Administrative Core

行政核心

• 批准号: 10668763
• 负责人: Cathleen M Lutz
• 金额: $ 23.51万
• 依托单位: JACKSON LABORATORY
• 依托单位国家: 美国
• 财政年份: 2023
• 资助国家: 美国
• 起止时间: 2023-05-16 至 2028-04-30
• 项目状态: 未结题
• 来源: https://reporter.nih.gov/project-details/10668763
• 关键词: Achievement; Animal Model; Animal Testing; Characteristics; Clinic; Clinical; Collaborations; Communication; Data; Data Collection; Discipline; Ensure; Face; Fostering; Funding; Goals; Institution; Lead; Leadership; Learning; Monitor; Neurodegenerative Disorders; Phase; Protocols documentation; Qualifying; Reagent; Reporting; Research; Research Personnel; Research Project Grants; Resource Sharing; Resources; Schedule; Science; Structure; Training and Education; Translations; United States National Institutes of Health; Work; data harmonization; data integration; data sharing; experience; genome editing; human disease; human model; improved; meetings; multidisciplinary; nervous system disorder; pre-clinical; precision genetics; programs; somatic cell gene editing; success; synergism; tool

SUMMARY ADMINISTRATIVE CORE Collaborative science faces unique challenges that parallel the size and scope of the project or Program. Beyond increased scientific challenges (such as data integration and harmonization), so too do the challenges to coordinate, communicate, and collaborate effectively within the Program increase. The proposed project includes four major research projects, supported by three resource cores, executed by a diverse multi-disciplinary team distributed across five research institutions. The goal of this Administrative (Admin) Core is to facilitate their coordination, communication, and collaboration. Our leadership team has extensive experience coordinating and managing large, multi-investigator programs; most notably as a small animal testing center in Somatic Cell Genome Editing (SCGE) Phase I funding, and as a precision genetics center (JAX Center for Precision Genetics, JCPG) improving animal models of human disease and move them towards translation to the clinic. In each of these programs, we have established frameworks for organizing our teams, sharing information across projects and institutions, tracking progress and milestones, and communicating progress to key stakeholders as well as the NIH program officers. Our previous experience leading Administration/Coordination Cores for multi- institutional, NIH-funded Programs makes us uniquely qualified to develop and execute on the administrative goals of this U19. The Admin Core will provide managerial and administrative structure for this U19 Program through the following Aims. In Aim 1 we establish an effective administrative governance structure to assure success of this U19 Program. We use prior experience and Program-specific characteristics to build a clear hierarchy of governance and include guidance from clinical experts in neurodegenerative diseases to hasten IND application. In Aim 2 we develop a formal meeting schedule to foster the communication needed to execute on the goals of this proposal. The Admin Core will be responsible for managing this schedule, recording, and reporting out on the progress and action items identified in these meetings. The Admin Core will use these reports to monitor progress toward milestones of the Program and each Project for Aim 3, assisting NIH Program officials in their alignment of our Program with SCGE Phase II. Finally, the Admin Core will communicate the findings from this U19 Program with the Translational Coordination and Dissemination Center for external distribution and assist in the creation of a shared learning and training education hub.

摘要行政核心 协作科学面临的独特挑战与项目或计划的规模和范围平行。超过 加大科学挑战（例如数据集成和协调），挑战也是如此 在计划中有效地协调，交流和协作。拟议的项目包括 由三个资源核心支持的四个主要研究项目由多元化的多学科团队执行 分布在五个研究机构中。此行政（管理）核心的目标是促进他们的 协调，沟通和协作。我们的领导团队拥有丰富的协调经验和 管理大型的多启示程序程序；最著名的是在体细胞中的小动物测试中心 基因组编辑（SCGE）I期资金，作为精确遗传学中心（JAX精确遗传学中心， JCPG）改善人类疾病的动物模型，并将其转化为诊所。在每个 这些计划，我们建立了用于组织团队的框架，在项目中共享信息 以及机构，跟踪进度和里程碑，以及将进度传达给主要利益相关者以及 NIH计划官员。我们以前的经验领导管理/协调核心 机构，NIH资助的计划使我们具有独特的资格来开发和执行管理 这个U19的目标。管理员核心将为此U19程序提供管理和管理结构 通过以下目标。在目标1中，我们建立了有效的行政治理结构以确保 这个U19程序的成功。我们使用先前的经验和特定计划的特征来建立清晰的 治理等级制度，包括神经退行性疾病的临床专家的指导 IND申请。在AIM 2中，我们制定了正式的会议时间表，以促进执行所需的沟通 关于该提议的目标。管理员核心将负责管理此时间表，记录和 报告这些会议中确定的进度和行动项目。管理员核心将使用这些 报告监视该计划的里程碑的进度和每个目标3的进度，协助NIH计划 官员们在我们计划与SCGE II阶段保持一致。最后，管理员核心将传达 该U19计划的调查结果与外部的翻译协调和传播中心 分发和协助创建共享的学习和培训教育中心。