East Africa IEDEA Regional Consortium

东非 IEDEA 区域联盟

• 批准号: 7918580
• 负责人: CONSTANTIN THEODORE YIANNOUTSOS
• 金额: $ 88.24万
• 依托单位: INDIANA UNIV-PURDUE UNIV AT INDIANAPOLIS
• 依托单位国家: 美国
• 财政年份: 2009
• 资助国家: 美国
• 起止时间: 2009-09-17 至 2011-08-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/7918580
• 关键词: AIDS Treatment Research; AIDS/HIV problem; Accounting; Address; Adherence; Africa; Africa South of the Sahara; African; Anti-Retroviral Agents; Area; CD4 Positive T Lymphocytes; California; Caring; Cell Count; Cells; Child; Clinical; Clinical Protocols; Communicable Diseases; Communities; Complex; Country; Data; Data Sources; Databases; Development; Effectiveness; Eligibility Determination; Evaluation; Failure; Foundations; Funding; Future; Guidelines; HIV; HIV-1; Highly Active Antiretroviral Therapy; Immunologics; Incidence; Indiana; Individual; Infant formula; Infection; Intervention; Kenya; Life; Malaria; Malnutrition; Medical; Methods; Mind; Monitor; Mortality Determinants; Outcome; Patients; Persons; Population; Poverty; Predictive Factor; Principal Investigator; Protocols documentation; Public Health; Research; Research Personnel; Research Project Grants; Resistance; Resources; San Francisco; Site; Staging; Symptoms; Tanzania; Time; Training and Education; Treatment Failure; Treatment Protocols; Tuberculosis; Uganda; Universities; Woman; World Health Organization; antiretroviral therapy; cohort; cost; data sharing; design; feeding; follow-up; infant outcome; instrument; meetings; men; pandemic disease; pathogen; patient population; programs; prospective; response; scale up; simulation; therapy development; treatment duration; treatment program; trend; waterborne

Forty million people around the world now live with HIV/AIDS, the majority in sub-Saharan Africa. In the East African countries of Kenya, Tanzania and Uganda alone, nearly seven million men, women and children are infected with HIV. Despite the fact that the developing world is the epicenter of the HIV/AIDS pandemic, most research initiatives and treatment guidelines have been developed using patient populations from resource-rich areas. While important clinical protocols and treatment guidelines have emerged from these research initiatives they may not successfully transfer to the vast majority of HIV/AIDS patients who live in resource-poor areas. As an example, while most clinical protocols have been developed among populations infected with HIV-1 subtype B, the predominant strain in the developed world, in sub-Saharan Africa, in general, and East Africa, in particular, a variety of HIV-1 non-B subtypes are found. This fact may have far- reaching implications for critical aspects of antiretroviral treatment, including the timing of initiation of antiretroviral therapy and development of resistance to first-line regimens. Also, due to poverty, malnutrition and the existence of various infectious diseases not commonly encountered in more resource-rich parts of the world, such as malaria, tuberculosis, and waterborne pathogens, treatment and care of HIV-infected patients in sub-Saharan Africa is uniquely complex as compared to more prosperous regions of the globe. Indiana University, with partners at the University of California San Francisco, Columbia University, Yale University, Moi University in Kenya and Mbarara University in Uganda and support from the World Health Organization and various agencies and private foundations, have established a number of extensive HIV/AIDS treatment and research networks in the East African nations of Kenya, Uganda, and Tanzania. With this application we aim to create a regional Data Center for East Africa as part of the IEDEA Consortium. This Center will not only merge and share data among current and future partners, but also offer unparalleled research capacity to identify and address questions that are amendable to combined regional database analysis. Our East Africa Regional IEDEA Consortium will fulfill the following functions: 1) Identify data from existing HIV/AIDS care and research networks in the East Africa region; 2) Develop protocols to harmonize and merge data and provide training and education to accomplish this task; 3) Share data within the East Africa Regional Consortium, the worldwide IEDEA Consortium, and collaborating investigators from the broader scientific community; 4) Identify and pursue critical questions related to HIV/AIDS care, treatment and research that can be addressed with combined regional data. Particular emphasis will be placed on HIV-related questions that have broad applicability across regions and populations.

现在，世界各地有400万人生活在撒哈拉以南非洲的大多数艾滋病毒/艾滋病。在东方 肯尼亚，坦桑尼亚和乌干达的非洲国家，近700万男人，妇女和儿童是 感染艾滋病毒。尽管发展中国家是艾滋病毒/艾滋病大流行的中心，但 大多数研究计划和治疗指南都是使用来自 资源丰富的地区。虽然重要的临床方案和治疗指南已经出现 研究举措他们可能不会成功转移到居住在的绝大多数艾滋病毒/艾滋病患者中 资源贫乏的地区。例如，虽然大多数临床方案已在人群中开发 感染了撒哈拉以南非洲的发达国家HIV-1亚型B， 通常发现了一般和东非，尤其是发现了各种HIV-1非B亚型。这个事实可能有很多 对抗逆转录病毒治疗的关键方面产生影响，包括开始的时间 抗逆转录病毒疗法和对一线方案的抵抗力的发展。另外，由于贫穷，营养不良 以及在更多资源丰富的部分中通常遇到的各种传染病的存在 世界，例如疟疾，结核病和水传播病原体，艾滋病毒感染的治疗和护理 与全球更繁荣的地区相比，撒哈拉以南非洲的患者非常复杂。 印第安纳大学，与加利福尼亚大学旧金山大学哥伦比亚大学的合作伙伴， 耶鲁大学，肯尼亚的MOI大学和乌干达的姆巴拉拉大学，并得到 世界卫生组织以及各个机构和私人基金会已经建立了一个 肯尼亚东非国家广泛的艾滋病毒/艾滋病治疗和研究网络 乌干达和坦桑尼亚。通过此应用程序，我们旨在为东非创建一个区域数据中心 作为IEDEA财团的一部分。该中心不仅将合并并共享当前和 未来的合作伙伴，但也提供无与伦比的研究能力来识别和解决问题 可以对结合区域数据库分析进行评估。我们的东非地区IEDEA财团将 履行以下功能：1）从东方现有的艾滋病毒/艾滋病护理和研究网络中确定数据 非洲地区； 2）制定协议和合并数据的协议，并提供培训和教育 完成这项任务； 3）在全球IEDEA中共享东非地区财团内的数据 财团，以及来自更广泛的科学界的调查人员； 4）识别和追求 与艾滋病毒/艾滋病护理，治疗和研究有关的关键问题，可以合并解决 区域数据。特别重点将放在具有广泛适用性的与HIV相关的问题上 跨地区和人口。