Advanced Mass Spectrometry Facility

先进的质谱设备

• 批准号: 8741641
• 负责人: David Anderson
• 金额: $ 178.26万
• 依托单位: NATIONAL INSTITUTE OF DIABETES AND DIGESTIVE AND KIDNEY DISEASES
• 依托单位国家: 美国
• 资助国家: 美国
• 起止时间: 至
• 项目状态: 未结题
• 来源: https://reporter.nih.gov/project-details/8741641
• 关键词: Adopted; Annual Reports; Area; Biological; Biological Factors; Biopolymers; Calibration; Communities; Complex; Core Facility; Data; Data Analyses; Federal Government; Label; Mass Spectrum Analysis; Measurement; Measures; Methodology; Metric; Molecular; Molecular Structure; Molecular Weight; National Institute of Diabetes and Digestive and Kidney Diseases; National Institute of Drug Abuse; Peptide Fragments; Philosophy; Play; Problem Solving; Proteins; Research; Research Project Grants; Resolution; Resources; Rice; Role; Running; Sampling; Science; Software Tools; Solutions; Structure; Synthesis Chemistry; System; Techniques; Time; Update; Work; crosslink; dalton; experience; instrument; interest; macromolecule; mass spectrometer; novel strategies; protein complex; research study; small molecule; tool

Historically the facility has supported on the order of 40 PIs each year involved with around 70 annual report level projects with around two-thirds of these projects coming from the NIDDK. Although useful metrics for some things, the PI-count and project-count are oversimplifications. It is important to note that the amount of support provided to each project varies widely. For instance, support of small molecule chemists at NIDDK and a number of projects involving biopolymer analysis at NIDDK (Dean, Bernstein, Shiloach) were very involved while most of the support provided to non-NIDDK labs involved one or two low staff time experiments. Support of Kenner Rice (NIDA) is a special case as he only recently moved to NIDA from NIDDK and has had a long-standing working relationship with the facility in all its historical forms. In addition to working in direct support of PI projects staff and resources are used to update methodology, adopting new and proven approaches of clear importance to the NIDDK PI community and in a limited number of cases developing new approaches when these are of immediate importance to on-going PI projects and otherwise consistent with the facilitys technical philosophies.

从历史上看，该设施每年都支持40个PI的订单，其中约有70个年度报告级项目，其中约有三分之二来自NIDDK。 尽管在某些方面有用的指标，但PI计数和项目计数是过分的。重要的是要注意，为每个项目提供的支持量差异很大。例如，NIDDK的小分子化学家的支持以及在NIDDK（Dean，Bernstein，Shiloach）涉及生物聚合物分析的许多项目非常参与，而向非NIDDK实验室提供的大多数支持涉及一个或两个低的员工时间实验。肯纳·赖斯（Kenner Rice）（NIDA）的支持是一个特殊情况，因为他最近才从NIDDK搬到NIDA，并且与该设施的所有历史形式都有长期的工作关系。 除了直接支持PI项目外，还使用资源来更新方法论，采用新的且经过验证的方法对NIDDK PI社区的重要性，并且在有限的情况下，在有限的情况下开发了新方法，这至关重要。 - PI项目，否则与设施的技术理念一致。