East Africa IEDEA Regional Consortium

东非 IEDEA 区域联盟

基本信息

批准号：
7918579
负责人：
CONSTANTIN THEODORE YIANNOUTSOS
金额：
$ 78.43万
依托单位：
INDIANA UNIV-PURDUE UNIV AT INDIANAPOLIS
依托单位国家：
美国
项目类别：
财政年份：
2009
资助国家：
美国
起止时间：
2009-09-25 至 2011-08-31
项目状态：
已结题

来源：
https://reporter.nih.gov/project-details/7918579
关键词：
AIDS Treatment Research AIDS/HIV problem Accounting Address Adherence Africa Africa South of the Sahara African Anti-Retroviral Agents Area CD4 Positive T Lymphocytes California Caring Cell Count Cells Child Clinical Clinical Protocols Communicable Diseases Communities Complex Country Data Data Sources Databases Development Effectiveness Eligibility Determination Evaluation Failure Foundations Funding Future Guidelines HIV HIV-1 Highly Active Antiretroviral Therapy Immunologics Incidence Indiana Individual Infant formula Infection Intervention Kenya Life Malaria Malnutrition Medical Methods Mind Monitor Mortality Determinants Outcome Patients Persons Population Poverty Predictive Factor Principal Investigator Protocols documentation Public Health Research Research Personnel Research Project Grants Resistance Resources San Francisco Site Staging Symptoms Tanzania Time Training and Education Treatment Failure Treatment Protocols Tuberculosis Uganda Universities Woman World Health Organization antiretroviral therapy cohort cost data sharing design feeding follow-up infant outcome instrument meetings men pandemic disease pathogen patient population programs prospective response scale up simulation therapy development treatment duration treatment program trend waterborne

项目摘要

Forty million people around the world now live with HIV/AIDS, the majority in sub-Saharan Africa. In the East African countries of Kenya, Tanzania and Uganda alone, nearly seven million men, women and children are infected with HIV. Despite the fact that the developing world is the epicenter of the HIV/AIDS pandemic, most research initiatives and treatment guidelines have been developed using patient populations from resource-rich areas. While important clinical protocols and treatment guidelines have emerged from these research initiatives they may not successfully transfer to the vast majority of HIV/AIDS patients who live in resource-poor areas. As an example, while most clinical protocols have been developed among populations infected with HIV-1 subtype B, the predominant strain in the developed world, in sub-Saharan Africa, in general, and East Africa, in particular, a variety of HIV-1 non-B subtypes are found. This fact may have far- reaching implications for critical aspects of antiretroviral treatment, including the timing of initiation of antiretroviral therapy and development of resistance to first-line regimens. Also, due to poverty, malnutrition and the existence of various infectious diseases not commonly encountered in more resource-rich parts of the world, such as malaria, tuberculosis, and waterborne pathogens, treatment and care of HIV-infected patients in sub-Saharan Africa is uniquely complex as compared to more prosperous regions of the globe. Indiana University, with partners at the University of California San Francisco, Columbia University, Yale University, Moi University in Kenya and Mbarara University in Uganda and support from the World Health Organization and various agencies and private foundations, have established a number of extensive HIV/AIDS treatment and research networks in the East African nations of Kenya, Uganda, and Tanzania. With this application we aim to create a regional Data Center for East Africa as part of the IEDEA Consortium. This Center will not only merge and share data among current and future partners, but also offer unparalleled research capacity to identify and address questions that are amendable to combined regional database analysis. Our East Africa Regional IEDEA Consortium will fulfill the following functions: 1) Identify data from existing HIV/AIDS care and research networks in the East Africa region; 2) Develop protocols to harmonize and merge data and provide training and education to accomplish this task; 3) Share data within the East Africa Regional Consortium, the worldwide IEDEA Consortium, and collaborating investigators from the broader scientific community; 4) Identify and pursue critical questions related to HIV/AIDS care, treatment and research that can be addressed with combined regional data. Particular emphasis will be placed on HIV-related questions that have broad applicability across regions and populations.

目前全世界有四千万人感染艾滋病毒/艾滋病，其中大多数生活在撒哈拉以南非洲地区。在东方仅肯尼亚、坦桑尼亚和乌干达等非洲国家就有近七百万男人、女人和儿童感染艾滋病毒。尽管发展中国家是艾滋病毒/艾滋病流行的中心，大多数研究举措和治疗指南都是根据来自以下国家的患者群体制定的：资源丰富的地区。虽然重要的临床方案和治疗指南已经从中产生他们可能无法成功地将研究举措转移到居住在美国的绝大多数艾滋病毒/艾滋病患者身上资源贫乏地区。例如，虽然大多数临床方案是在人群中制定的感染了 HIV-1 B 亚型，这是发达国家、撒哈拉以南非洲、一般而言，特别是东非，发现了多种HIV-1非B亚型。这一事实可能具有深远的意义—— 对抗逆转录病毒治疗的关键方面产生影响，包括开始治疗的时间抗逆转录病毒治疗和对一线治疗方案产生耐药性。另外，由于贫穷、营养不良以及资源丰富地区不常见的各种传染病的存在世界各地，如疟疾、结核病和水传播病原体、艾滋病毒感染者的治疗和护理与全球更繁荣的地区相比，撒哈拉以南非洲地区的患者情况尤为复杂。印第安纳大学与加州大学旧金山分校、哥伦比亚大学合作，耶鲁大学、肯尼亚莫伊大学和乌干达姆巴拉拉大学以及来自世界卫生组织以及各个机构和私人基金会，已经建立了一些东非国家肯尼亚广泛的艾滋病毒/艾滋病治疗和研究网络，乌干达、坦桑尼亚。通过此应用程序，我们的目标是为东非创建一个区域数据中心作为 IEDEA 联盟的一部分。该中心不仅将合并和共享当前和未来的合作伙伴，而且还提供无与伦比的研究能力来识别和解决以下问题：可修改为结合区域数据库分析。我们的东非地区 IEDEA 联盟将履行以下职能： 1) 确定东部现有艾滋病毒/艾滋病护理和研究网络的数据非洲地区； 2) 制定协调和合并数据的协议，并为以下人员提供培训和教育完成这个任务； 3) 在东非区域联盟（全球 IEDEA）内共享数据联盟以及来自更广泛科学界的合作研究人员； 4）识别并追求与艾滋病毒/艾滋病护理、治疗和研究有关的关键问题可以通过联合解决区域数据。将特别强调具有广泛适用性的与艾滋病毒相关的问题跨地区和人群。