Peripheral and central contributions to auditory temporal processing deficits and speech understanding in older cochlear implantees

外周和中枢对老年人工耳蜗植入者听觉时间处理缺陷和言语理解的贡献

• 批准号: 10630111
• 负责人: Matthew J. Goupell
• 金额: $ 56.07万
• 依托单位: UNIV OF MARYLAND, COLLEGE PARK
• 依托单位国家: 美国
• 财政年份: 2022
• 资助国家: 美国
• 起止时间: 2022-04-01 至 2027-03-31
• 项目状态: 未结题
• 来源: https://reporter.nih.gov/project-details/10630111
• 关键词: Accounting; Acoustic Nerve; Acoustics; Action Potentials; Adult; Affect; Age; Aging; Auditory; Auditory area; Biological; Bionics; Brain Stem; Bypass; Cochlea; Cochlear Implants; Cognitive; Communication; Compensation; Complex; Cueing for speech; Effectiveness; Elderly; Electric Stimulation; Electrodes; Electrophysiology (science); Generations; Goals; Grant; Hearing; Individual; Intervention; Knowledge; Language; Link; Location; Measurement; Measures; Mission; National Institute on Deafness and Other Communication Disorders; Outcome; Perception; Performance; Peripheral; Play; Presbycusis; Public Health; Quality of life; Rehabilitation therapy; Research; Role; Scanning; Signal Transduction; Speech; Speech Perception; Stimulus; Technology; Testing; United States National Institutes of Health; X-Ray Computed Tomography; age effect; age related; aging auditory system; auditory processing; baby boomer; design; disability; effectiveness evaluation; electric impedance; experimental study; hearing impairment; hearing restoration; improved; innovation; neural; remediation; simulation; speech accuracy; young adult

This research aims to understand age-related temporal processing in older cochlear-implant (CI) users. The gap in knowledge is that critical measurements and comparisons have been unavailable to disentangle peripheral from central factors that impact CI performance. The long-term goals of this grant are to (1) understand the biological effects of auditory aging and (2) determine how to best remediate age-related auditory deficits with a CI. The overall objective of this application, which is the next step toward attainment of our long-term goals, is to disentangle the peripheral and central contributions to age-related temporal processing deficits in CI users. Our central hypothesis is that age-related speech perception deficits are explained by unique contributions from pe- ripheral and central auditory functions, which significantly affect outcomes in older CI users. The rationale is that CIs are uniquely suited to disentangle peripheral vs central contributions of age-related temporal processing deficits because they can bypass or easily characterize peripheral contributions to hearing, making an ideal system for auditory aging research. We plan to test our central hypothesis by pursuing the following specific aims: (1) Determine the extent to which temporal processing from single-electrode stimulation can be explained by aging and the peripheral electrode-to-neural interface in CI subjects; (2) Determine the extent to which speech perception can be explained by aging and the peripheral electrode-to-neural interface in CI subjects; (3) Deter- mine the extent and manner in which central auditory compensation overcomes peripheral processing deficits that contribute to age-related performance declines in CI subjects. These aims will yield the following expected outcomes. First, we will understand how aging and ENI correlate with each other, and how well peripheral con- tributions explain simple single-electrode temporal-processing performance. Second, we will understand if pe- ripheral contributions play a smaller role in explaining speech perception performance using multi-electrode stim- ulation, relative to perception of simple signals presented to single electrodes. Third, we will ascertain if age- related central processing deficits contribute above and beyond the peripheral deficits for processing of both simple and complex acoustic signals (including speech) among CI listeners. The proposed research is significant because expanding our understanding of the locus of the age-related temporal processing deficits will help de- velop age-specific guidance to CI candidacy, approaches to CI programming, and CI rehabilitation, improving an older CI user’s performance and quality of life. The proposed research is innovative because CIs offer a unique ability to bypass and characterize the periphery, allowing us to disentangle peripheral vs central mecha- nisms that contribute to age-related hearing deficits.

这项研究旨在了解老年人工耳蜗（CI）用户中与年龄相关的临时处理。差距 在Knowle中，关键的测量和比较对于脱离外围而言无法使用 来自影响CI性能的主要因素。这笔赠款的长期目标是（1）了解 听觉衰老的生物学效应和（2）确定如何最好地补救与年龄相关的听觉定义 CI。该应用程序的总体目标是实现我们长期目标的下一步，是 解开对CI用户中与年龄相关的临时处理防御的外围和中心贡献。我们的 中心假设是，与年龄相关的语音感知定义是由PE-的独特贡献解释的 Riperal和Central听觉功能，这显着影响了年长CI用户的结果。理由是 CI独特地适合于解开外围与年龄有关的临时处理的中心贡献 缺陷是因为它们可以绕过或轻松地表征听力的外围贡献，从而成为理想 听觉衰老研究系统。我们计划通过追求以下特定的特定假设来检验我们的中心假设 目的：（1）确定可以解释单电极刺激的临时处理程度 通过衰老和CI受试者的外围电极到神经界面； （2）确定演讲的程度 可以通过CI受试者的老化和外围电极到神经界面来解释感知。 （3）威胁 - 挖掘中央听觉补偿克服外围处理缺陷的程度和方式 这导致与年龄相关的CI受试者的表现下降。这些目标将产生以下预期 结果。首先，我们将了解衰老和ENI如何相互关联，外围的结合程度如何 贡献解释了简单的单电极临时处理性能。其次，我们将了解是否 成熟者的贡献在使用多电极刺激的解释语音感知表现方面起着较小的作用 ulation，相对于对单电极的简单信号感知的感知。第三，我们将确定年龄是否 相关的中央处理定义了贡献的贡献，超出了外围定义的处理 CI听众中简单而复杂的声学信号（包括语音）。拟议的研究很重要 因为扩展我们对与年龄相关的临时处理缺陷所在地的理解将有助于消除 CI候选资格，CI编程的方法和CI康复，改进 CI年龄较大的用户的表现和生活质量。拟议的研究具有创新性，因为CI提供了 绕过和表征外围的独特能力，使我们能够解散外围与中央机械 导致与年龄相关的听力缺陷的局势。

项目成果

Stimulus context affects the phonemic categorization of temporally based word contrasts in adult cochlear-implant users.

刺激环境会影响成年人工耳蜗使用者基于时间的单词对比的音位分类。

• DOI: 10.1121/10.0009838
• 发表时间: 2022
• 期刊: The Journal of the Acoustical Society of America
• 作者: Xie,Zilong;Anderson,Samira;Goupell,MatthewJ
• 通讯作者: Goupell,MatthewJ

Effect of Chronological Age on Pulse Rate Discrimination in Adult Cochlear-Implant Users.

• DOI: 10.1177/23312165211007367
• 发表时间: 2021-01
• 期刊: Trends in hearing
• 影响因子: 2.7
• 作者: Johnson KC;Xie Z;Shader MJ;Mayo PG;Goupell MJ
• 通讯作者: Goupell MJ

Accuracy and cue use in word segmentation for cochlear-implant listeners and normal-hearing listeners presented vocoded speech.

人工耳蜗听众和正常听力听众呈现声码语音的分词准确性和提示使用。

• DOI: 10.1121/10.0006448
• 发表时间: 2021
• 期刊: The Journal of the Acoustical Society of America
• 作者: Heffner,ChristopherC;Jaekel,BrittanyN;Newman,RochelleS;Goupell,MatthewJ
• 通讯作者: Goupell,MatthewJ

Letter to the Editor: Possible Sex Effects on the Processing of Temporal Cues in Word Segments in Adult Cochlear-Implant Users.

致编辑的信：性别对成年人工耳蜗用户处理词段中的时间线索可能产生的影响。

• DOI: 10.1177/2331216520946675
• 发表时间: 2020
• 期刊: Trends in hearing
• 影响因子: 2.7
• 作者: Xie,Zilong;Shader,MaureenJ;Gordon-Salant,Sandra;Anderson,Samira;Goupell,MatthewJ
• 通讯作者: Goupell,MatthewJ