Advanced Mass Spectrometry Facility

先进的质谱设备

• 批准号: 10264685
• 负责人: David Anderson
• 金额: $ 143.04万
• 依托单位: NATIONAL INSTITUTE OF DIABETES AND DIGESTIVE AND KIDNEY DISEASES
• 依托单位国家: 美国
• 资助国家: 美国
• 起止时间: 至
• 项目状态: 未结题
• 来源: https://reporter.nih.gov/project-details/10264685
• 关键词: Adopted; Annual Reports; Area; Back; Biological; Biopolymers; Calibration; Communities; Complex; Core Facility; Cost Effectiveness Analysis; Data; Data Analyses; Extramural Activities; Federal Government; Home environment; Label; Mass Spectrum Analysis; Measurement; Measures; Methodology; Molecular; Molecular Structure; Molecular Weight; National Institute of Allergy and Infectious Disease; National Institute of Diabetes and Digestive and Kidney Diseases; National Institute of Drug Abuse; Natural Products; Outsourcing; Peptide Fragments; Philosophy; Play; Problem Solving; Proteins; Quality Control; Research; Research Project Grants; Resolution; Resources; Rice; Role; Running; Sampling; Science; Software Tools; Structure; Synthesis Chemistry; System; Techniques; Time; Update; Work; coronavirus disease; crosslink; dalton; experience; experimental study; improved; instrument; macromolecule; mass spectrometer; novel strategies; protein complex; small molecule; tool

Historically the facility has supported on the order of 40 PIs each year involved with around 70 annual report level projects with around two-thirds of these projects coming from the NIDDK. Although useful metrics for some things, the PI-count and project-count are oversimplifications. It is important to note that the amount of support provided to each project varies widely. For instance, support of small molecule chemists at NIDDK and a number of projects involving biopolymer analysis at NIDDK were very involved while most of the support provided to non-NIDDK labs involved one or two low staff time experiments. Support of Kenner Rice (NIDA) is a special case as he only recently moved to NIDA from NIDDK and has had a long-standing working relationship with the facility in all its historical forms. In addition to working in direct support of PI projects staff and resources are used to update methodology, adopting new and proven approaches of clear importance to the NIDDK PI community and in a limited number of cases developing new approaches when these are of immediate importance to on-going PI projects and otherwise consistent with the facilitys technical philosophies. In the first four months of FY2020 we carried out normal support activities up to the stay-at-home order. Remote projects during the stay-at-home order included evaluating approaches toward improving the quality control of DSSO cross-linking analysis. John Lloyd was soon back half day twice a week supporting small molecule (and whole protein) measurements of various COVID projects. D. Eric Anderson retuned full time in group A and, in addition to normal project work, has supported approved COVID projects from NIDDK and NIAID.

从历史上看，该机构每年支持大约 40 个 PI，涉及约 70 个年度报告级别的项目，其中约三分之二的项目来自 NIDDK。 尽管 PI 计数和项目计数对于某些事情来说是有用的指标，但过于简单化了。值得注意的是，为每个项目提供的支持金额差异很大。例如，对 NIDDK 小分子化学家的支持以及 NIDDK 涉及生物聚合物分析的许多项目都参与其中，而向非 NIDDK 实验室提供的大部分支持则涉及一到两个低人员时间实验。 Kenner Rice (NIDA) 的支持是一个特例，因为他最近才从 NIDDK 转到 NIDA，并且与该机构以各种历史形式建立了长期的工作关系。 除了直接支持 PI 项目外，工作人员和资源还用于更新方法，采用对 NIDDK PI 社区具有明确重要性的新的和经过验证的方法，并在有限的情况下开发新方法，当这些方法对-正在进行的 PI 项目以及其他与设施技术理念一致的项目。 在 2020 财年的前四个月，我们开展了正常的支持活动，直至居家令为止。居家令期间的远程项目包括评估改进 DSSO 交联分析质量控制的方法。约翰·劳埃德 (John Lloyd) 很快每周两次返回半天岗位，支持各种新冠肺炎项目的小分子（和整个蛋白质）测量。 D. Eric Anderson 全职回归 A 组，除了正常的项目工作外，还支持 NIDDK 和 NIAID 批准的新冠病毒项目。