于这些VOC如何影响实验室小鼠，无论是鼠标到鼠标，是否知之甚少可以传播，或如何调查Vivaria感染。我们了解感染过程，发病机理和可传播性，包括通过种质，以便可以制定策略来保护取决于小鼠使用的研究。数据通过该提案生成的将解决这些知识的差距，将是有价值的那些制定政策和实践来预防或管理爆发，保护研究利用小鼠的资源和基础设施自相矛盾的是，近交小鼠中VOC的感染也带来了机会。差异在此提案中概述的VOC的近交菌株中的感染将增加我们对宿主感染的遗传学，提供了一个巨大的机会来改善我们的整体策略 SARS-COV-2的鼠标模型的设计和使用，实现了测试的最终目标干预和治疗学。