Physiological measures and perceptual consequences of noise-induced auditory synaptopathy in humans.

人类噪声引起的听觉突触病的生理测量和感知后果。

基本信息

批准号：
10132288
负责人：
MAGDALENA WOJTCZAK
金额：
$ 36.41万
依托单位：
UNIVERSITY OF MINNESOTA
依托单位国家：
美国
项目类别：
财政年份：
2017
资助国家：
美国
起止时间：
2017-04-01 至 2023-03-31
项目状态：
已结题

来源：
https://reporter.nih.gov/project-details/10132288
关键词：
Acoustic Nerve Acoustics Affect Age Anesthesia procedures Animals Auditory Auditory Perception Auditory Threshold Behavioral Binaural Case Study Characteristics Clinic Clinical Cochlea Communication Complex Contralateral Control Groups Cues Data Detection Development Diagnosis Diagnostic Disease Environment Exposure to Fiber Frequencies Gender Goals Growth Hearing Tests High-Frequency Hearing Loss Human Individual Inner Hair Cells Lead Life Location Loudness Masks Measures Medial Methods Mus Noise Noise Induced Tinnitus Performance Pharmacologic Substance Physiological Physiology Population Preparation Psychophysics Recording of previous events Reflex action Reporting Research Series Signal Transduction Speech Speech Perception Stimulus Structure Synapses Target Populations Temporary Threshold Shift Testing Time Tinnitus Validation Variant Work auditory reflex base clinically relevant cochlear synaptopathy ear muscle experience experimental group experimental study feasibility testing hearing impairment hearing range hidden hearing loss middle ear normal hearing otoacoustic emission relating to nervous system response sound speech in noise tool

项目摘要

Recent studies in animals have shown that noise exposure causing temporary shifts in auditory thresholds can lead to permanent and severe damage to the synaptic connections between the inner hair cells in the cochlea and the auditory nerve. If such “auditory synaptopathy” occurs in humans, it would not be detected by current standard audiometric tests, but could potentially explain why many people complain of excessive difficulty in understanding speech in noisy backgrounds, despite having clinically normal hearing. The goal of this project is to determine whether auditory synaptopathy occurs in humans and, if so, to develop clinically feasible tests to diagnose it along with research tools to study its perceptual consequences. The project identifies three populations who are considered to be potential suffers of auditory synaptopathy: 1) People who suffer from tinnitus following noise exposure, but who have clinically normal hearing (i.e., normal audiometric thresholds between 250 and 8000 Hz); 2) People who report having a history of exposure to loud sound, but have clinically normal hearing; 3) People with mild-to-moderate hearing loss at high frequencies (> 2 kHz) but clinically normal hearing at low frequencies. Results from these three groups will be compared with those from an age- and gender-matched control group of people with normal hearing and no reported tinnitus or excessive noise exposure. The project has a three-pronged approach, involving physiological, perceptual, and speech- based measures. The first aim studies the potential effects of synaptopathy on two auditory reflexes: the middle ear muscle reflex (MEMR) and the medial olivocochlear reflex (MOCR). Pilot data suggest that potential sufferers of auditory synaptopathy have severely reduced MEMR, in line with previous animal studies. The second aim investigates potential perceptual consequences of synaptopathy by measuring sensitivity to basic acoustic attributes, such as amplitude and frequency modulation, with and without background noise. Pilot data suggest that potential suffers of auditory synaptopathy are particularly susceptible to the effects of noise, even if their performance in quiet is normal. The third aim studies speech perception in a variety of background situations, including noise and speech interference with and without added reverberation. The experiments test the prediction that performance will be affected by synaptopathy particularly in cases where the level of the background noise is variable and unpredictable, and where the target and interfering speech are distinguishable only by small differences in fundamental frequency or spatial location. The results from the project will provide important new information and clinically relevant tests of a condition that potentially affects millions of people in the US and worldwide. Reliable indicators and diagnoses of auditory synaptopathy in humans will be crucial in the development of new pharmaceutical treatments of the disorder.

最近对动物的研究表明，噪音暴露会导致听觉阈值暂时变化导致耳蜗内毛细胞之间的突触连接永久性且严重受损如果这种“听觉突触病”发生在人类身上，电流就无法检测到。标准听力测试，但可能可以解释为什么许多人抱怨听力测试过于困难尽管听力在临床上正常，但仍能在嘈杂的背景下理解语音该项目的目标。确定人类是否发生听觉突触病，如果是，则开发临床上可行的测试诊断它以及研究其感知后果的研究工具该项目确定了三个。被认为可能患有听觉突触病的人群： 1) 患有听觉突触病的人噪声暴露后耳鸣，但临床听力正常（即正常听力阈值） 2) 自称曾接触过大声喧哗的人，但临床听力正常；3) 高频（> 2 kHz）有轻度至中度听力损失但将这三组的临床正常听力结果与来自其他组的结果进行比较。年龄和性别匹配的对照组，听力正常，没有耳鸣或过度耳鸣的报告该项目采用三管齐下的方法，涉及生理、感知和言语。第一个目标是研究突触病对两种听觉反射的潜在影响：中耳肌肉反射（MEMR）和内侧橄榄耳蜗反射（MOCR）的试验数据表明存在潜力。听觉突触病患者的 MEMR 严重降低，这与之前的动物研究结果一致。第二个目标是通过测量对基本信息的敏感性来研究突触病的潜在感知后果声学属性，例如幅度和频率调制，有或没有背景噪声。表明听觉突触病的潜在患者特别容易受到噪音的影响，即使第三个目标是研究各种背景下的言语感知。情况下，包括有或没有添加混响的噪声和语音干扰的实验测试。预测性能将受到突触病的影响，特别是在突触水平的情况下背景噪声是可变且不可预测的，目标语音和干扰语音在哪里仅可通过基频或空间位置的微小差异来区分。项目将提供重要的新信息以及对可能影响的病症的临床相关测试美国和全世界数百万人的听觉突触病的可靠指标和诊断。人类对于开发治疗这种疾病的新药物至关重要。