Biostatistics and Data Management Core

生物统计和数据管理核心

• 批准号: 10084051
• 负责人: CONSTANTIN THEODORE YIANNOUTSOS
• 金额: $ 11.63万
• 依托单位: INDIANA UNIV-PURDUE UNIV AT INDIANAPOLIS
• 依托单位国家: 美国
• 财政年份: 2020
• 资助国家: 美国
• 起止时间: 2020-09-07 至 2025-08-31
• 项目状态: 未结题
• 来源: https://reporter.nih.gov/project-details/10084051
• 关键词: AIDS/HIV problem; Acquired Immunodeficiency Syndrome; Africa; Archives; Biometry; Cervical; Collaborations; Collection; Computer software; Country; Data; Data Analyses; Data Collection; Databases; Derivation procedure; Development; Ensure; Epidemiology; Exercise; Grant; Health; Human Papillomavirus; Human Resources; Informatics; Institutes; Institution; International; Lead; Leadership; Link; Malignant neoplasm of cervix uteri; Manuscripts; Mentorship; Methods; Pilot Projects; Privatization; Procedures; Reporting; Reproducibility; Research; Research Design; Research Personnel; Research Project Grants; Resource Sharing; Sample Size; Secure; Site; Statistical Data Interpretation; Training; Training Activity; Training and Education; Validation; Woman; Work; Writing; advanced analytics; analytical method; career development; data archive; data centers; data exchange; data literacy; data management; data quality; design; experience; experimental study; human subject protection; instrument; member; programs; research study; statistics; symposium; training opportunity; transmission process

Abstract: The Biostatistics and Data Management Core (BDMC) of the East Africa Consortium for HPV and Cervical Cancer (EACHC) is a shared resource for study design, research collaboration and the collection, management, sharing and analysis of all data generated from all constituent research projects in the Consortium. The BDMC will provide a space for research collaboration for all investigators, enable rigorous study design and offer expertise in the collection, validation, sharing and analysis of all data generated in each project. The BDMC will also facilitate the protection of human subjects by developing and deploying secure hardware and software solutions for storage and transmission of data containing private health information. In conjunction with the Developmental Core, we will offer opportunities for training and mentorship in data collection, management and analysis. The BDMC, which is embedded in the Regional Data Center of the East Africa Regional Consortium of the International Epidemiology Databases to Evaluate AIDS (IeDEA), will use its expertise with advanced analytical methods and management of data generated from multiple programs, hardware and software platforms and countries in the region to accomplish the following three inter-related Specific Aims: Specific Aim 1: Provide statistical leadership in study design, data analysis and presentation of results for all projects proposed by the Consortium. Specific Aim 2: Offer informatics and data management expertise in the collection, harmonization, validation, integration and overall management of data generated by all research projects proposed in this application. Specific Aim 3: Serve as focal point for mentorship and training in informatics, data management and analysis for all members of the Institute, build technical and research capacity in informatics and statistics and develop a culture of rigorous study design, experimentation and reproducible research. Through these efforts, the BDMC will enable a culture of openness, sharing and reproducible research by developing operating procedures for collection, management, secure storage of research data and archiving of data and analysis software and will contribute to capacity building in the region by providing training and education with respect to study design and data literacy

抽象的： 东非 HPV 和宫颈癌联盟的生物统计和数据管理核心 (BDMC) 癌症 (EACHC) 是一个用于研究设计、研究合作以及收集、管理、 共享和分析联盟所有组成研究项目产生的所有数据。 BDMC 将为所有研究人员提供研究合作的空间，实现严格的研究设计并提供 收集、验证、共享和分析每个项目中生成的所有数据的专业知识。 BDMC 将 还通过开发和部署安全的硬件和软件来促进对人类受试者的保护 用于存储和传输包含私人健康信息的数据的解决方案。结合 发展核心，我们将提供数据收集、管理和培训方面的培训和指导机会 分析。 BDMC，嵌入东非区域联盟的区域数据中心 评估艾滋病的国际流行病学数据库 (IeDEA) 将利用其专业知识和先进的分析能力 从多个程序、硬件和软件平台生成的数据的方法和管理以及 该地区国家要实现以下三个相互关联的具体目标： 具体目标 1：在研究设计、数据分析和结果呈现方面为所有人提供统计领导力 联合体提出的项目。 具体目标 2：提供收集、协调、验证、 整合和全面管理本申请中提出的所有研究项目生成的数据。 具体目标 3：充当信息学、数据管理和分析领域指导和培训的焦点 为研究所的所有成员建立信息学和统计方面的技术和研究能力，并制定 严格的研究设计、实验和可重复研究的文化。 通过这些努力，BDMC 将通过以下方式营造开放、共享和可重复研究的文化： 制定收集、管理、安全存储研究数据和归档的操作程序 数据和分析软件，并将通过提供培训和服务来促进该地区的能力建设 研究设计和数据素养方面的教育